Trulicity and Diarrhea: What Users Say (Page 5)

• Big...
• Taken for 1 to 6 months
• September 7, 2019

For Type 2 Diabetes "After the second 0.75 mg dose of Trulicity, I experienced sulfur-like burps/indigestion, explosive diarrhea, total loss of appetite, and light-headedness. I contacted my doctor and was told it was the Metformin causing these side effects, I disagreed and stopped taking the Trulicity after 1 month."

• Dal...
• Taken for 6 months to 1 year
• May 24, 2024

For Type 2 Diabetes "I have been on diabetic medications for over 3 years and finally moved to Trulicity because of supply problems with Victoza. Initially, the side effects began developing over the first few weeks of using 1.5 mg injections, and I still get some side effects like tiredness, abdominal pain, nausea, constipation, or diarrhea within the first 48 hours of taking the medication. Sometimes the side effects are mild, but other times, it is quite debilitating. For the first few months, my blood sugar dropped to the point where my diabetes went into remission due to stopping medication that aggravated my blood sugar and starting Trulicity. Now, almost a year on Trulicity, supply problems have, again, hit this medication, and my blood sugar is slowly rising. The advantage of Trulicity is easy to use. My daily blood sugars fluctuate, but not as bad as before taking Trulicity. Overall, I prefer Trulicity over Victoza. Disadvantages are the side effects, supply issues, and I have found it only works for about a year."

• Lyn...
• November 23, 2016

For Type 2 Diabetes "I gave my first shot of Trulicity .75 last Wednesday evening. By Friday, I was absolutely sick to my stomach, accompanied by nausea. Finally took nausea medication, which helped. But later threw up. I have had severe diarrhea any time I eat something. Burping all day, and Sunday I could barely get out of bed, my energy was not there, and my body ached. Unfortunately, my 2 kids don't understand, so up and out of the house I went to buy a Gatorade, and I actually felt better after drinking a little. I'm afraid to take my dose tomorrow because I'm not sure I can deal with another week of these side effects... But they said to keep with it and your body will adjust... any advice if this is true?"

• Tbo...
• July 26, 2017

For Type 2 Diabetes "I just started Trulicity last Sunday. I went to a new endo doctor and told her that my A1c is not coming down, and my fasting blood sugar is up. So far, the only side effect was dry mouth the next day. I did have a little diarrhea, but I can't say if it's from the Trulicity or the metformin, because the metformin does give me GI issues. On a good note, I'm down 3 lbs, and my fasting morning BS is way down. So far, so good. I'll keep you posted."

• der...
• Taken for 1 to 6 months
• July 6, 2017

For Type 2 Diabetes "Addendum to June 13th post: My A1c is 7.2, down from 9.2 in May. That's 2 points in 2 months. Yay!!!! My Endo was very pleased. He started me on Trulicity 0.75 in May because I was having GI issues with Janumet. I've had no nausea or diarrhea with Trulicity. Only mild headache, decreased appetite, some abdominal soreness/achiness, and low blood sugars during the day. Now, I take 5-10 units of Novolog prior to meals and at times none at all depending on my blood sugar reading. My Levemir has decreased as well-I take 42 units at night vs. the previous dosage of 50 units twice daily. My weight is down 6 lbs. I recently filled a prescription for a 90-day supply of Trulicity and did not have a co-pay. Overall, I am pleased."

• Daw...
• May 22, 2019

For Type 2 Diabetes "I’m on my second week of Trulicity, and I called my doctor today to inform her that I wasn’t going to take it anymore. After my first dose, I had bad stomach pains, heart beating fast, nausea, diarrhea, and felt really bad. I just can’t take it anymore. I also had shortness of breath."

• Sdm...
• Taken for less than 1 month
• May 4, 2019

For Type 2 Diabetes "My A1c crept up to 7.4 after 4 years on Metformin, and the doctor suggested Trulicity in addition to staying on Metformin. After 6 straight days of Trulicity-induced nausea, cramping, diarrhea, fatigue, little appetite, leaving me weak, I honestly do not think I can handle a second week. Slight decrease in morning fasting, so I am just not sure what I’m going to do... Ugh."

• Pap...
• Taken for less than 1 month
• August 24, 2018

For Type 2 Diabetes "I was put on Trulicity and have taken two doses. Four days after taking the first dose, I developed a sour stomach when I belched, and I belched a lot. Immediately, my stomach started burning, and I had heartburn and a lot of gas in the stomach. Very painful. Then it seemed to move to my intestines, where I felt burning, gas, and eventually diarrhea. This lasted for about five days, then the symptoms subsided. Then I took my second dose, and four days later, all the symptoms came back with a vengeance. Can't live like this. No more for me."

• Ali...
• Taken for less than 1 month
• March 26, 2019

For Type 2 Diabetes "I have been taking Trulicity now for 3 weeks. My first injection I took on a Friday, and by Sunday I was violently ill with diarrhea and vomiting that lasted 3 days. I was resistant to take it again on Friday, but did, and all side effects are gone. I have to up my dose this Friday, so we will see how that goes. I am hopeful for this medication because I have suffered from high sugars and weight for many years."

