Medically reviewed on October 2, 2017
What is hydrochlorothiazide and lisinopril?
Hydrochlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention.
Lisinopril is in an ACE inhibitor. ACE stands for angiotensin converting enzyme. Lisinopril lowers blood pressure and also relieves symptoms of fluid retention.
Hydrochlorothiazide and lisinopril is a combination medicine used to treat hypertension (high blood pressure).
Hydrochlorothiazide and lisinopril may also be used for purposes not listed in this medication guide.
Do not use if you are pregnant. If you become pregnant, stop taking hydrochlorothiazide and lisinopril and tell your doctor right away.
You should not use this medicine if you have ever had angioedema, if you are unable to urinate, or if you are allergic to sulfa drugs or to any ACE inhibitor. Do not take hydrochlorothiazide and lisinopril within 36 hours before or after taking medicine that contains sacubatril (such as Entresto).
Before taking this medicine
You should not use this medicine if you are allergic to hydrochlorothiazide or lisinopril, or if:
you have hereditary angioedema;
you are unable to urinate;
you recently took a heart medicine called sacubatril;
you have an allergy to sulfa drugs; or
Do not take hydrochlorothiazide and lisinopril within 36 hours before or after taking medicine that contains sacubatril (such as Entresto).
If you have diabetes, do not use hydrochlorothiazide and lisinopril together with any medication that contains aliskiren (such as Tekturna or Tekamlo).
You may also need to avoid taking hydrochlorothiazide and lisinopril with aliskiren if you have kidney disease.
To make sure hydrochlorothiazide and lisinopril is safe for you, tell your doctor if you have:
kidney disease (or if you are on dialysis);
heart disease or congestive heart failure;
an allergy to sulfa drugs or penicillin.
Do not use if you are pregnant. If you become pregnant, stop taking this medicine and tell your doctor right away. Lisinopril can cause injury or death to the unborn baby if you take the medicine during your second or third trimester.
This medicine can pass into breast milk and may harm a nursing baby. Tell your doctor if you are breast-feeding a baby.
How should I take hydrochlorothiazide and lisinopril?
Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not take hydrochlorothiazide and lisinopril in larger or smaller amounts or for longer than recommended.
Take each dose with a full glass of water.
Call your doctor if you have ongoing vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while taking this medicine. This can lead to very low blood pressure, electrolyte disorders, or kidney failure.
While using hydrochlorothiazide and lisinopril, you may need frequent blood tests at your doctor's office. Your blood pressure will need to be checked often.
Keep using this medicine as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.
If you need surgery or medical tests, tell the doctor ahead of time that you are taking medicine that contains hydrochlorothiazide.
Store at room temperature away from moisture, heat, and light.
What happens if I miss a dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while taking hydrochlorothiazide and lisinopril?
Drinking alcohol can further lower your blood pressure and may increase certain side effects of hydrochlorothiazide and lisinopril.
Do not use potassium supplements or salt substitutes while you are taking this medicine, unless your doctor has told you to.
Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.
Avoid becoming overheated or dehydrated during exercise, in hot weather, or by not drinking enough fluids. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.
Hydrochlorothiazide and lisinopril side effects
Get emergency medical help if you have signs of an allergic reaction: hives; severe stomach pain; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
a light-headed feeling, like you might pass out;
eye pain, vision problems;
little or no urination;
weakness, drowsiness, or feeling restless;
fever, chills, sore throat, mouth sores, trouble swallowing;
jaundice (yellowing of the skin or eyes);
high potassium--nausea, tingly feeling, chest pain, irregular heartbeats, loss of movement;
low levels of sodium in the body--headache, confusion, slurred speech, severe weakness, vomiting, loss of coordination, feeling unsteady.
Common side effects may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
Hydrochlorothiazide and lisinopril dosing information
Usual Adult Dose for Hypertension:
Initial dose: Hydrochlorothiazide 12.5 mg-Lisinopril 10 to 20 mg orally once a day, depending on the current monotherapy dose
Maximum dose: Hydrochlorothiazide 50 mg-Lisinopril 80 mg per day
-May increase dose every 2 to 3 weeks.
-If blood pressure is controlled with monotherapy hydrochlorothiazide 25 mg per day, but significant potassium loss occurs, then similar or greater blood pressure control without electrolyte disturbance may be achieved with hydrochlorothiazide 12.5 mg-lisinopril 10 mg orally once a day.
What other drugs will affect hydrochlorothiazide and lisinopril?
Other drugs may interact with hydrochlorothiazide and lisinopril, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Copyright 1996-2018 Cerner Multum, Inc. Version: 14.02.
More about hydrochlorothiazide/lisinopril
- Hydrochlorothiazide/lisinopril Side Effects
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- Drug class: ACE inhibitors with thiazides