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Hydrochlorothiazide / lisinopril Side Effects

Medically reviewed by Last updated on Jun 30, 2023.

Applies to hydrochlorothiazide / lisinopril: oral tablet.


Oral route (Tablet)

Discontinue lisinopril/hydrochlorothiazide as soon as possible when pregnancy is detected, as drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus.

Serious side effects

Along with its needed effects, hydrochlorothiazide / lisinopril may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking hydrochlorothiazide / lisinopril:

Less common

Incidence not known

Other side effects

Some side effects of hydrochlorothiazide / lisinopril may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

For Healthcare Professionals

Applies to hydrochlorothiazide / lisinopril: oral tablet.


The most common adverse reactions were dizziness, headache, cough, fatigue, and orthostatic effects.[Ref]

Nervous system

Common (1% to 10%): Dizziness, headache, paresthesia

Uncommon (0.1% to 1%): Syncope

Frequency not reported: Vertigo, somnolence, tinnitus


Frequency not reported: Paresthesia, lightheadedness, vertigo


Common (1% to 10%): Dizziness, headache, syncope

Uncommon (0.1% to 1%): Paresthesia, vertigo, taste disturbance

Rare (less than 0.1%): Olfactory disturbance

Frequency not reported: Transient ischemic attacks, ataxia, memory impairment, tremor, stroke, peripheral neuropathy, hypersomnia[Ref]


Common (1% to 10%): Cough, upper respiratory tract infection

Frequency not reported: Common cold, nasal congestion, bronchitis, pharyngeal pain, dyspnea, pulmonary congestion, chronic sinusitis, allergic rhinitis, pharyngeal discomfort


Frequency not reported: Respiratory distress, pneumonitis, pulmonary edema


Common (1% to 10%): Cough

Uncommon (0.1% to 1%): Rhinitis

Very rare (less than 0.01%): Bronchospasm, sinusitis, allergic alveolitis/eosinophilic pneumonitis

Frequency not reported: Pulmonary embolism, pulmonary infarction, paroxysmal nocturnal dyspnea, malignant lung neoplasms, hemoptysis, pulmonary edema, pulmonary infiltrates, asthma, pleural effusion, pneumonia, wheezing, orthopnea, painful respiration, epistaxis, laryngitis, pharyngitis, rhinorrhea[Ref]


Common (1% to 10%): Fatigue, asthenia

Frequency not reported: Chest pain, chest discomfort, fever, trauma, otalgia


Frequency not reported: Fever, weakness, cramping


Uncommon (0.1% to 1%): Asthenia, fatigue

Frequency not reported: Malaise, edema, facial edema, pain, chills, peripheral edema, chest sound abnormal, breast pain[Ref]


Common (1% to 10%): Orthostatic effects, hypotension

Frequency not reported: Palpitation, flushing


Frequency not reported: Postural hypotension, necrotizing angiitis, vasculitis


Common (1% to 10%): Orthostatic effects

Uncommon (0.1% to 1%): Myocardial infarction or cerebrovascular accident, palpitation, tachycardia, Raynaud's syndrome

Frequency not reported: Flushing, cardiac arrest, worsening heart failure, arrhythmias, angina pectoris, decreased blood pressure, vasculitis[Ref]


Common (1% to 10%): Diarrhea, nausea, vomiting, dyspepsia

Frequency not reported: Abdominal pain, gastrointestinal cramps, dry mouth, constipation, heartburn, intestinal angioedema


Frequency not reported: Sialadenitis, gastric irritation, diarrhea, constipation, pancreatitis


Common (1% to 10%): Diarrhea, vomiting

Uncommon (0.1% to 1%): Nausea, abdominal pain, indigestion

Rare (0.01% to 0.1%): Dry mouth

Very rare (less than 0.01%): Pancreatitis, intestinal angioedema

Frequency not reported: Gastritis, flatulence, salivation increased[Ref]


Common (1% to 10%): Muscle cramps

Frequency not reported: Back pain, shoulder pain, knee pain, back strain, myalgia, foot pain


Frequency not reported: Systemic lupus erythematosus, muscle spasm, muscle weakness


