Amlodipine / Atorvastatin Side Effects

Medically reviewed by Drugs.com. Last updated on Dec 6, 2023.

Applies to amlodipine / atorvastatin: oral tablet.

Serious side effects

Along with its needed effects, amlodipine/atorvastatin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking amlodipine / atorvastatin:

More common side effects

• cough
• difficulty with swallowing
• dizziness
• fast heartbeat
• hives, itching, skin rash
• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• tightness in the chest
• unusual tiredness or weakness

Rare side effects

• chest pain or discomfort
• dilated neck veins
• extra heartbeats
• irregular breathing
• irregular heartbeat or pulse
• swelling of the face, fingers, feet, or lower legs
• weight gain

Incidence not known

• blistering, peeling, or loosening of the skin
• chills
• dark-colored urine
• diarrhea
• fever
• joint or muscle pain
• muscle cramps, spasms, or stiffness
• red, irritated eyes
• red skin lesions, often with a purple center
• sore throat
• sores, ulcers, or white spots in the mouth or on the lips

Get emergency help immediately if any of the following symptoms of overdose occur while taking amlodipine / atorvastatin:

Symptoms of overdose

• blurred vision
• confusion
• dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
• feeling of warmth
• redness of the face, neck, arms, and occasionally, upper chest
• sweating

Other side effects

Some side effects of amlodipine / atorvastatin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common side effects

• body aches or pain
• congestion
• difficulty with moving
• headache
• lower back or side pain
• pain or tenderness around the eyes and cheekbones
• painful or difficult urination
• runny or stuffy nose
• tender, swollen glands in the neck
• voice changes

Less common side effects

• accidental injury
• acid or sour stomach
• belching
• bloated or full feeling
• difficulty having a bowel movement (stool)
• excess air or gas in the stomach or intestines
• general feeling of discomfort or illness
• heartburn
• indigestion
• lack or loss of strength
• loss of appetite
• nausea
• passing gas
• shivering
• sleepiness or unusual drowsiness
• stomach discomfort, upset, or pain
• trouble sleeping
• vomiting

Rare side effects

• anxiety
• bad, unusual, or unpleasant (after) taste
• blistering, crusting, irritation, itching, or reddening of the skin
• burning feeling in the chest or stomach
• burning while urinating
• change in near or distance vision
• change in taste
• change in the color of the skin
• cold and clammy skin
• cracked, dry, scaly skin
• difficulty in focusing eyes
• dry mouth
• dryness of the eyes
• excessive muscle tone
• frequent urination
• hair loss or thinning of the hair
• increased appetite
• increased volume of pale, dilute urine
• irritability
• lack of feeling or emotion
• loose stools
• loss of memory
• muscle tension, tightness, or weakness
• problems with memory
• restlessness
• severe and throbbing headache
• shakiness and unsteady walk
• sneezing
• tenderness in the stomach area
• transient, mild, or pleasant aromatic odor
• trembling, or other problems with muscle control or coordination
• twitching
• uncaring
• unsteadiness
• welts

For healthcare professionals

Applies to amlodipine / atorvastatin: oral tablet.

General adverse events

The most common side effect of amlodipine was edema. The most common side effects of atorvastatin were diarrhea, nasopharyngitis, and arthralgia.^[Ref]

Gastrointestinal

• Common (1% to 10%): Abdominal pain, constipation, diarrhea, dyspepsia, nausea
• Uncommon (0.1% to 1%): Flatulence

Amlodipine:

• Common (1% to 10%): Nausea, abdominal pain, constipation, dyspepsia
• Uncommon (0.1% to 1%): Dysphagia, diarrhea, flatulence, pancreatitis, vomiting, gingival hyperplasia, dry mouth, flatulence, altered bowel habits
• Frequency not reported: Gastritis, loose stools

Atorvastatin:

• Very common (10% or more): Diarrhea (up to 14.1%)
• Common (1% to 10%): Dyspepsia, nausea, abdominal pain, constipation, flatulence
• Uncommon (0.1% to 1%): Abdominal discomfort, vomiting
• Rare (less than 0.1%): Eructation^[Ref]