• Sue...
• Taken for less than 1 month
• August 27, 2017

For Type 2 Diabetes "I took Trulicity 1.5 for the first time Wednesday. Within hours, I felt sick, tired, and had the most awful headache. I slept most of the day, no food. Thursday, I woke feeling hungover. I made a coffee and was immediately sick. A lump appeared in the side of my neck, went after a few hours. Friday, I felt better, had some toast, but then the watery diarrhea kicked in. Saturday, I managed one Weetabix. By lunchtime, I fancied a Happy Meal (don't know why, as I've never wanted one before). Big regret, as I suffered bad diarrhea all day and slept all day and night. Sunday, still no appetite, not so tired, diarrhea subsided, slight headache, but I've lost 5 lb. My sugars are a consistent 5, and I've reduced NovoMix from 90 units to 40 units. Will I take it Wednesday? I'm not sure."

• Atv...
• November 9, 2016

For Type 2 Diabetes "I took the smaller dosage of 0.75 mg, thank God. The first two days were fine, then the third day everything went south. Blood sugar was 219, the highest I had ever taken. Woke up with an upset stomach, then diarrhea for 6-8 hours, then vomiting for 4-6 hours, then cold chills, a rash that turned to hives from crotch to knees, armpits to elbows, head itched, lips started getting puffy. This was all in 24 hours. It was horrible. Then the next 9 days it took to get completely out of my system. Every day I would have these with less severity. The hives were the only thing that did not recur. At times, I could not stand any clothes on, my body was that sensitive. I found from the doctor at the emergency room that the half-life of the drug was 5 days."

• Rob...
• Taken for less than 1 month
• July 23, 2015

For Type 2 Diabetes "I ended up in the ER with the worst case of the runs I have ever had in my 51 years! I can't imagine how or why you would ever consider this injection. Why is it called (medicine)? I literally couldn't sleep. I would lay down in bed, as we all do, and within 5 minutes be up and on the toilet! Every 5-20 minutes like this for 3 days so far! I'm so tired! If I fall asleep on this injection, I WILL lose control of my bowels, and I have, 6 times in the bed. FIRST WEEK WAS OKAY... Second week, the runs on Tuesday (injection on previous Sunday). Same time on the third week of use. Same results, and trip to the ER. If you like the thought of buying a new bed, then inject this medicine into your body. How humiliating!"

• nug...
• Taken for less than 1 month
• October 9, 2016

For Type 2 Diabetes "I did my first shot 10 days ago. Side effects were the worst I've ever experienced on a medicine: extreme nausea, headache, vomiting, and the diarrhea was extreme and very bad smelling with bad smelling sulfur-like burps. I thought maybe I caught a bug, but after reading others' side effects, I'm sure it was the shot. My husband is totally against me taking it again, and I'm now agreeing with him. Yeah, my sugars went down because I couldn't eat for almost 9 days, and nausea medicine didn't help at all. You lose weight because you can't eat. I was really hoping this would help because I don't want to go on insulin. I finally took something for the diarrhea and am feeling almost normal again."

• Osc...
• March 23, 2017

For Type 2 Diabetes "I just want to say what a horrible experience using Trulicity. Every single side effect happened to me, and I used the low dose one. I had nausea, diarrhea, vomiting, upper, lower, and mid-abdomen pain. It was so bad that I dragged myself to my doctors, and they had to call an ambulance because my BP dropped to low levels. The nurse said I looked green. I got dehydrated, and a week after, my stomach was still gassy and in pain. I hope it works for some of you, but if you are considering it, be advised, I lost an unhealthy 12 lbs in a few days."

• Anu...
• December 24, 2015

For Type 2 Diabetes "I have been on this for 3 weeks, and I had nausea and diarrhea on the second days of the injection. I have a dull pain in my lower left abdomen. My sugar levels have gone down, but it wears off towards the end of the week."

• SW...
• Taken for 1 to 6 months
• June 20, 2018

For Type 2 Diabetes "Took this med for 6 weeks. Dropped 4 pounds and lowered appetite. Drastically increased migraines; had to file intermittent FMLA (the Family and Medical Leave Act form) for work so I didn’t get fired. Got severely constipated, then weekly severe cramping/diarrhea to finally move bowels. This also increased anxiety and depression. This med was stopped and changed to Victoza. Still suffering the migraine aftereffects until it is completely out of my system. Injection is super painful (like a 4-second bee sting). Had to work myself up to administering it weekly. Have more energy now that I’m off med. Anxiety and depression back to normal. Been off now for 1 week 5 days."

• Ang...
• March 12, 2022

For Cardiovascular Risk Reduction "I have been on Trulicity for about 3 months. The worst 3 months of my life. After having severe stomach pains, I was referred to a surgeon to have an endoscopy and colonoscopy after a CT scan showed acute pancreatitis and numerous other stomach issues. The surgeon only told me I needed to review my medications with my doctor, never once telling me of the complications with Trulicity! I experienced every side effect from blurred vision to severe cramping, abdominal pain, racing heartbeat, fatigue, and constant diarrhea. This drug needs to be removed. I have been in so much indescribable pain that anxiety and depression kicked in, not knowing what was wrong. I am waiting for it to leave my body. This has been a complete nightmare."