Frequency not reported: Pelvic pain, flank pain, arthritis, arthralgia, neck pain, hip pain, joint pain, leg pain, arm pain, lumbago[Ref]


Common (1% to 10%): Impotence

Frequency not reported: Urinary tract infection


Frequency not reported: Glycosuria


Uncommon (0.1% to 1%): Impotence

Frequency not reported: Dysuria[Ref]


Frequency not reported: Pruritus, skin inflammation, diaphoresis, cutaneous pseudolymphoma, angioedema


Frequency not reported: Cutaneous vasculitis, photosensitivity reactions, rash, cutaneous lupus erythematosus-like reactions, reactivation of cutaneous lupus erythematosus, urticaria, toxic epidermal necrolysis, erythema multiforme, Stevens-Johnson syndrome, exfoliative dermatitis, alopecia, purpura


Uncommon (0.1% to 1%): Rash, pruritus

Rare (0.01% to 0.1%): Angioedema, urticaria, alopecia, psoriasis

Very rare (less than 0.01%): Diaphoresis, pemphigus, toxic epidermal necrolysis, Stevens-Johnson syndrome, erythema multiforme, cutaneous pseudolymphoma

Frequency not reported: Photosensitivity, skin lesions, skin infections[Ref]


Frequency not reported: Xanthopsia, transient blurred vision, acute myopia, acute angle-closure glaucoma


Frequency not reported: Xanthopsia


Frequency not reported: Visual loss, diplopia, photophobia[Ref]


Frequency not reported: Hemoglobin decreased, hematocrit decreased, anemia


Frequency not reported: Leukopenia, neutropenia/agranulocytosis, thrombocytopenia, aplastic anemia, hemolytic anemia, bone marrow depression


Rare (0.01% to 0.1%): Hemoglobin decreased, hematocrit decreased

Very rare (less than 0.01%): Bone marrow depression, anemia, thrombocytopenia, leukopenia, neutropenia, agranulocytosis, hemolytic anemia, lymphadenopathy[Ref]


Frequency not reported: BUN increased, serum creatinine increased


Frequency not reported: Renal dysfunction, interstitial nephritis, renal failure


Common (1% to 10%): Renal dysfunction

Uncommon (0.1% to 1%): Blood urea increased, serum creatinine increased

Rare (0.01% to 0.1%): Uremia, acute renal failure

Very rare (less than 0.01%): Oliguria/anuria

Frequency not reported: Progressive azotemia, pyelonephritis[Ref]


Frequency not reported: Libido decreased, depression


Frequency not reported: Restlessness, depression, sleep disturbance


Uncommon (0.1% to 1%): Sleep disturbance, mood alteration, depressive symptoms

Rare (less than 0.1%): Mental confusion

Frequency not reported: Hallucination, insomnia, nervousness, irritability[Ref]


Frequency not reported: Liver enzymes elevated, bilirubin elevated


Frequency not reported: Intrahepatic cholestatic jaundice


Uncommon (0.1% to 1%): Liver enzymes elevated, bilirubin elevated

Very rare (less than 0.01%): Hepatitis, jaundice, hepatic failure[Ref]


Frequency not reported: Viral infection, influenza


Frequency not reported: Anaphylactic reactions


Very rare (less than 0.01%): Autoimmune disease

Frequency not reported: Anaphylactoid reactions, herpes zoster[Ref]



Frequency not reported: Anorexia, hyperglycemia, hyperuricemia, hyponatremia, hypokalemia, hypochloremic alkalosis, hypomagnesemia, cholesterol increased, triglycerides increased, gout, appetite lost


Uncommon (0.1% to 1%): Hyperkalemia

Rare (0.01% to 0.1%): Hyponatremia

Very rare (less than 0.01%): Hypoglycemia

Frequency not reported: Anorexia, gout, weight loss, dehydration, fluid overload, weight gain[Ref]



Rare (less than 0.1%): Syndrome of inappropriate antidiuretic hormone secretion, gynecomastia

Frequency not reported: Diabetes mellitus[Ref]


1. Product Information. Prinzide (hydrochlorothiazide-lisinopril). Merck & Co., Inc. 2022.

2. Cerner Multum, Inc. UK Summary of Product Characteristics.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.