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Amlodipine and atorvastatin

Generic Name: amlodipine and atorvastatin (am LOE di peen and a TOR va sta tin)
Brand Name: Caduet

Medically reviewed on Jul 31, 2018

What is amlodipine and atorvastatin?

Atorvastatin is in a group of drugs called HMG CoA reductase inhibitors, or "statins." Atorvastatin reduces levels of "bad" cholesterol (low-density lipoprotein, or LDL) and triglycerides in the blood, while increasing levels of "good" cholesterol (high-density lipoprotein, or HDL).

Amlodipine is a calcium channel blocker. Amlodipine relaxes the blood vessels, improving blood flow and making it easier for the heart to pump.

Amlodipine and atorvastatin is a combination medicine used to treat high blood pressure (hypertension) or chest pain (angina), and to lower the risk of stroke, heart attack, and other heart complications in people with type 2 diabetes, coronary heart disease, or other risk factors.

Amlodipine and atorvastatin is used in adults and children who are at least 10 years old.

Amlodipine and atorvastatin may also be used for purposes not listed in this medication guide.

Important Information

You should not use amlodipine and atorvastatin if you have liver disease.

Amlodipine and atorvastatin can harm an unborn baby or cause birth defects. Do not use if you are pregnant. If you become pregnant, stop taking this medicine and tell your doctor right away.

Do not breast-feed while taking amlodipine and atorvastatin.

Before taking this medicine

You should not use this medicine if you are allergic to amlodipine (Norvasc) or atorvastatin (Lipitor), or if:

  • you have liver disease; or

  • you are pregnant or breast-feeding.

Do not use amlodipine and atorvastatin if you are pregnant. It could harm the unborn baby or cause birth defects. Use effective birth control to prevent pregnancy while you are using this medicine. If you become pregnancy, stop taking this medicine and tell your doctor right away.

Do not breast-feed while taking amlodipine and atorvastatin.

Tell your doctor if you have ever had:

  • kidney disease;

  • heart disease;

  • muscle pain or weakness;

  • diabetes;

  • a thyroid disorder; or

  • if you drink more than 2 alcoholic beverages daily.

Atorvastatin can cause the breakdown of muscle tissue, which can lead to kidney failure. This happens more often in women, in older adults, or people who have kidney disease or poorly controlled hypothyroidism (underactive thyroid).

Certain other drugs can increase your risk of serious muscle problems when used with amlodipine and atorvastatin. Your doctor may need to change your treatment plan if you use any of the following drugs:

How should I take amlodipine and atorvastatin?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Take amlodipine and atorvastatin at the same time each day, with or without food.

Do not break an amlodipine and atorvastatin tablet. Tell your doctor if you have trouble swallowing the pill.

You may need to stop using amlodipine and atorvastatin for a short time if you have:

  • uncontrolled seizures;

  • an electrolyte imbalance (such as high or low potassium levels in your blood);

  • severely low blood pressure;

  • a severe infection or illness; or

  • surgery or a medical emergency.

You will need frequent medical tests.

You may need to take amlodipine and atorvastatin on a long-term basis. Keep using this medication even if you feel fine. High blood pressure or high cholesterol often have no symptoms.

Amlodipine and atorvastatin is only part of a complete program of treatment that also includes diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Use the medicine as soon as you can, but skip the missed dose if your next dose is due in less than 12 hours. Do not use two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking amlodipine and atorvastatin?

Avoid eating foods high in fat or cholesterol, or amlodipine and atorvastatin will not be as effective.

Avoid drinking alcohol. It can raise triglyceride levels and increase your risk of liver damage. Alcohol can also increase some of the side effects of amlodipine and atorvastatin.

Grapefruit may interact with this medicine and lead to unwanted side effects. Avoid the use of grapefruit products.

Amlodipine and atorvastatin side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

In rare cases, atorvastatin can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, or dark colored urine.

Stop using amlodipine and atorvastatin and call your doctor at once if you have:

  • muscle stiffness, tremors, abnormal muscle movements;

  • severe drowsiness, feeling like you might pass out;

  • worsening chest pain, or chest pain spreading to the arm or jaw, nausea, sweating, general ill feeling; or

  • liver problems--nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect amlodipine and atorvastatin?

Certain other drugs can increase your risk of serious muscle problems, and it is very important that your doctor knows if you are using any of them. Tell your doctor about all your other medicines, especially:

  • antibiotic or antifungal medicine;

  • birth control pills;

  • cholesterol-lowering medication;

  • heart medication; or

  • medicine to treat HIV or AIDS.

This list is not complete. Other drugs may affect amlodipine and atorvastatin, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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