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Accupril Side Effects

Generic Name: quinapril

Note: This document contains side effect information about quinapril. Some of the dosage forms listed on this page may not apply to the brand name Accupril.

For the Consumer

Applies to quinapril: oral tablet

Along with its needed effects, quinapril (the active ingredient contained in Accupril) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking quinapril:

Less Common

  • Blurred vision
  • chest pain
  • confusion
  • diarrhea
  • difficult or labored breathing
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • nausea
  • stomach pain
  • sweating
  • tightness in the chest
  • unusual tiredness or weakness
  • vomiting

Rare

  • Bleeding gums
  • cold, clammy skin
  • enlarged pupils
  • fast or slow heartbeat
  • increased sensitivity of the skin or eyes to sunlight
  • stiff or sore neck

Some side effects of quinapril may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More Common

Less Common

  • Back pain
  • coughing
  • difficulty with moving
  • joint pain
  • muscle aching or cramping
  • muscle pains or stiffness
  • rash
  • swollen joints

For Healthcare Professionals

Applies to quinapril: oral tablet

General

The most commonly reported side effects were dizziness, increased serum creatinine, increased blood urea nitrogen, cough, dyspnea, nausea, vomiting, and diarrhea.[Ref]

Cardiovascular

Uncommon (0.1% to 1%): Chest pain, hypotension, palpitations, vasodilation, tachycardia, heart failure, myocardial infarction, hypertensive crisis, angina pectoris, orthostatic hypotension, cardiac rhythm disturbances, cardiogenic shock[Ref]

Renal

Common (1% to 10%): Increased serum creatinine, increased blood urea nitrogen

Uncommon (0.1% to 1%): Urinary tract infection, acute renal failure/dysfunction, worsening renal failure, proteinuria

Frequency not reported: Increases in blood urea nitrogen and serum creatinine[Ref]

Metabolic

Uncommon (0.1% to 1%): Hyperkalemia, hyponatremia[Ref]

Hematologic

Uncommon (0.1% to 1%): Hemolytic anemia, agranulocytosis, thrombocytopenia

Frequency not reported: Neutropenia, decreased hemoglobin, decreased hematocrit[Ref]

Hypersensitivity

Uncommon (0.1% to 1%): Angioedema of the head, neck, face, extremities, lips, tongue, glottis and/or larynx, intestines; anaphylactoid reactions[Ref]

Hepatic

Uncommon (0.1% to 1%): Abnormal liver function tests, hepatitis

Rare (less than 0.1%): Hepatic failure (characterized by cholestatic jaundice with progression to fulminant hepatic necrosis and sometimes death)

Frequency not reported: Cholestatic icterus[Ref]

Nervous system

Common (1% to 10%): Dizziness

Uncommon (0.1% to 1%): Headache, cerebrovascular accident/cerebral hemorrhage, somnolence, vertigo, syncope, nervousness, paresthesia, transient ischemic attacks, tinnitus

Rare (less than 0.1%): Balance disorder[Ref]

Gastrointestinal

Common (1% to 10%): Nausea, vomiting, diarrhea, dyspepsia, abdominal pain

Uncommon (0.1% to 1%): Flatulence, dry mouth or throat, constipation, gastrointestinal hemorrhage, pancreatitis

Rare (less than 0.1%): Glossitis

Very rare (less than 0.01%): Ileus[Ref]

Respiratory

Common (1% to 10%): Cough, pharyngitis, dyspnea, rhinitis

Uncommon (0.1% to 1%): Eosinophilic pneumonitis, sinusitis, upper respiratory tract infection, bronchitis

Frequency not reported: Bronchospasm[Ref]

Musculoskeletal

Uncommon (0.1% to 1%): Myalgia, back pain, arthralgia

Genitourinary

Uncommon (0.1% to 1%): Impotence[Ref]

Psychiatric

Uncommon (0.1% to 1%): Depression, insomnia, confusion[Ref]

Other

Common (1% to 10%): Fatigue, asthenia

Uncommon (0.1% to 1%): Fever, malaise, generalized/peripheral edema[Ref]

Immunologic

Uncommon (0.1% to 1%): Viral infection[Ref]

Dermatologic

Uncommon (0.1% to 1%): Rash, alopecia, increased sweating, pemphigus, pruritus, exfoliative dermatitis, photosensitivity reaction, dermatopolymyositis

Rare (less than 0.1%): Urticaria, erythema multiforme, pemphigus

Very rare (less than 0.01%): Psoriasis-like efflorescence

Frequency not reported: Stevens Johnson syndrome, epidermal necrolysis[Ref]

Ocular

Uncommon (0.1% to 1): Amblyopia

Very rare (less than 0.01%): Blurred vision[Ref]

References

1. "Product Information. Accupril (quinapril)." Parke-Davis, Morris Plains, NJ.

2. Cerner Multum, Inc. "Australian Product Information." O 0

3. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

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