Generic Name: hydrochlorothiazide and lisinopril (HYE droe KLOR oh THYE a zide and lye SIN oh pril)
Brand Names: Zestoretic
What is Zestoretic?
Zestoretic contains a combination of hydrochlorothiazide and lisinopril. Hydrochlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention.
Lisinopril is in an ACE inhibitor. ACE stands for angiotensin converting enzyme. Lisinopril lowers blood pressure and also relieves symptoms of fluid retention.
Zestoretic is used to treat hypertension (high blood pressure).
Zestoretic may also be used for purposes not listed in this medication guide.
Do not Zestoretic use if you are pregnant. If you become pregnant, stop taking this medicine and tell your doctor right away.
You should not use Zestoretic if you have hereditary angioedema, if you are unable to urinate, if you are allergic to sulfa drugs, or if you have ever had a severe allergic reaction to any ACE inhibitor.
If you have diabetes, do not use Zestoretic together with any medication that contains aliskiren (Amturnide, Tekturna, Tekamlo).
Before taking this medicine
You should not use Zestoretic if you are allergic to hydrochlorothiazide or lisinopril, or if:
you have hereditary angioedema;
you are unable to urinate;
you have an allergy to sulfa drugs; or
you have ever had a severe allergic reaction to any ACE inhibitor (benazepril, captopril, enalapril, fosinopril, moexipril, perindopril, quinapril, ramipril, trandolapril).
You may also need to avoid taking Zestoretic with aliskiren if you have kidney disease.
To make sure Zestoretic is safe for you, tell your doctor if you have:
kidney disease (or if you are on dialysis);
cirrhosis or other liver disease;
heart disease or congestive heart failure;
asthma or allergies;
an allergy to sulfa drugs or penicillin.
Do not use Zestoretic if you are pregnant. If you become pregnant, stop taking this medicine and tell your doctor right away. Lisinopril can cause injury or death to the unborn baby if you take the medicine during your second or third trimester.
Hydrochlorothiazide and lisinopril can pass into breast milk and may harm a nursing baby. Tell your doctor if you are breast-feeding a baby.
How should I take Zestoretic?
Take Zestoretic exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not take this medicine in larger or smaller amounts or for longer than recommended.
Take each dose with a full glass of water.
Call your doctor if you have ongoing vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while taking this medicine. This can lead to very low blood pressure, electrolyte disorders, or kidney failure.
While using Zestoretic, you may need frequent blood tests at your doctor's office. Your blood pressure will need to be checked often.
Keep using Zestoretic as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.
If you need surgery or medical tests, tell the doctor ahead of time that you are taking medicine that contains hydrochlorothiazide. You may need to stop using the medicine for a short time.
Store at room temperature away from moisture, heat, and light.
Zestoretic dosing information
Usual Adult Dose for Hypertension:
Initial dose: Hydrochlorothiazide 12.5 mg-Lisinopril 10 to 20 mg orally once a day, depending on the current monotherapy dose
Maximum dose: Hydrochlorothiazide 50 mg-Lisinopril 80 mg per day
-May increase dose every 2 to 3 weeks.
-If blood pressure is controlled with monotherapy hydrochlorothiazide 25 mg per day, but significant potassium loss occurs, then similar or greater blood pressure control without electrolyte disturbance may be achieved with hydrochlorothiazide 12.5 mg-lisinopril 10 mg orally once a day.
See also: Dosage Information (in more detail)
What happens if I miss a dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while taking Zestoretic?
Drinking alcohol can further lower your blood pressure and may increase certain side effects of this medicine.
Do not use potassium supplements or salt substitutes while you are taking Zestoretic, unless your doctor has told you to.
Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.
Avoid becoming overheated or dehydrated during exercise, in hot weather, or by not drinking enough fluids. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.
Zestoretic side effects
Get emergency medical help if you have signs of an allergic reaction to Zestoretic: hives; severe stomach pain; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
a light-headed feeling, like you might pass out;
eye pain, vision problems;
little or no urination;
weakness, drowsiness, or feeling restless;
fever, chills, sore throat, mouth sores, trouble swallowing;
jaundice (yellowing of the skin or eyes);
high potassium - nausea, slow or unusual heart rate, weakness, loss of movement;
low potassium - leg cramps, constipation, irregular heartbeats, fluttering in your chest, extreme thirst, increased urination, numbness or tingling, muscle weakness or limp feeling; or
low levels of sodium in the body - headache, confusion, slurred speech, severe weakness, vomiting, loss of coordination, feeling unsteady.
Common Zestoretic side effects may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
What other drugs will affect Zestoretic?
Other drugs may interact with hydrochlorothiazide and lisinopril, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.
More about Zestoretic (hydrochlorothiazide / lisinopril)
- Side Effects
- During Pregnancy
- Dosage Information
- Drug Images
- Drug Interactions
- Support Group
- Pricing & Coupons
- En Español
- 5 Reviews – Add your own review/rating
- Generic Availability
- Drug class: ACE inhibitors with thiazides
Other brands: Prinzide
Related treatment guides
Where can I get more information?
- Your pharmacist can provide more information about Zestoretic.
- Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Zestoretic only for the indication prescribed.
- Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2017 Cerner Multum, Inc. Version: 14.01.
Date modified: April 03, 2017
Last reviewed: March 08, 2017