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Tri-Sprintec and Nausea: What Users Say

Nausea: mentioned by 202 users (24.0%)

Based on user experiences from 841 Tri-Sprintec reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

acne 24.4%
nausea 24.0%
mood swings 23.9%
weight gain 19.0%
depression 16.3%
cramps 12.6%
headaches 11.4%
anxiety 11.2%
sore breasts 8.3%
sexual dysfunction 8.1%

Reviews for Tri-Sprintec

Commonly mentioned side effects
  • Eli...
  • Taken for 1 to 6 months
  • May 3, 2020

For Birth Control "I was on the Xulane patch for a couple of months, and my period never regulated. I was also very sad and tired on Xulane (to the point where my family started to notice changes). I switched to Tri-Sprintec one month after stopping Xulane. I did have some side effects when starting the medicine, e.g., nausea and fatigue. Overall, I really love this birth control. So far, I’m not pregnant. Remember, everyone can experience different side effects! Don’t let these reviews scare you. Give your body a chance!"

9 / 10
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  • Anonymous
  • December 17, 2009

For Birth Control "Within the 1st week I went from a happy, optimistic girl, to a very unhappy, unstable individual. My experience: crying for no reason, complete misery, severe weight gain, antisocial, exhausted, nauseous, dry eyes, high anxiety, NO sex drive, painful sex, cramping, bloating, irrational behavior."

1 / 10
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140 Report
  • Lil...
  • June 7, 2016

For Birth Control "I have had absolutely no problems with Tri-Sprintec. I don't have any side effects at all. No weight gain, no mood swings, no depression, no anxiety, no nausea, same sex drive. (No increase in breast size either - I WISH I had that side effect!) I feel exactly the same taking this as I did not taking any birth control. The only difference is my periods are lighter and shorter, and my cramps are no longer severe. By the way, I was really scared to take this because of the negative reviews I read! But before you decide this is a bad pill, give it a try. Every woman's body is different, and your experience will just depend on your body!"

10 / 10
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50 Report
  • Kai...
  • Taken for 1 to 6 months
  • February 10, 2020

For Birth Control "This birth control for me has only really done me a few favors, and that’s being free and not getting me pregnant. However, that being said, the side effects I can’t justify. I recently turned 18 and started taking the pill. My first month was fine, but the more I take it, the worse I’m getting. I’m having constant anxiety and panic attacks. I always feel extremely worried, stressed, and overwhelmed. I’m very irritable and impatient, not to mention it gives me horrendous headaches and recently extreme nausea and vomiting. Not to get into too much detail, but just absolutely projectile vomiting everywhere. Feeling very feverish, hot, and cold sweats, not to mention for period cramps, it does nothing. My cramps feel just as bad as they were before, and my period is just as heavy and maybe even a little longer. My sex drive has definitely decreased, and sex is painful, I nearly bleed a little each time. It’s causing me to go crazy, and I have trouble even sleeping with some of the symptoms."

2 / 10
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32 Report
  • Kyr...
  • Taken for 1 to 6 months
  • July 7, 2014

For Birth Control "As of today, I have just started my first placebo pill in my first month of Tri-Sprintec. For the first week or two, I noticed increased nausea and breast tenderness, the nausea subsided, but the breast tenderness still lingers (just not as bad). I got on this birth control in June to prevent pregnancy, so far, for the whole preventing pregnancy, it's wonderful. Periods come right on time, and I had no clue of her arrival (no cramps, moodiness, etc.), which I love! Since I've been on it, the past month I have actually lost 16 pounds, and I am quite alright with that. I have decreased appetite, which is also a good thing because before I started birth control, I would eat every chance I got. Overall, this pill is great! You just have to try it out for you!"

