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Hydrochlorothiazide / Lisinopril Dosage

Medically reviewed by Last updated on Jan 22, 2024.

Applies to the following strengths: 12.5 mg-20 mg; 25 mg-20 mg; 12.5 mg-10 mg

Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Hypertension

Initial dose: Hydrochlorothiazide 12.5 mg-Lisinopril 10 to 20 mg orally once a day, depending on the current monotherapy dose

Maximum dose: Hydrochlorothiazide 50 mg-Lisinopril 80 mg per day


Renal Dose Adjustments

Mild to moderate renal dysfunction (CrCl greater than 30 mL/min): No adjustment recommended.
Severe renal dysfunction (CrCl less than 30 mL/min): Not recommended; loop diuretics preferred over thiazides

Liver Dose Adjustments

Caution recommended



Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.


Data not available

Other Comments


Patient advice:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.