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Yosprala

Generic Name: aspirin and omeprazole (AS pir in and oh MEP ra zole)
Brand Names: Yosprala

Medically reviewed on May 16, 2018

What is Yosprala?

Yosprala contains a combination of aspirin and omeprazole. Aspirin is a salicylate. It works by reducing substances in the body that cause pain, fever, and inflammation. Omeprazole is a proton pump inhibitor. It decreases the amount of acid produced in the stomach.

Yosprala is a platelet aggregation inhibitor and is used to help lower the risk of heart problems, strokes, or death in people who have had certain conditions related to blood clots, including angina (chest pain), a past heart attack, or a stroke or a "mini stroke."

Yosprala is also used in people who have had surgery to improve blood flow to the heart and also have another condition that is already being treated with aspirin.

The omeprazole in this combination medicine helps reduce the risk of stomach ulcers that may be caused by aspirin, especially in people who are 55 or older, or those who have had stomach ulcers in the past.

Important Information

You should not use Yosprala if you have severe breathing problems, sinus problems, or nasal polyps, if you take medicine that contains rilpivirine, or if you've had an asthma attack or severe allergic reaction to aspirin or an NSAID (nonsteroidal anti-inflammatory drug).

Yosprala can cause serious side effects. Call your doctor if you cough up blood or if you have bloody or tarry stools, unusual bleeding or bruising, decreased urination, joint pain and a rash on your face and arms, or sudden pain in your wrist, thigh, hip, or back.

Before taking this medicine

You should not use Yosprala if you are allergic to aspirin or omeprazole, or if:

  • you have severe breathing problems, asthma, sinus problems, or nasal polyps (growths inside your nose);

  • you take medicine that contains rilpivirine (Edurant, Complera, Juluca, Odefsey); or

  • you've had an asthma attack or severe allergic reaction after taking aspirin or an NSAID (nonsteroidal anti-inflammatory drug).

Yosprala is not approved for use by anyone younger than 18 years old. Aspirin can cause Reye syndrome, a serious and sometimes fatal condition in children.

Yosprala should not be used to treat a sudden onset of heart attack or stroke symptoms (chest pain, sudden numbness or weakness, slurred speech).

Tell your doctor if you have ever had:

Taking Yosprala may increase your risk of bone fracture in the hip, wrist, or spine. Your risk is highest if you take the medicine long term or at high doses, and if you are age 50 or older.

Taking aspirin during late pregnancy may cause bleeding in the mother or the baby during delivery. Tell your doctor if you are pregnant or plan to become pregnant.

Yosprala may temporarily affect your ability to get pregnant. Talk with your doctor if this concerns you.

You should not breast-feed while using Yosprala.

How should I take Yosprala?

Take Yosprala exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the lowest dose that is effective in treating your condition.

Take this medicine with a full glass of water. The usual dose is once daily, 1 hour before a meal.

Swallow the tablet whole and do not crush, chew, or break it.

Yosprala can affect the results of certain medical tests. Tell any doctor who treats you that you are using aspirin and omeprazole.

Omeprazole may affect a drug-screening urine test and you could have false results. Tell the laboratory staff that you use aspirin and omeprazole.

Do not stop using this medicine suddenly, even if you feel fine. Stopping suddenly may increase your risk of heart attack or stroke. Follow your doctor's instructions about tapering your dose.

If you use Yosprala for longer than 3 years, you could develop a vitamin B-12 deficiency. Talk to your doctor about how to manage this condition if you develop it.

Store at room temperature away from moisture and heat. Keep the tablets in their original container, along with the packet or canister of moisture-absorbing preservative.

Yosprala dosing information

Usual Adult Dose of Yosprala for Thromboembolic Stroke Prophylaxis:

One tablet (aspirin 81 mg-omeprazole 40 mg or aspirin 325 mg-omeprazole 40 mg) orally once a day at least 60 minutes before a meal

Comments:
-Generally, 81 mg of aspirin has been accepted as an effective dose for secondary cardiovascular prevention; the current clinical practice guidelines should be referenced when considering the need for 325 mg of aspirin.

Use: For patients requiring secondary prevention of cardiovascular and cerebrovascular events who are at risk of developing aspirin associated gastric ulcers.

Usual Adult Dose of Yosprala for Ischemic Stroke -- Prophylaxis:

One tablet (aspirin 81 mg-omeprazole 40 mg or aspirin 325 mg-omeprazole 40 mg) orally once a day at least 60 minutes before a meal

Comments:
-Generally, 81 mg of aspirin has been accepted as an effective dose for secondary cardiovascular prevention; the current clinical practice guidelines should be referenced when considering the need for 325 mg of aspirin.

Use: For patients requiring secondary prevention of cardiovascular and cerebrovascular events who are at risk of developing aspirin associated gastric ulcers.

Usual Adult Dose of Yosprala for Cardiovascular Risk Reduction:

One tablet (aspirin 81 mg-omeprazole 40 mg or aspirin 325 mg-omeprazole 40 mg) orally once a day at least 60 minutes before a meal

Comments:
-Generally, 81 mg of aspirin has been accepted as an effective dose for secondary cardiovascular prevention; the current clinical practice guidelines should be referenced when considering the need for 325 mg of aspirin.

Use: For patients requiring secondary prevention of cardiovascular and cerebrovascular events who are at risk of developing aspirin associated gastric ulcers.

Usual Adult Dose of Yosprala for Gastric Ulcer Prophylaxis:

One tablet (aspirin 81 mg-omeprazole 40 mg or aspirin 325 mg-omeprazole 40 mg) orally once a day at least 60 minutes before a meal

Comments:
-Generally, 81 mg of aspirin has been accepted as an effective dose for secondary cardiovascular prevention; the current clinical practice guidelines should be referenced when considering the need for 325 mg of aspirin.

Use: For patients requiring secondary prevention of cardiovascular and cerebrovascular events who are at risk of developing aspirin associated gastric ulcers.

See also: Dosage Information (in more detail)

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include ringing in your ears, increased thirst, muscle pain or weakness, trouble breathing, or feeling cold.

What should I avoid while taking Yosprala?

Ask a doctor or pharmacist before using over-the-counter medicines. They may contain ingredients similar to aspirin or omeprazole.

Taking regular aspirin together with omeprazole (Prilosec) will not work the same way as taking Yosprala. Do not substitute this medicine with over-the-counter products.

Drinking alcohol can increase your risk of stomach bleeding.

Yosprala side effects

Get emergency medical help if you have signs of an allergic reaction to Yosprala: sneezing, runny or stuffy nose; wheezing or trouble breathing; hives; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • severe nausea, vomiting, stomach pain, or diarrhea that is watery or bloody;

  • bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;

  • easy bruising, unusual bleeding (such as a nosebleed), or any bleeding that will not stop;

  • sudden pain or trouble moving your hip, wrist, or back;

  • kidney problems - urinating less than usual, blood in your urine, swelling, skin rash, unusual breath odor;

  • liver problems - stomach pain, itching, dark urine, jaundice (yellowing of the skin or eyes);

  • lupus-like syndrome - joint pain or swelling, skin rash on your face or arms that worsens in sunlight;

  • symptoms of low vitamin B-12 levels - pale skin, tingling or numbness, muscle weakness, feeling light-headed or short of breath, tiredness, mood changes; or

  • symptoms of low magnesium - dizziness, irregular heartbeats, feeling jittery, muscle cramps, muscle spasms in your hands and feet, cough or choking feeling.

Common Yosprala side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect Yosprala?

Tell your doctor about all your other medicines, especially:

This list is not complete. Other drugs may with interact with aspirin and omeprazole, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Yosprala only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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