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Simponi User Reviews & Ratings (Page 4)

Simponi has an average rating of 6.4 out of 10 from a total of 118 reviews on Drugs.com. 55% of reviewers reported a positive experience, while 28% reported a negative experience.

Reviews for Simponi

Commonly mentioned side effects
  • Bar...
  • February 9, 2023

For Psoriatic Arthritis "I have been taking Osimponi since November 2022 for psoriatic arthritis spondylitis. I have been experiencing chronic fatigue, shortness of breath, infections, low hemoglobin, dizzy spells, and high cholesterol. It has also made me sick every day to the point I can hardly eat due to chronic nausea. Will not be taking next month's injection. Horrendous experience."

1 / 10
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  • Hii...
  • December 11, 2016

For Ankylosing Spondylitis "Had 1st shot of Simponi and didn't notice any change. I was also taking 2 pills of methotrexate. Doc upped methotrexate to 6 pills. I had been getting muscle spasms intermittently since starting Simponi. After 3rd shot, I got the muscle spasms the next day, and they lasted for a week. Doc took me off Simponi due to the muscle spasms and also because I didn't notice any change in AS."

1 / 10
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  • Man...
  • Taken for 1 to 6 months
  • September 30, 2019

For Ankylosing Spondylitis "I've been diagnosed with AS since 2010, but symptoms started in 2008. Started Simponi last month and was on my second shot last week. The first shot had been great, but after the second shot, I am experiencing constant dizziness."

6 / 10
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8 Report

Frequently asked questions

  • tc3...
  • Taken for 1 to 2 years
  • June 24, 2016

For Ankylosing Spondylitis "I'm a 48-year-old female that started showing symptoms at age 17, diagnosed at 19 with the HLA-B27 marker. Total hip replacement at 29, chronic chest pain due to fusing. I have tried a butt-load of meds over the years, most oral due to lack of insurance (which thankfully, I now have), which cost me renal failure stage 2, including Methotrexate. I have a Medtronic pain pump and am on Oxycodone currently too. I have tried Enbrel, Humira, and now Simponi. Simponi works very well for me WHEN I can get the smart injections to work."

9 / 10
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  • Ner...
  • Taken for 1 to 6 months
  • November 22, 2022

For Ankylosing Spondylitis "I was only on Simponi for 8 weeks, and sadly, it helped the pain and stiffness for my AS, but it caused major GI issues. I have IBD, and it is supposed to help with that, but it made mine 1000 times worse. Liquid diarrhea up to 10 times a day and abdominal pain were horrible. Once the meds wear off, the symptoms get better."

5 / 10
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4 Report

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  • gmo...
  • Taken for 1 to 6 months
  • July 30, 2015

For Spondyloarthritis "Been on this for 2 and a half months. After the second injection, I went 13 days without taking any Norco or Soma, whereas I typically took one a day and two a day, respectively. It took a bit to get my insurance to cover it, but I had a severe reaction to Humira, allowing me to. Amazingly, it seems to work even better than my Enbrel at 11 weeks."

9 / 10
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  • Boo...
  • Taken for 1 to 6 months
  • September 20, 2019

For Ulcerative Colitis "I have UC, fibromyalgia, RA, diabetes type 2, and many more health issues. I've been on SIMPONI for about 4 months, my symptoms have become worse: chronic pain, intense swelling, burning, tingling hands and feet, bloated stomach that just won't deflate, loss of appetite. I don't want to have the SIMPONI anymore. I'm now worried and scared, as it's rejected my body. I have just about had enough of the intense pain... I'm happy to hear good results from people it has worked for..."

1 / 10
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  • Vol...
  • Taken for 1 to 2 years
  • May 27, 2020

For Ulcerative Colitis "I've got UC, started therapy with Simponi almost two years ago because I was steroid-dependent, even if I generally felt well. The last colonoscopy, done 6 months ago, showed that I was in complete remission, and luckily, I still feel great. I haven't noticed any collateral effect, maybe I've just gained some weight, but probably I was underweight before (I am 1.63m tall, and my actual weight is 51.5kg)."

10 / 10
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  • non...
  • Taken for 1 to 6 months
  • January 16, 2022

For Psoriatic Arthritis "I tried the injection once before after coming off of another biologic that made my symptoms worse. I did not really give it a chance as I did not seem to get any better. I was frustrated with my symptoms and took myself off of everything for 3 months. I had terrible joint pain, could not open anything up, and severe rash flare-up, so I tried it again with better results. So far, I will be on my second consecutive dose shortly. The only thing I have found odd and maybe unrelated is heart flutters and an upset stomach."

4 / 10
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  • ian...
  • Taken for 5 to 10 years
  • November 23, 2023

For Psoriatic Arthritis "This medication has been a life changer. After years of medications that seemed to have no major effect on my condition, there was a very noticeable improvement in my affected joints from the very first dose. I have suffered no side effects and have found both types of injections easier to administer than I imagined."

10 / 10
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  • Ani...
  • Taken for 1 to 6 months
  • July 1, 2022

For Ankylosing Spondylitis "Used for psoriatic arthritis and ankylosing spondylitis. Seriously multiplied my pain by at least 10, psoriasis was also much, much worse than I’d ever had it previously. Extremely tired, asleep more than awake, terrible pressure felt on the top of my head daily, stuck with it for 5 months in the hope it would settle. No such luck in my case… could say it was worth trying, however, it really, really wasn’t. Wish I never used it at all."

