Accupril Side Effects

Generic name: quinapril

Medically reviewed by Drugs.com. Last updated on Feb 4, 2025.

Note: This document provides detailed information about Accupril Side Effects associated with quinapril. Some dosage forms listed on this page may not apply specifically to the brand name Accupril.

Applies to quinapril: oral tablet.

Precautions

It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly. Blood tests may be needed to check for unwanted effects.

Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using this medicine, tell your doctor right away.

You should not use this medicine together with sacubitril. Do not use this medicine and sacubitril/valsartan (Entresto®) within 36 hours of each other.

This medicine may cause a serious type of allergic reaction called anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash, itching, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, mouth, or throat while you are using this medicine.

Call your doctor right away if you have severe stomach pain (with or without nausea or vomiting). This could be a symptom of a condition called intestinal angioedema.

Dizziness, lightheadedness, or fainting may also occur, especially when you get up from a lying or sitting position or if you have been taking a diuretic (water pill). Make sure you know how you react to the medicine before you drive, use machines, or do other things that could be dangerous if you are dizzy or not alert. If you feel dizzy, lie down so you do not faint. Then sit for a few moments before standing to prevent the dizziness from returning.

Check with your doctor right away if you have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, unusual tiredness or weakness, or yellow eyes or skin. These could be symptoms of a serious liver problem.

Check with your doctor right away if you have lower back or side pain, decreased frequency or amount of urine, bloody urine, increased thirst, swelling of the face, fingers, or lower legs, weight gain, or increased blood pressure. These could be symptoms of a serious kidney problem.

Check with your doctor if you have a fever, chills, or sore throat. These may be symptoms of an infection resulting from low white blood cells.

Hyperkalemia (high potassium in the blood) may occur while you are using this medicine. Check with your doctor right away if you have the following symptoms: abdominal or stomach pain, confusion, difficulty with breathing, irregular heartbeat, nausea or vomiting, nervousness, numbness or tingling in the hands, feet, or lips, shortness of breath, or weakness or heaviness of the legs. Ask your doctor before you use any medicine, supplement, or salt substitute that contains potassium..

Make sure any doctor or dentist who treats you knows that you are using this medicine. You may need to stop using this medicine several days before having surgery or medical tests.

This medicine may be less effective in black patients. Black patients also have an increased risk of swelling of the hands, arms, face, mouth, or throat. Talk with your doctor if you have concerns about this.

Do not take other medicines unless they have been discussed with your doctor. This especially includes over-the-counter (nonprescription) medicines for appetite control, asthma, colds, cough, hay fever, or sinus problems, since they may tend to increase your blood pressure.

Common side effects of Accupril

Some side effects of quinapril may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Serious side effects of Accupril

Along with its needed effects, quinapril (the active ingredient contained in Accupril) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking quinapril:

For healthcare professionals

Applies to quinapril: oral tablet.

General adverse events

The most commonly reported side effects were dizziness, increased serum creatinine, increased blood urea nitrogen, cough, dyspnea, nausea, vomiting, and diarrhea.^[Ref]

Cardiovascular

• Uncommon (0.1% to 1%): Chest pain, hypotension, palpitations, vasodilation, tachycardia, heart failure, myocardial infarction, hypertensive crisis, angina pectoris, orthostatic hypotension, cardiac rhythm disturbances, cardiogenic shock^[Ref]

Renal

• Common (1% to 10%): Increased serum creatinine, increased blood urea nitrogen
• Uncommon (0.1% to 1%): Urinary tract infection, acute renal failure/dysfunction, worsening renal failure, proteinuria
• Frequency not reported: Increases in blood urea nitrogen and serum creatinine^[Ref]

Metabolic

• Uncommon (0.1% to 1%): Hyperkalemia, hyponatremia^[Ref]

Hematologic

• Uncommon (0.1% to 1%): Hemolytic anemia, agranulocytosis, thrombocytopenia
• Frequency not reported: Neutropenia, decreased hemoglobin, decreased hematocrit^[Ref]

Hypersensitivity

• Uncommon (0.1% to 1%): Angioedema of the head, neck, face, extremities, lips, tongue, glottis and/or larynx, intestines; anaphylactoid reactions^[Ref]

Hepatic

• Uncommon (0.1% to 1%): Abnormal liver function tests, hepatitis
• Rare (less than 0.1%): Hepatic failure (characterized by cholestatic jaundice with progression to fulminant hepatic necrosis and sometimes death)
• Frequency not reported: Cholestatic icterus^[Ref]

Nervous system

• Common (1% to 10%): Dizziness
• Uncommon (0.1% to 1%): Headache, cerebrovascular accident/cerebral hemorrhage, somnolence, vertigo, syncope, nervousness, paresthesia, transient ischemic attacks, tinnitus
• Rare (less than 0.1%): Balance disorder^[Ref]

Gastrointestinal

• Common (1% to 10%): Nausea, vomiting, diarrhea, dyspepsia, abdominal pain
• Uncommon (0.1% to 1%): Flatulence, dry mouth or throat, constipation, gastrointestinal hemorrhage, pancreatitis
• Rare (less than 0.1%): Glossitis
• Very rare (less than 0.01%): Ileus^[Ref]

Respiratory

• Common (1% to 10%): Cough, pharyngitis, dyspnea, rhinitis
• Uncommon (0.1% to 1%): Eosinophilic pneumonitis, sinusitis, upper respiratory tract infection, bronchitis
• Frequency not reported: Bronchospasm^[Ref]

Musculoskeletal

• Uncommon (0.1% to 1%): Myalgia, back pain, arthralgia

Genitourinary

• Uncommon (0.1% to 1%): Impotence^[Ref]

Psychiatric

• Uncommon (0.1% to 1%): Depression, insomnia, confusion^[Ref]

Other

• Common (1% to 10%): Fatigue, asthenia
• Uncommon (0.1% to 1%): Fever, malaise, generalized/peripheral edema^[Ref]

Immunologic

• Uncommon (0.1% to 1%): Viral infection^[Ref]

Dermatologic

• Uncommon (0.1% to 1%): Rash, alopecia, increased sweating, pemphigus, pruritus, exfoliative dermatitis, photosensitivity reaction, dermatopolymyositis
• Rare (less than 0.1%): Urticaria, erythema multiforme, pemphigus
• Very rare (less than 0.01%): Psoriasis-like efflorescence
• Frequency not reported: Stevens Johnson syndrome, epidermal necrolysis^[Ref]

Ocular

• Uncommon (0.1% to 1): Amblyopia
• Very rare (less than 0.01%): Blurred vision^[Ref]

See also:

Frequently asked questions

• Do ACE inhibitors make COVID-19 worse?

Further information

Accupril side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer