Generic Name: lubiprostone (LOO-bi-PROS-tone)
Brand Name: Amitiza
Amitiza is used for:
Treating chronic constipation and constipation caused by opioid medicines in certain patients. It is also used to treat irritable bowel syndrome with constipation (IBS-C) in women. It may also be used for other conditions as determined by your doctor.
Amitiza is a chloride channel activator. It works by increasing fluid secretion in the intestine, which increases intestinal muscle movement and helps you to pass the stool.
Do NOT use Amitiza if:
- you are allergic to any ingredient in Amitiza
- you have severe diarrhea or stomach or bowel blockage
Contact your doctor or health care provider right away if any of these apply to you.
Before using Amitiza:
Some medical conditions may interact with Amitiza. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have diarrhea or a history of stomach or bowel blockage
- if you have liver problems
Some MEDICINES MAY INTERACT with Amitiza. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Methadone because it may decrease Amitiza's effectiveness
This may not be a complete list of all interactions that may occur. Ask your health care provider if Amitiza may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use Amitiza:
Use Amitiza as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Take Amitiza by mouth with food.
- Take Amitiza with a full glass (8 oz [240 mL]) of water.
- Swallow Amitiza whole. Do not break, crush, or chew before swallowing.
- If you miss a dose of Amitiza, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Amitiza.
Important safety information:
- Amitiza may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Amitiza with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
- Amitiza should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
- PREGNANCY and BREAST-FEEDING: If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Amitiza while you are pregnant. It is not known if this medicine is found in breast milk. If you are or will be breast-feeding while you use Amitiza, check with your doctor. It may cause diarrhea in breast-fed infants. Discuss any possible risks to your baby.
Possible side effects of Amitiza:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Diarrhea; gas; headache; nausea; stomach pain or bloating; tiredness; vomiting.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest or throat; swelling of the mouth, face, lips, or tongue); chest pain or discomfort; depression; fainting; increased, decreased, or painful urination; fast or irregular heartbeat; joint swelling; muscle pain, cramps, or spasms; severe or persistent diarrhea or nausea; shortness of breath; swelling of the hands or feet; tremor.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center ( http://www.aapcc.org), or emergency room immediately. Symptoms may include chest discomfort; dry mouth; excessive sweating; fainting; flushing; loss of appetite; pale skin; severe or persistent diarrhea, nausea, vomiting, or stomach pain or discomfort; severe or persistent dizziness or headache; shortness of breath; weakness.Proper storage of Amitiza:
Store Amitiza at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Amitiza out of the reach of children and away from pets.
- If you have any questions about Amitiza, please talk with your doctor, pharmacist, or other health care provider.
- Amitiza is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information should not be used to decide whether or not to take Amitiza or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Amitiza. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Amitiza. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Amitiza.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.
More about Amitiza (lubiprostone)
- Side Effects
- During Pregnancy
- Dosage Information
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- Drug Interactions
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- Drug class: chloride channel activators