9 / 10
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53 Report

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  • Han...
  • July 25, 2014

For Birth Control "This pill has been great. It keeps my period very regulated, and I went up a cup size within the first couple of months. I have suffered from moderate acne since I was a teenager, and since taking the pill, my face is completely clear! I will occasionally get a pimple around the time of my period, but NOTHING like I had before. It is magic! The nausea was mild-moderate during the first few months, and I still occasionally feel mildly nauseous (nothing unmanageable, though). My appetite has changed as well (I don't crave sugar as often as I used to). I feel like it helps stabilize my mood in general as well, but I do cry more often than I used to (during period time). All in all, great method!"

9 / 10
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  • Anonymous
  • Taken for 2 to 5 years
  • January 14, 2013

For Birth Control "I've been taking this birth control for four years, and I started taking it when I was 16. It was my first brand of birth control, and I plan to stick with it until I want to start trying for children. I have never had much of an acne problem, but with this pill, my face is always clear. I never had any of the nausea others have written about. I do have to agree that, like others, my cup size has grown over time, and I am pleased! As far as weight goes, I don't believe this pill has changed me at all. I have stayed the same weight since high school. My hormones are crazy only the week before my period. Overall, this is a great medication for some and a not-so-great medication for others. I would not blow it off right away. I would give it a shot."

10 / 10
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42 Report
  • Ill...
  • July 4, 2021

For Birth Control "Today is my 8th day of taking Tri-Sprintec. Let me start off by saying it’s been 7 years since I’ve been on any type of birth control. I’m 31 and have two daughters, ages 6 and 2. I decided to start taking the pill again to regulate my periods and, obviously, as a contraceptive. I originally came here for the reviews on the pill’s weight gain, since I’ve been pretty bloated the last 5 days (not to mention the miserable constipation and cramping). Other than that, I used to suffer from daily headaches/occasional migraines, and I haven’t had one as of yet! My husband says he’s noticed my mood has changed for the better! My random mood swings are no more, but honestly, my headaches were the main reason for my misery. My skin has cleared up dramatically, and I haven’t been drowsy or exhausted during the day like I used to. Overall, I’d say so far, so good! I’ll post an update after I finish my 30-day pack. Lastly, I want to add I take it right before bed to avoid any nausea."

6 / 10
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18 Report
  • Jes...
  • Taken for less than 1 month
  • February 24, 2020

For Birth Control "I’ve been on Tri-Sprintec for a week. No side effects (no acne or weight gain) except I have realized that I do get moody or irritated quicker, but I try to manage it. Also, the first 3-4 days of taking the pill made me really nauseous after taking it, but then it went away after I ate something sweet. I’ll update again once I complete the month and get my period."

9 / 10
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17 Report
  • Nic...
  • November 25, 2014

For Birth Control "I've been on Tri-Sprintec for years, and my period is extremely regular, and I get it on the same day every month. Acne has always been an issue, but it has definitely lightened up a bit since taking this birth control. If I miss a pill, my body lets me know. I get very nauseous and experience cramping just because I am so reliant, in a sense, on it. Also, I never had any significant weight change at all while taking it. I also have gone up a cup size too! I've had no trouble with Tri-Sprintec and would recommend it to others."

10 / 10
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27 Report
  • Anonymous
  • September 26, 2009

For Birth Control "This is my third type of birth control pill over the last 4 years. I've gone on and off birth control, mostly because I'm not sexually active very much unless I have a boyfriend. Currently, I'm on my 5th packet. Pros: CHEAP! $9 at Wal-Mart. No taste. Easy to swallow. Periods reduced to 4-5 days when they were lasting 7-8 days before. Cons: Bad nausea and headaches on the first 3 packets. Slight breast tenderness upon resuming a new packet. Usually only lasts for a couple of days. Delayed periods. On my old birth control, I would get them the next day after stopping a packet, but now it takes 3-4 days for it to start. Painful cramps for the first day of the period. Overall, I'd recommend it. All types of birth control will give you some of these side effects."

7 / 10
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34 Report
  • Sha...
  • Taken for 1 to 2 years
  • February 3, 2014

For Birth Control "I love Tri-Sprintec! It has regulated my cycle and cleared up my skin. The first couple of months, I was a little nauseated when I took it, but that has gone away. This pill helped to balance out my hormones and actually helped me to lose weight. No complaints other than the 1-2 nights of nausea I experience when I start a new pack. Oh, and it's FREE."