1 / 10
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  • Kel...
  • Taken for 5 to 10 years
  • April 12, 2023

For Ankylosing Spondylitis "Treating ankylosing spondylitis - took a long time to diagnose, but once I was, it explained the pain and stiffness, lethargy I experienced. I used to rest to reduce back pain, which was obviously the wrong thing for this condition. So, along with an increase in activity, I started Simponi (Golimumab) after suffering for about 7 years with the disease. I have now been on it for over 6 years or so and have had very little to no noticeable issues. However, the change in my sleep, stiffness, and pain is considerable. Even joints not typically associated with AS are improved pain-wise (I have a lot of sporting injuries). I sometimes get some stiffness creeping in at about the 4-week mark as I am due for the next injection (4 weekly). I also take glucosamine supplements for my knees, which also improve soreness for me, and coupled with Simponi, my knees have never been so good. I have often found Simponi to actually improve flu/fever/covid symptoms, contrary to instructions about infections."

10 / 10
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  • can...
  • Taken for 10 years or more
  • December 16, 2022

For Psoriatic Arthritis "After taking sulfasalazine and Celebrex for years (also worked quite well)... Started my first biological, Simponi, 13 years ago, and it was a life changer. I have lived pain-free and clear skin since the day after I took my first shot. I know for me it gave me a quality of life I had only dreamed about for years. Wouldn't change it for anything. Sometimes the risk brings rewards. This was the case."

10 / 10
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  • Bob...
  • September 29, 2022

For Ankylosing Spondylitis "I’ve been using Simponi for almost 10 years now. Since starting, my back, neck, and hip pain has gone from an 8/10 to a 2/10, and my energy has almost doubled. It’s been life-changing. Side effects for me included psoriasis, hair loss, and weight gain. Well worth it, though, to not always be in constant and debilitating pain all the time. After 10 years, I’d say it’s still about 90% effective."

9 / 10
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  • Kay...
  • Taken for 6 months to 1 year
  • December 23, 2020

For Ulcerative Colitis "Simponi has been a godsend! Prior to starting Simponi, I was unable to leave my home for any length of time. I had suffered for 2 years with UC and failed other treatments. My last C-scope in November 2020 was the best of the last 4. ❤ If I had one suggestion, it would be to package alcohol swabs with each injection (like Humira does)."

10 / 10
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  • Jim...
  • September 24, 2020

For Ulcerative Colitis "Been on Simponi for 3 months, 5 tubes. I think I'm worse than before. Bloating and going to the toilet more often! I’ll give it another 3 months, but I can tell it's not working. I know someone who also had no success with Simponi, but might with Humira."

1 / 10
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  • Anonymous
  • Taken for 1 to 6 months
  • December 10, 2021

For Psoriatic Arthritis "I have gotten worse while taking this drug. My skin is far worse, and I’m incredibly itchy. I’ve suffered 2 severe middle ear infections and pustule psoriasis that I never had before in places I never had problems. I took 4 doses altogether. The side effects are not worth it for me. I’m happy it works for some people, unfortunately, I am not one of them."

1 / 10
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  • Anonymous
  • Taken for 1 to 6 months
  • August 18, 2023

For Ankylosing Spondylitis "Using it for 3 months due to spondylitis and I haven't been feeling this good for a long time. My range of motion is much better and my neck and back pain is a lot better. A few things that I've noticed are that I had an infection that progressed very fast, but after antibiotics, it was cured. I'm also getting a lot of small scrapes on my skin on the hands and face."

8 / 10
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  • FHP...
  • Taken for 5 to 10 years
  • September 18, 2021

For Ulcerative Colitis "Been on Simponi for over 10 years. It has worked miracles with my UC. Full remission. Now I have major joint pain. It started about a year or so ago in my left thumb joint. Now the pain is in every joint except one shoulder, all within the last 8 months. I have no idea what is going on, but the pain from the joints is becoming greater by the day. The docs say age. I'm 62 and no history of RA in the family, but who knows."

7 / 10
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  • Dou...
  • Taken for 5 to 10 years
  • September 9, 2024

For Ankylosing Spondylitis "I have been taking monthly injections of Simponi since 2017 after switching from Remicade at my rheumatologist's suggestion, due to minor side effects. Simponi has done an amazing job alleviating the pain of ankylosing spondylitis, and I have had no further side effects."

10 / 10
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  • Avi...
  • Taken for 1 to 2 years
  • November 5, 2024

For Rheumatoid Arthritis "My experience has been, for the most part, positive. I have experienced a few side effects: psoriasis on my scalp and face, chronic infection in my nose. However, pain in my body has decreased by half, and I can wear my wedding ring again. Flare-ups are not near as debilitating."

6 / 10
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  • 8 m...
  • Taken for 6 months to 1 year
  • November 7, 2024

For Ankylosing Spondylitis "Taking for 8 months, has completely stopped flares in its tracks. Sometimes able to lift heavier objects without pain and can sleep on my side for short periods again. But having psoriasis on scalp and some kind of sores on skin now. Will space injections out to see if sores/bumps clear up. Taking every 5 weeks."

9 / 10
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  • Cha...
  • January 16, 2010

For Ankylosing Spondylitis "Works well and helps mobility. You can feel it working in 2-3 days. Also, the injection process is quick and pain-free. Thanks for the second chance at a bearable life."

9 / 10
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  • Anonymous
  • September 28, 2012

For Rheumatoid Arthritis "Second injection today. After the first injection, I felt results in two weeks. I am very happy."

9 / 10
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43 Report
  • Dan...
  • Taken for 2 to 5 years
  • January 8, 2020

For Ankylosing Spondylitis "I was skeptical about trying Simponi at first. But I'm glad my rheumatologist encouraged me. It works awesome! Made me realize what 'normal' is again. I take 50 mg every 3 weeks."

10 / 10
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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.