Trulicity and Vomiting: What Users Say (Page 3)

• Amy...
• June 19, 2017

For Type 2 Diabetes "The day after my first injection, I was so exhausted that I slept the entire day. Two days after the injection, I vomited all day. I'm currently on day 3 with extreme nausea and diarrhea. I will not do this again! This is horrible!"

• mil...
• July 17, 2017

For Type 2 Diabetes "I did fine until the first shot of increased dosage. Two days after the injection, I had severe diarrhea and vomiting. I had one walk-in clinic visit for fluids. Two ER visits, with the last ending in admittance to the hospital with five more bags of fluid. I wouldn't suggest anyone take the increased dosage if the smaller dosage is working. Actually, I wouldn't recommend it to anyone."

• Mel...
• Taken for 1 to 6 months
• December 31, 2019

For Type 2 Diabetes "I've been on 0.75 mg Trulicity for a month now. I take my shot on Sundays and feel fine, but usually on Monday, I feel lethargic, and I have intermittent chills and sweating all through the week, especially at night, which causes me to not sleep well or at all. I don't get nauseous but have little appetite, and if I do eat something substantial, it doesn't stay down long, and without any notice, I will just vomit it all up. I have some constipation, but probably because I don't eat much. I do drink water and other fluids. I'm supposed to go to the higher dose, but my GP wants me to go to urgent care ASAP. I can't take metformin, glipizide, or Nesina. I was doing great on Janumet, but then started vomiting for weeks straight, and now Fidelis won't pay for it anyway."

• Gol...
• April 19, 2017

For Type 2 Diabetes "Unfortunately, after 3 doses, I had to stop this medication. Initially, I did experience nausea, but I could deal with that, it was into the third week that I started to experience severe stomach pain, and I was so ill with real vomiting, cold sweats, shakes, etc. The pain would not go, so the doctor had to be consulted, and apparently, because Trulicity slows the metabolism, my stomach wasn't emptying properly and causing all the problems. The pain was so severe at one point I really thought I had a serious condition!!!"

• Mis...
• Taken for less than 1 month
• April 14, 2019

For Type 2 Diabetes "I took the Trulicity injection 1 time on March 16th, 2019, and then 24 hours later, I'm in the emergency room with upper abdominal pain, nausea, and vomiting. I saw my own doctor 3 days later and drew blood work, and my liver was very inflamed. I was continuing to throw up and still in pain. Back to the emergency room and more blood work. Back to the doctor’s office every week. I just had an upper endoscopy and now have a hiatus hernia, and my stomach is irritated, and I don't know why, so they took biopsies. I have been miserable since I took the injection."

• Swe...
• January 26, 2016

For Type 2 Diabetes "First 6 weeks was on 0.5, had a little cramping, headaches, mild reflux, nausea, this usually happens on the 2nd day after the injection. My blood sugars were so excellent that my insulin pump would have low readings at night. My appetite was no longer, and I was losing weight. Then on the 7th week, the dosage went up to 1.5. Well, let's just say I ended up in the ER. My cramping was horrible, didn't get any sleep because I was projectile vomiting, diarrhea, heartburn, muscle tightening, and severe headaches. I became extremely dehydrated, so for 3 days, I was a mess. But in all, my sugars stayed regulated and would only recommend staying on the 0.5. I don't know what my A1C is yet, but blood sugar numbers are excellent. Side effects not worth it."

• Nan...
• Taken for 1 to 6 months
• June 27, 2018

For Type 2 Diabetes "I have been on Trulicity for about 2.5 months! The first shot was a little nausea and very tired. But was somewhat okay. Well, I took my last shot Thursday, and by Saturday, I was the sickest I have ever been! Vomiting and severe pain in my stomach and back! Admitted to the hospital. I am home, and the nausea is still terrible. Don’t take it! Please!! Bad stuff!"

• Oli...
• Taken for less than 1 month
• November 20, 2016

For Type 2 Diabetes "Holy moly. I am 4 weeks into this medication, and I feel horrid! My doc told me to stick with it. First week, I vomited and felt like I had the flu for 4 days. The second injection was just a little motion sickness. The third injection, I had horrible diarrhea and nonstop vomiting. I just don't know how much more I can take. My blood sugars have been perfect, though. I just can't deal with all the vomiting."

• Lun...
• Taken for less than 1 month
• February 17, 2020

For Type 2 Diabetes "Took my first Trulicity injection this past Friday. Felt horrible ALL weekend and not able to do anything; barely got off the couch! Have terrible nausea, vomiting, and diarrhea. Lost my appetite and not keeping food down. I have also had a terrible headache since Saturday. Taking this is worse than the actual condition. Will no longer take it. I cannot work like this!"