10 / 10
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25 Report
  • Evi...
  • Taken for 2 to 5 years
  • December 30, 2015

For Acne "PLEASE READ THIS: Tri-Sprintec will cause an initial breakout for the first 3-4 months. DON'T BE DISCOURAGED! After this period, your skin will clear up like magic! I'm 20 years old and have been on Tri-Sprintec on/off since I was 18. I've had severe acne since I was about 12/13 years old and have seen multiple dermatologists since then. Nothing worked until I went to my gyno to get on birth control, and she recommended Tri-Sprintec because it helped with acne. At first, I felt mild nausea and severe depression/mood swings/etc., but as time passed, this went away. Each time I got back on the medication, I would have a terrible breakout period, but it's completely worth it. This is a great pill, and I've never had problems with it."

8 / 10
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22 Report
  • Anonymous
  • Taken for 1 to 2 years
  • November 9, 2013

For Birth Control "I have been on this pill for about a year now, and I just cannot deal with it anymore! I used to be so happy, but lately, I'm a different person, someone who is not nice. At first, I thought just I hadn't gotten used to it yet, but as more time has gone on, I am hateful, severely depressed, nauseated, very tired, and constantly just an unhappy person. It has affected my relationships with everyone, and the next chance I get, I'm switching to something else. I'm not saying it will do this to everyone, but I know it has been awful for me. One thing it has done is what it was supposed to do, it kept me from getting pregnant."

5 / 10
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24 Report
  • tim...
  • August 9, 2010

For Birth Control "I was on Ortho Tri-Cyclen Lo for nearly 10 years and hated the thought of switching pills (insurance purposes). I started Tri-Sprintec about 5 months ago, and I cannot tell the difference between the two. I was concerned with the nausea, vomiting, and weight gain that others talked about but had none. My face is still clear as ever, my periods are still very light, and I feel fine! Definitely worth the change!"

10 / 10
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29 Report
  • Anonymous
  • Taken for 1 to 6 months
  • August 25, 2012

For Acne "I was very skeptical about trying this pill because it is a generic, and I have heard negative things about it. I have been on it for two months, and so far, no weight gain, no nausea, no mood swings, or any other of the reported side effects. The best part about this pill is that it completely cleared up my cystic acne after only a few weeks. I have been on a couple of other pills with horrible side effects. Find the pill that works best with your body. This one seems to work best with mine."

10 / 10
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24 Report
  • Nic...
  • October 16, 2016

For Acne "Originally, I was prescribed Ortho Tri-Cyclen, but due to insurance issues, I was given Tri-Sprintec. I know you're supposed to give things usually 2-3 months to work, but let me tell you, this pill has worked miracles! The first 3 weeks were terrible. I was breaking out even worse than I already was. I mean, I was getting acne right above my eyelids, underneath my eye, and just about everywhere else on my face. I was so nauseous for a couple of days that I almost had to skip a wedding. But I am so glad I stuck to this. My face has been the clearest it's been in a year. I'm still battling 1-2 zits, but that's nothing compared to what it was. I am left with a lot of dark spots, but a few hydrafacial treatments should help with that."

10 / 10
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16 Report
  • Sar...
  • Taken for less than 1 month
  • March 3, 2019

For Birth Control "I was told Tri-Sprintec had the same ingredients as Tri-Nessa (Tri-Nessa has been discontinued), so I went with it. I’m on day 6, and it’s been AWFUL! I feel nauseous and sick all day long. My mood is out of control, and I get these horrible headaches that won’t go away. I didn’t want to believe the reviews because everyone reacts differently, but this truly is the worst pill I’ve ever been on. I don’t even think I can finish the pack, TBH. Nothing like Tri-Nessa."

