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Quinapril Pregnancy and Breastfeeding Warnings

Brand names: Accupril

Medically reviewed by Drugs.com. Last updated on Jun 11, 2025.

Quinapril Pregnancy Warnings

Use is not recommended during the first trimester of pregnancy. Use is contraindicated during the second and third trimesters of pregnancy.

AU TGA pregnancy category: D
US FDA pregnancy category: Not assigned

Risk summary: No data are available on the use of this drug in pregnant women to inform a drug-related risk.

Comments: Appropriate management of maternal hypertension during pregnancy is important to optimize outcomes for both mother and fetus.

Animal studies have revealed no evidence of teratogenicity. There are no controlled data in human pregnancy. Use of drugs that act on the renin-angiotensin system (RAS) during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death. Oligohydramnios can be associated with fetal lung hypoplasia and skeletal deformations. Potential neonatal adverse effects include skull hypoplasia, anuria, hypotension, renal failure, and death.

AU TGA pregnancy category D: Drugs which have caused, are suspected to have caused or may be expected to cause, an increased incidence of human fetal malformations or irreversible damage. These drugs may also have adverse pharmacological effects. Accompanying texts should be consulted for further details.

US FDA pregnancy category Not Assigned: The US FDA has amended the pregnancy labeling rule for prescription drug products to require labeling that includes a summary of risk, a discussion of the data supporting that summary, and relevant information to help health care providers make prescribing decisions and counsel women about the use of drugs during pregnancy. Pregnancy categories A, B, C, D, and X are being phased out.

See references

Quinapril Breastfeeding Warnings

Use is not recommended.

Excreted into human milk: Yes

Comments: The effects in the nursing infant are unknown.

See references

Does Quinapril interact with my other drugs?

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See also

References for pregnancy information

  1. (2001) "Product Information. Accupril (quinapril)." Parke-Davis
  2. Cerner Multum, Inc. "UK Summary of Product Characteristics."
  3. Cerner Multum, Inc. "Australian Product Information."
  4. (2023) "Product Information. Accupril (quinapril)." PD-RX Pharmaceuticals

References for breastfeeding information

  1. (2001) "Product Information. Accupril (quinapril)." Parke-Davis
  2. Cerner Multum, Inc. "UK Summary of Product Characteristics."
  3. Cerner Multum, Inc. "Australian Product Information."

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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