Generic Name: Paliperidone Injection (pal ee PER i done)
Brand Name: Invega Sustenna, Invega Trinza
Medically reviewed by Drugs.com. Last updated on Feb 12, 2019.
- There is a higher chance of death in older adults who take Invega Trinza (paliperidone injection) for mental problems caused by dementia. Most of the deaths were linked to heart disease or infection. This medicine is not approved to treat mental problems caused by dementia.
Uses of Invega Trinza:
- It is used to treat schizophrenia.
- It is used to treat schizoaffective disorder.
- It may be given to you for other reasons. Talk with the doctor.
What do I need to tell my doctor BEFORE I take Invega Trinza?
- If you have an allergy to paliperidone, risperidone, or any other part of Invega Trinza (paliperidone injection).
- If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
- If you have kidney disease.
- If you have ever had a long QT on ECG or other heartbeat that is not normal.
- If you are taking any drugs that can cause a certain type of heartbeat that is not normal (prolonged QT interval). There are many drugs that can do this. Ask your doctor or pharmacist if you are not sure.
- If you are taking any of these drugs: Rifampin or St. John's wort.
- If you are taking carbamazepine.
This is not a list of all drugs or health problems that interact with Invega Trinza (paliperidone injection).
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Invega Trinza (paliperidone injection) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.
What are some things I need to know or do while I take Invega Trinza?
- Tell all of your health care providers that you take Invega Trinza (paliperidone injection). This includes your doctors, nurses, pharmacists, and dentists.
- Avoid driving and doing other tasks or actions that call for you to be alert until you see how Invega Trinza (paliperidone injection) affects you.
- To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down. Be careful going up and down stairs.
- High blood sugar or diabetes, high cholesterol, and weight gain have happened with drugs like this one. These changes may raise the chance of heart and brain blood vessel disease. Talk with the doctor.
- Check your blood sugar as you have been told by your doctor.
- Avoid drinking alcohol while taking Invega Trinza (paliperidone injection).
- Dizziness, sleepiness, and feeling less stable may happen with Invega Trinza (paliperidone injection). These may lead to falling. Broken bones or other health problems can happen from falling. Talk with the doctor.
- Low white blood cell counts have happened with drugs like this one. This may lead to a higher chance of getting an infection. Deadly infections have rarely happened. Tell your doctor if you have ever had a low white blood cell count. Call your doctor right away if you have signs of infection like fever, chills, or sore throat. Talk with your doctor.
- Some people who take Invega Trinza (paliperidone injection) may get a very bad muscle problem called tardive dyskinesia. This muscle problem may not go away even if Invega Trinza (paliperidone injection) is stopped. Sometimes, signs may lessen or go away over time after Invega Trinza (paliperidone injection) is stopped. The risk of tardive dyskinesia may be greater in people with diabetes and in older adults, especially older women. The risk is also greater the longer you take Invega Trinza (paliperidone injection) or with higher doses. Muscle problems may also occur after short-term use with low doses. Call your doctor right away if you have trouble controlling body movements or if you have muscle problems with your tongue, face, mouth, or jaw like tongue sticking out, puffing cheeks, mouth puckering, or chewing.
- Older adults with dementia taking drugs like this one have had a higher number of strokes. Sometimes these strokes have been deadly. This drug is not approved to treat mental problems caused by dementia. Talk with your doctor.
- If you are 65 or older, use Invega Trinza (paliperidone injection) with care. You could have more side effects.
- This medicine may affect being able to get pregnant. This effect goes back to normal when the drug is stopped. If you have questions, talk with the doctor.
- Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using Invega Trinza (paliperidone injection) while you are pregnant.
- Taking Invega Trinza (paliperidone injection) in the third trimester of pregnancy may lead to muscle movements that cannot be controlled and withdrawal in the newborn. Talk with the doctor.
- Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.
How is this medicine (Invega Trinza) best taken?
Use Invega Trinza (paliperidone injection) as ordered by your doctor. Read all information given to you. Follow all instructions closely.
- It is given as a shot into a muscle.
- Drink lots of noncaffeine liquids unless told to drink less liquid by your doctor.
- Be careful in hot weather or while being active. Drink lots of fluids to stop fluid loss.
- It may take several weeks to see the full effects.
- Talk with your doctor before you use other drugs and natural products that slow your actions.
What do I do if I miss a dose?
- Call your doctor to find out what to do.
What are some side effects that I need to call my doctor about right away?
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Signs of high blood sugar like confusion, feeling sleepy, more thirst, more hungry, passing urine more often, flushing, fast breathing, or breath that smells like fruit.
- Very bad dizziness or passing out.
- Change in how you act.
- Mood changes.
- Shakiness, trouble moving around, or stiffness.
- Slow heartbeat.
- Trouble swallowing.
- More saliva.
- Any unexplained bruising or bleeding.
- Not able to control eye movements.
- Not sweating during activities or in warm temperatures.
- Very bad irritation where the shot was given.
- Sex problems like lowered interest in sex or ejaculation problems.
- Breast pain.
- Enlarged breasts.
- Nipple discharge.
- For women, no period.
- Call your doctor right away if you have a painful erection (hard penis) or an erection that lasts for longer than 4 hours. This may happen even when you are not having sex. If this is not treated right away, it may lead to lasting sex problems and you may not be able to have sex.
- A very bad and sometimes deadly health problem called neuroleptic malignant syndrome (NMS) may happen. Call your doctor right away if you have any fever, muscle cramps or stiffness, dizziness, very bad headache, confusion, change in thinking, fast heartbeat, heartbeat that does not feel normal, or are sweating a lot.
- A type of abnormal heartbeat (prolonged QT interval) can happen with Invega Trinza (paliperidone injection). Call your doctor right away if you have a fast heartbeat, a heartbeat that does not feel normal, or if you pass out.
What are some other side effects of Invega Trinza?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
- Weight gain.
- Feeling sleepy.
- Upset stomach or throwing up.
- Nose and throat irritation.
- Feeling tired or weak.
- Irritation where the shot is given.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.
If OVERDOSE is suspected:
If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
How do I store and/or throw out Invega Trinza?
- If you need to store Invega Trinza (paliperidone injection) at home, talk with your doctor, nurse, or pharmacist about how to store it.
Consumer information use
- If your symptoms or health problems do not get better or if they become worse, call your doctor.
- Do not share your drugs with others and do not take anyone else's drugs.
- Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
- Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
- Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
- Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
- Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about Invega Trinza (paliperidone injection), please talk with your doctor, nurse, pharmacist, or other health care provider.
- If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
More about Invega Trinza (paliperidone)
- Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Interactions
- Pricing & Coupons
- En Español
- 12 Reviews
- Drug class: atypical antipsychotics
- FDA Alerts (3)