2 / 10
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12 Report
  • Coo...
  • March 13, 2019

For Birth Control "Increased depression and headaches all the time. Got rashes around my face and broke out really bad. Anxiety and mood swings off the roof. Still have cramps and gained so much weight. No sex drive whatsoever and feel nausea all the time."

1 / 10
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12 Report
  • aga...
  • Taken for 6 months to 1 year
  • August 8, 2019

For Birth Control "This drug is a life ruiner. I was on Trinessa for a while and doing fine before I randomly got switched to this for no reason. Since starting this drug, I have become nauseous, lightheaded, depressed, constipated, and extremely fatigued. I can only wear loose, flowy clothing or I will get heat flashes and pass out (I'm only 21). I have headaches regularly. Anxiety tics that I worked hard to get rid of years ago are back. I have painful cystic acne that I never had before, and I've gained weight. Taking this drug almost made me fail a semester of school, and it cost me multiple friendships because I was too fatigued and depressed to leave my room and socialize. My self-confidence is at an all-time low. It is not worth it. This drug is cruel."

1 / 10
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13 Report
  • Emu...
  • Taken for 6 months to 1 year
  • May 14, 2016

For Birth Control "I was originally put on Ortho Tri-Cyclen Lo for my acne, but I couldn't afford it, so I was switched to Tri-Sprintec. Like I said, I was originally put on this for acne, but then my boyfriend and I started having sex, so I was using it for its BC effects too. It has worked WONDERS. My acne has cleared up, I'm not pregnant (you need to take it regularly though! Don't forget!), no mood swings, and my periods are shorter and lighter. However, I didn't experience the GOOD side effects until after 3 months in! I was moody, bloated, and nauseous, but my body needed to get used to it. I encourage you to try and stick it out for a bit if you just started and are feeling that way. Keep up with it, and maybe you'll like it too!"

9 / 10
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14 Report
  • Anonymous
  • October 1, 2012

For Acne "My gyno initially wrote a prescription refill for Ortho Tri-Cyclen (which I had been taking for years), but when I went to have the prescription refilled, the pharmacy did not have Ortho in stock. Therefore, they suggested the Tri-Sprintec. Just days after starting the pack, I experienced the WORST breakouts I have had as an adult, along with nausea, heart palpitations, and migraines. This is simply my experience with this pill - I know every female's body is different."

2 / 10
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17 Report
  • Bab...
  • Taken for 2 to 5 years
  • March 7, 2013

For Birth Control "As far as birth control, it is an extremely effective contraceptive pill! Never got any severe side effects; some nausea the first week, but that's about it. Also, my periods are about the same flow-wise, but very little cramping, about 4 days long instead of 5. I used to have awful skin, and now it is clear! The only thing that happened when I went on this medication that may be displeasing to others is that I gained about 30 pounds. My varying weight before was 106-110, and now I am between 130-136 lbs."

10 / 10
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18 Report
  • Aba...
  • Taken for 1 to 6 months
  • April 30, 2021

For Acne "Initially, I was scared of trying Tri-Sprintec just because of the terrible reviews I saw and my previous experiences with BC pills (nausea, depression, diarrhea). But this pill is awesome! Apart from a few days of nausea and some initial breakouts, I had no mood swings, no weight gain. After the second week, my skin cleared up, and my boobs got slightly bigger too! All in all, great birth control. Would 10/10 recommend."

9 / 10
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8 Report
  • Anonymous
  • December 13, 2009

For Birth Control "I've been on Tri-Sprintec for 1.5 months now. The plus is that Tri-Sprintec doesn't make me want to put a period to my life, like my last birth control did! Side effects include bad nausea for the first month, and my period randomly started too early just yesterday (2nd week of my 2nd month). But overall, I'm satisfied - no major weight gain that I can tell, and no acne. I'm planning to wait 3-4 months to see whether the side effects level out. I join with others in saying that every woman's body is different. Read these posts to get a sense of some common side effects, but don't panic if something different happens, and be glad if nothing happens at all! Call your doctor to make sure your symptoms aren't anything to worry about."

9 / 10
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19 Report

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