• wil...
• Taken for 1 to 2 years
• June 24, 2017

For Type 2 Diabetes "I have been on Trulicity for 15 months now and am very happy with the results (1.5), but don't like the side effects. For the first 2 months, I was sick for 1 or 2 days after each injection, with vomiting and diarrhea. But after that, I only had the nausea and vomiting once every month or two. I do still have loose bowel movements fairly often. I have neuropathy in my feet and hands, so I am very happy with my lower A1C (last one was 4.6). My endo has lowered my preprandial Humalog and Levemir to keep my blood sugar up around 90 to 100. I was having lots of sub-50 blood sugars."

• Den...
• December 14, 2016

For Type 2 Diabetes "I've been on this drug about four weeks now, just gave my fourth injection yesterday. First injection wasn't that bad, felt nauseated for two days, lost appetite, had to remind myself to eat, but I was fine the rest of the week, and such a remarkable improvement on my blood glucose results. Second injection was very nauseated, but no vomit on the first day. Second day, woke up at 4 a.m. feeling sick to my stomach, shaking, sweating, my BS was 130 mg/dl. Vomited like endless, then was fine again the rest of the week. Third injection, felt much better, a little nausea the first two days, then fine. I've lost 4 lbs in four weeks, my BS number averages 110's, A1C dropped from 8.4 to 7.2 in three weeks. It's a very expensive drug, but I think it's worth a try."

• Ali...
• Taken for less than 1 month
• December 14, 2016

For Type 2 Diabetes "Glad to see I'm not alone in the side effects. I started with 0.75 for two weeks and seemed to be doing okay with some of the side effects, but tolerable enough for me to go to the next level, which was the increased dosage of 1.5. Mistake! I had severe nausea, diarrhea, and some vomiting for the whole week. I felt like I was taking an endless colonoscopy prep. On the advice of my doctor, I did not take the next injection and waited a full week to feel better. This week I restarted the lower dose again and am hoping for the best. If this remains tolerable and once my A1C has been retested again, I may only need the lower dose. Keeping my fingers crossed. I did lose a couple of pounds during the week of horror. Will keep you posted."

• Koo...
• Taken for less than 1 month
• August 27, 2018

For Type 2 Diabetes "Started Trulicity with the first dose of 0.75 and did okay, but around day 5-6, felt very nauseous and constipated. Next dose of 0.75 did okay, but again around day 5-6 felt nauseous, could barely eat because I felt very bloated, like I had eaten a Thanksgiving dinner. Of course, blood sugars were good because I couldn't eat. Then I took the 1.5 dose... day 5 constant vomiting to the point I was so sick I could barely walk. Never felt this bad in my life. My wife is a nurse and she ran 2 bags of IV fluid in me and then took me to the ER. They gave me some medicine for nausea and ran more fluids through me. My white blood count came back fine, which told me this wasn't a virus or infection, it was Trulicity. I urge you not to take this medication. If you start having problems with the first 2 doses, then stop. Because once you double the dose, you are probably going to end up very sick and in the ER."

• MAS...
• Taken for 6 months to 1 year
• November 4, 2018

For Type 2 Diabetes "I started on Trulicity in December 2017. It has worked great. Lost 25 lbs. HbA1c dropped from 8.2 to 6.2. Side effects: tired a lot. Diarrhea or constipation comes and goes. Feel a little nauseous on the first day after the shot, but only vomited once in all these months. Last 2 weeks, I discovered a yeast infection - not sure if it is related. I am 67 years old and have been Type II since 2003. I also take Metformin ER and Jardiance. Insurance covers part of my cost. Overall, I would highly recommend."

• dan...
• March 14, 2017

For Type 2 Diabetes "First dose of .75 of Trulicity is my last. Only able to work 1 day out of 8. Doctor really downplayed the side effects. Vomiting every day, can't eat (or keep down any food), diarrhea is the consistency of water. Absolutely a hateful drug!"

• Fru...
• August 9, 2016

For Type 2 Diabetes "I have been on Trulicity for four weeks, minus one week I did not have a sample because my insurance won't pay for it. The first two weeks were great! I did have waves of nausea, but my sugar was down, and I felt so much better. I lost a few pounds, but I was trying to, and my appetite was not very much. Above all, I had consistent readings below 200. Then everything changed over the last week. I started feeling depressed and very tired, to the point of exhaustion, and I felt horrible constipation. Saturday I actually had a decent meal and woke up Sunday feeling horrible. I could not get any relief from the constipation. Now the vomiting all night and day. Not sure if I will stick it out. So sick."

