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Naloxegol

Generic Name: Naloxegol (nal OX ee gol)
Brand Name: Movantik

Uses of Naloxegol:

  • It is used to treat constipation caused by some pain drugs.

What do I need to tell my doctor BEFORE I take Naloxegol?

  • If you have an allergy to naloxegol or any part of this medicine.
  • If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • If you have liver disease.
  • If you have ever had bowel block.
  • If you take any drugs (prescription or OTC, natural products, vitamins) that must not be taken with naloxegol, like certain drugs that are used for HIV, infections, or seizures. There are many drugs that must not be taken with this medicine.
  • If you are taking St. John's wort. Do not take St. John's wort with naloxegol. This medicine may not work as well.
  • If you are taking or will be taking another drug like this one.
  • If you are breast-feeding. Do not breast-feed while you take this medicine.

This is not a list of all drugs or health problems that interact with naloxegol.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this medicine with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Naloxegol?

  • Tell all of your health care providers that you take naloxegol. This includes your doctors, nurses, pharmacists, and dentists.
  • Talk with your doctor before using a laxative with this medicine.
  • Avoid grapefruit and grapefruit juice.
  • This medicine is only for use in patients who take pain drugs. Tell your doctor if you stop taking your pain drug.
  • Signs of opioid withdrawal have happened with naloxegol. Call your doctor right away if you have more sweating, chills, loose stools (diarrhea) or stomach pain that is not normal, anxiety, irritability, or yawning.
  • If you are taking methadone for pain, talk with your doctor. Stomach problems like loose stools (diarrhea) and stomach pain may happen more often in people taking methadone with this medicine than in people taking other pain drugs.
  • This medicine may not work as well for people who have been taking pain drugs for less than 4 weeks.
  • Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using naloxegol while you are pregnant.
  • If this medicine is used during pregnancy, it may cause withdrawal in the unborn baby. A doctor will need to check on the unborn baby after naloxegol is used.

How is this medicine (Naloxegol) best taken?

Use this medicine as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • Take on an empty stomach. Take at least 1 hour before or 2 hours after the first meal of the day.
  • If you are not able to swallow naloxegol whole, it can be crushed and mixed in 4 ounces (120 mL) of water. Drink right away after mixing. Refill the glass with 120 mL of water, stir, and drink.
  • Those who have feeding tubes may use this medicine. Use as you have been told. Flush the feeding tube after naloxegol is given.

What do I do if I miss a dose?

  • Take a missed dose as soon as you think about it.
  • If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
  • Do not take 2 doses at the same time or extra doses.

See also: Dosage Information (in more detail)

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Loose stools (diarrhea) that will not go away.
  • Very bad stomach pain and diarrhea have happened with this medicine. Most of the time, these problems have happened within a few days after starting naloxegol. Sometimes, these problems have led to the need to go to the hospital. Call your doctor right away if you have very bad diarrhea or very bad stomach pain.
  • Tears in the stomach or bowel wall have happened in certain people taking drugs like this one. Call your doctor right away if you have swelling or pain in your stomach that is very bad, gets worse, or does not go away. Call your doctor right away if you throw up blood or have throw up that looks like coffee grounds; upset stomach or throwing up that does not go away; or black, tarry, or bloody stools.

What are some other side effects of Naloxegol?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Loose stools (diarrhea).
  • Gas.
  • Headache.
  • Upset stomach or throwing up.
  • Belly pain.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

See also: Side effects (in more detail)

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Naloxegol?

  • Store at room temperature.
  • Store in a dry place. Do not store in a bathroom.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Check with your pharmacist about how to throw out unused drugs.

Consumer Information Use and Disclaimer

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else's drugs.
  • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
  • Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
  • This medicine comes with an extra patient fact sheet called a Medication Guide. Read it with care. Read it again each time this medicine is refilled. If you have any questions about naloxegol, please talk with the doctor, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about naloxegol. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using naloxegol.

Review Date: October 4, 2017

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