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Accupril

Generic Name: quinapril (KWIN a pril)
Brand Names: Accupril

What is Accupril?

Accupril (quinapril) is an ACE inhibitor. ACE stands for angiotensin converting enzyme.

Accupril is used to treat high blood pressure (hypertension) and heart failure.

Accupril may also be used for purposes not listed in this medication guide.

Important information

Do not use Accupril if you are pregnant. If you become pregnant, stop taking this medicine and tell your doctor right away.

You should not use quinaprilif you have ever had angioedema. Do not take Accupril within 36 hours before or after taking medicine that contains sacubatril (such as Entresto).

If you have diabetes, do not use Accupril together with any medication that contains aliskiren (such as Tekturna or Tekamlo).

Before taking this medicine

You should not use Accupril if you are allergic to quinapril, or if:

  • you have a history of angioedema;

  • you recently took a heart medicine called sacubatril; or

  • if you are allergic to any other ACE inhibitor, such as benazepril, captopril, enalapril, fosinopril, lisinopril, moexipril, perindopril, ramipril, or trandolapril.

Do not take Accupril within 36 hours before or after taking medicine that contains sacubatril (such as Entresto).

If you have diabetes, do not use Accupril together with any medication that contains aliskiren (such as Tekturna or Tekamlo).

You may also need to avoid taking quinapril with aliskiren if you have kidney disease.

To make sure Accupril is safe for you, tell your doctor if you have ever had:

  • kidney disease (or if you are on dialysis);

  • liver disease;

  • a connective tissue disease such as Marfan syndrome, Sjogren's syndrome, lupus, scleroderma, or rheumatoid arthritis;

  • heart disease or congestive heart failure (unless you are taking quinapril for this condition); or

  • if you are on a low-salt diet.

Do not use if you are pregnant. If you become pregnant, stop taking this medicine and tell your doctor right away. Accupril can cause injury or death to the unborn baby if you take the medicine during your second or third trimester.

Quinapril can pass into breast milk and may harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

How should I take Accupril?

Take Accupril exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Your blood pressure will need to be checked often. Your kidney or liver function may also need to be tested.

Call your doctor if you have ongoing vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while taking Accupril. This can lead to very low blood pressure, electrolyte disorders, or kidney failure.

If you need surgery, tell the surgeon ahead of time that you are using Accupril. You may need to stop using the medicine for a short time.

If you are being treated for high blood pressure, keep using this medicine even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medicine for the rest of your life.

Store at room temperature away from moisture, heat, and light.

Accupril dosing information

Usual Adult Dose for Hypertension:

Initial dose: 10 or 20 mg orally once a day in patients not on diuretics
Maintenance dose: 20 to 80 mg orally per day, administered as a single dose or in two equally divided doses

Use:
-Treatment of hypertension

Usual Adult Dose for Congestive Heart Failure:

Initial dose: 5 mg orally twice a day
Maintenance dose: 20 to 40 mg orally per day administered in two equally divided doses

Comments:
-This dose may improve symptoms of heart failure, but increases in exercise duration have generally required higher doses.
-If the initial dosage is well tolerated, patients should then be titrated at weekly intervals until an effective dose.

Use:
-Management of heart failure as adjunctive therapy when added to conventional therapy including diuretics and/or digitalis

Usual Geriatric Dose for Congestive Heart Failure:

10 mg orally once a day

Comments: Dose should be titrated the same way as for other adult patients.

Uses:
-Treatment of hypertension
-Management of heart failure as adjunctive therapy when added to conventional therapy including diuretics and/or digitalis

Usual Geriatric Dose for Hypertension:

10 mg orally once a day

Comments: Dose should be titrated the same way as for other adult patients.

Uses:
-Treatment of hypertension
-Management of heart failure as adjunctive therapy when added to conventional therapy including diuretics and/or digitalis

See also: Dosage Information (in more detail)

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking Accupril?

Do not use salt substitutes or potassium supplements while taking Accupril, unless your doctor has told you to.

Drinking alcohol can further lower your blood pressure and may increase certain side effects of quinapril.

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

Accupril side effects

Get emergency medical help if you have signs of an allergic reaction to Accupril: hives; severe stomach pain; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • a light-headed feeling, like you might pass out;

  • fast or pounding heartbeats, fluttering in your chest;

  • little or no urination;

  • pain or burning when you urinate;

  • jaundice (yellowing of the skin or eyes);

  • numbness, tingling, or burning pain in your hands or feet;

  • fever, chills, cold or flu symptoms;

  • high potassium - nausea, slow or unusual heart rate, weakness, loss of movement; or

  • low sodium - headache, confusion, slurred speech, severe weakness, vomiting, loss of coordination, feeling unsteady.

Common Accupril side effects may include:

  • headache;

  • cough; or

  • dizziness, tired feeling.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect Accupril?

Tell your doctor about all your current medicines and any you start or stop using, especially:

  • lithium;

  • a diuretic or "water pill";

  • gold injections to treat arthritis; or

  • NSAIDs (nonsteroidal anti-inflammatory drugs) - aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others.

This list is not complete. Other drugs may interact with quinapril, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Where can I get more information?

  • Your pharmacist can provide more information about Accupril.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Accupril only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2018 Cerner Multum, Inc. Version: 13.02.

Last reviewed: September 29, 2017
Date modified: November 06, 2017

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