• Rig...
• April 9, 2017

For Type 2 Diabetes "On week five of Trulicity. The first night I was beyond exhausted, went to bed at 7 pm, slept all night. Week 1 had every symptom and was so sick: vomiting, diarrhea, and this deep gut burping that smelled horrible. Week 2 was better, but week 3-5 are hit and miss. I have lost about ten pounds, mainly due to little to no appetite. I take my shot on Tuesday, and I vomit every Saturday. I miss about 1 day of work a week due to feeling horrible and dizzy. This drug is horrible, but my sugar with other meds is down to 7 from 9.8 in 3 months. The burping is the worst, it's like rotten eggs... so gross."

• Whi...
• Taken for less than 1 month
• April 10, 2018

For Type 2 Diabetes "Terrible experience. Shortly after taking on a Sunday, I was extremely fatigued. Lost all appetite the rest of the day and Monday. Constant hiccups and burping, acid reflux was so bad by Tuesday night it woke me up coughing it up. Appetite started to reappear by Wednesday, so had a smaller normal meal in the evening. Early hours of the morning, projectile vomiting and diarrhea. After reading reviews here and seeing that thyroid cancer is a risk, contacted GP. Advised to discontinue. Felt unwell and like a zombie all week. It's very worrying that there are no long-term studies of this medication in humans. It causes cancer in mice and rats. Because it hasn't been tested, it's not known if it will cause cancer in humans. So we're all guinea pigs."

• Pet...
• Taken for less than 1 month
• September 30, 2018

For Type 2 Diabetes "First time I took Trulicity on Friday, by Sunday, I started vomiting and could not stop. Had to go to the ER for help. I talked to the doctor, and she said I could try a second dose. Did this on Sunday, 9 days after the first dose. Within 24 hours, the vomiting started, and again I had to go to the ER for fluids and meds to stop the vomiting. So it was the Trulicity!!! Will never take it again."

• Ags...
• Taken for 6 months to 1 year
• October 10, 2018

For Type 2 Diabetes "Started Trulicity in April 2018. My A1C was 7.8 and on a continuous climb upward. At my three-month check in July, it had dropped to 6.2. Today (Oct. visit), my A1C was 5.9. My doctor is reducing my other meds. That is without much diet or exercise change. I have not really lost weight with it, but I have not had nausea, vomiting, etc., which really causes the weight loss."

• Deb...
• April 18, 2017

For Type 2 Diabetes "Well, I am 24 hours into the shot and so far (knock on wood) the only side effect is headaches (which I never have), but I can deal with that. My morning blood reading would normally be about 169, and I got up this morning, and it was 75. Just wondering how many days into it the side effects (nausea & vomiting) started with people that did experience these effects? Will keep you posted after the week is up....."

• Mam...
• Taken for less than 1 month
• June 5, 2016

For Type 2 Diabetes "I was given this 'new miracle drug' by the NP in my MD office last Tuesday. After reading the reviews on Trulicity, I was wary since I have allergies and sensitivities to other drugs and foods. The NP was pretty adamant that this drug would really work for me, so I agreed. I gave the first shot on Wed. night about 8 pm, and by 10 pm the nausea started. By midnight, I was vomiting steadily and spent the whole night in the bathroom! Nothing stayed down, not water, Gatorade, or crackers...even Phenergan (RX nausea pill) came back up. Missed work Thurs, miserable at work Fri, and still sick on Sunday...off to Urgent Care now to try and fix this. Don't take this drug unless you want to be horribly sick for days and can afford to miss work!!"

• Ali...
• Taken for less than 1 month
• March 26, 2019

For Type 2 Diabetes "I have been taking Trulicity now for 3 weeks. My first injection I took on a Friday, and by Sunday I was violently ill with diarrhea and vomiting that lasted 3 days. I was resistant to take it again on Friday, but did, and all side effects are gone. I have to up my dose this Friday, so we will see how that goes. I am hopeful for this medication because I have suffered from high sugars and weight for many years."

• TMo...
• Taken for 6 months to 1 year
• May 16, 2023

For Type 2 Diabetes "I have been taking Trulicity for almost a year. I was on the 1 mg dose at first, but in February of 2023, my doctor upped the dosage to 3 mg. I vomit EVERY day, sometimes multiple times on this drug. I take a prescription nausea pill daily, so it is easing up. Other than nausea, Trulicity has worked wonders for me. My A1C is 6, and I have lost 15 lbs since March 2023 and am still losing. My doctor said I could go off of it if the nausea is too bad, but I'm gonna be a trooper and stay on it because my numbers have never been better."

• maw...
• May 23, 2015

For Type 2 Diabetes "Been on for 3 weeks, take shot on Mon. Side effects started on day 3. 2nd week, day 4, this week, day 5. Upset stomach, vomiting, extreme nausea! Nothing helps! Horrible belching and gas! Cannot function on those days. Blood sugars are great! The jury is still out. Do these effects go away after a while?"