• cha...
• Taken for 1 to 6 months
• March 14, 2018

For Type 2 Diabetes "First month at 0.75: nausea and diarrhea, but results of blood tests were great. One month later on double dose. I still am nauseated the first couple of days, but I can manage. After a large meal, I will have cramps and diarrhea, but it does not last. I still feel the benefits outweigh the negative. The side effects are more noticeable if I inject in my abdomen...better to inject in my thighs."

• Gra...
• Taken for 1 to 2 years
• December 30, 2021

For Type 2 Diabetes "After Metformin was no longer keeping my numbers down, my doctor suggested we add a new medication. He gave me a sack full of free samples of Trulicity. He said it was wonderful and should get me back in line. I started out on the lower doses, then eventually went to the 1.5 dosage until my numbers started creeping up again. That was about the same time that the 3.0 and 4.0 dosages had first been approved. I was put on the 3.0 dose. It brought my numbers back down, but the side effects were magnified and became intolerable. I ended up with heartburn so bad I started having to take daily heartburn medication. Then I started having severe episodes of what I initially thought was food poisoning. I had sulfur burps with severe vomiting and diarrhea so bad I had to wear adult diapers during those episodes. It turned out to be medicine-induced gastroparesis and pancreatitis. The once weekly shot was convenient but not worth the horrific pain and suffering it caused."

• BBa...
• Taken for 1 to 6 months
• June 10, 2019

For Type 2 Diabetes "I have been using Trulicity for two months. I had two bouts of diarrhea, but other than that, all has been good. The injections are so painless, sometimes I have to check to see if it went in! No side effects. I don't know if I've lost weight, but my appetite is much smaller. I don't have extreme highs or lows anymore. I am happy with Trulicity!"

• Pan...
• Taken for less than 1 month
• June 16, 2019

For Type 2 Diabetes "Avoid at all costs unless you want to feel very poorly! On 1st day of taking it I felt light-headed. 2nd day I was puking up and had harsh abdominal pains. 3rd day I felt very bloated and was letting out burps that smelled like sewage. The bloating is causing me pains from my lower abdomen to my chest. Also got bad diarrhea flushing out lots of water. I am on the 6th day after having my 1st injection and am still very bloated and in pain. Will not be taking Trulicity again!"

• mag...
• Taken for 1 to 6 months
• June 8, 2019

For Type 2 Diabetes "I'm not sure how to rate Trulicity. It's done a great job in reducing blood sugar (my blood sugar is an average of 146, down from almost 200 average). A1C is 7.1, down from 8.7 in 3 months and 6 shots of 0.75 mg Trulicity in the last month and a half. I've experienced no discomfort from taking the shots, I most often feel nothing and rarely the faintest prick of the needle. The downside is the side effects that I've had: outrageous gas, vomiting, and diarrhea. Side effects start 2-3 days after taking the shot and can last up to 5 days so far. I'm going to reduce and change my diet to see if that reduces the side effects, or I'll have to try something else."

• DO...
• Taken for less than 1 month
• June 1, 2016

For Type 2 Diabetes "I got this shot during a doctor visit. Unsure if the dose was the .75 mg, but the 3 samples he gave me were of the 1.5 mg dose. Side effects began the following day: nausea, diarrhea, abdominal pain, decreased appetite, indigestion, and severe acid reflux. I also had body aches and fatigue. I dare say I felt depressed. I had just gotten over the stomach flu 3 weeks before, and it felt like I had come down with it again! Trulicity did lower my glucose levels, as did my weight (3 lbs. that week). Of course, it did! I could not eat, and whatever little food I ate, it came out in minutes! I DID NOT and WILL NOT inject myself with this again. I'm sorry I agreed to the shot. One of the worst weeks of my life!"

• The...
• Taken for 1 to 6 months
• June 15, 2016

For Type 2 Diabetes "I can agree that the fatigue is noticeable. My biggest shock was the diarrhea. I hadn't planned for it, and luckily I was at home when it hit the first time. It was akin to the flushing out one gets when they are preparing for a colonoscopy. I was noticing my abdomen growling. I am a bit lactose intolerant, and this was similar to if I had cereal with milk. Then suddenly I had THE URGE!!!! I was wearing shorts, and just made it to the bathroom and was able to jump into the shower as I knew there was no way I'd be able to drop trou and hit the toilet when it hit. It was as if a dam had opened. I just turned on the water and slowly removed my clothes as wave after wave struck. Luckily, that first time was the worst. Now I'm prepared."

• bam...
• December 4, 2016

For Type 2 Diabetes "I have taken Trulicity for four weeks now. At first, I had bad side effects: headache, nausea, diarrhea with terrible cramping. But each week it lessened. Now into the fifth week. Doing much better. Still have no real appetite, have to remind myself to eat. But my blood sugars are down! That was my main objective. Haven't lost any weight, though. But still glad that I hung in there and got through the adjustment period."