Respiratory

• Common (1% to 10%): Respiratory tract infection
• Uncommon (0.1% to 1%): Pharyngitis, rhinitis

Amlodipine:

• Common (1% to 10%): Epistaxis, respiratory tract infection
• Uncommon (0.1% to 1%): Dyspnea, pharyngitis, rhinitis
• Frequency not reported: Coughing

Atorvastatin:

• Very common (10% or more): Nasopharyngitis (up to 12.9%)
• Common (1% to 10%): Pharyngolaryngeal pain, respiratory tract infection, rhinitis
• Uncommon (0.1% to 1%): Pharyngitis, asthma
• Rare (less than 0.1%): Sinusitis
• Frequency not reported: Epistaxis, interstitial lung disease^[Ref]

Musculoskeletal

• Common (1% to 10%): Back pain, arthralgia, myalgia
• Uncommon (0.1% to 1%): Leg cramps

Amlodipine:

• Common (1% to 10%): Back pain, myalgia, arthralgia
• Uncommon (0.1% to 1%): Arthrosis, muscle cramps, leg cramps
• Frequency not reported: Muscle weakness, twitching

Atorvastatin:

• Very common (10% or more): Arthralgia (up to 11.7%)
• Common (1% to 10%): Pain in extremity, musculoskeletal pain, muscle spasms, myalgia, back pain
• Uncommon (0.1% to 1%): Creatine kinase elevations 10 times the upper limit of normal or greater, leg cramps, neck pain
• Rare (less than 0.1%): Myositis, myopathy, muscle fatigue
• Frequency not reported: Joint swelling, blood creatine phosphokinase increased
• Postmarketing reports: Rhabdomyolysis, tendon rupture, immune-mediated necrotizing myopathy^[Ref]

Other

• Common (1% to 10%): Accidental injury, asthenia, pain
• Uncommon (0.1% to 1%): Vertigo

Amlodipine:

• Very common (10% or more): Edema (up to 10.8%)
• Common (1% to 10%): Fatigue, accidental injury, asthenia, pain
• Uncommon (0.1% to 1%): Vertigo, malaise, rigors, tinnitus, gynecomastia

Atorvastatin:

• Common (1% to 10%): Accidental injury, asthenia
• Uncommon (0.1% to 1%): Pain, vertigo, deafness, malaise
• Rare (less than 0.1%): Tinnitus, pyrexia
• Postmarketing reports: Fatigue, gynecomastia^[Ref]

Cardiovascular

• Common (1% to 10%): Palpitation, vasodilation, peripheral edema
• Uncommon (0.1% to 1%): Hypertension

Amlodipine:

• Common (1% to 10%): Flushing, palpitation, peripheral edema
• Uncommon (0.1% to 1%): Arrhythmia, bradycardia, chest pain, peripheral ischemia, tachycardia, vasculitis, hot flushes, vasodilation, hypotension, postural hypotension
• Frequency not reported: Cardiac failure, pulse irregularity, extrasystoles, myocardial infarction

Atorvastatin:

• Common (1% to 10%): Hypertension, palpitation
• Uncommon (0.1% to 1%): Vasodilation
• Postmarketing reports: Chest pain, peripheral edema^[Ref]

Hepatic

• Common (1% to 10%): GGT increased, ALT increased, AST increased

Amlodipine:

• Uncommon (0.1% to 1%): GGT increased, ALT increased, AST increased, pancreatitis
• Postmarketing reports: Jaundice, hepatic enzyme elevations, hepatitis

Atorvastatin:

• Common (1% to 10%): Transaminase elevations 3 times the upper limit of normal or greater twice within 4 to 10 days
• Uncommon (0.1% to 1%): GGT increased, ALT increased, AST increased
• Rare (less than 0.1%): Pancreatitis, hepatitis, cholestasis
• Frequency not reported: Transaminases increased, liver function test abnormal, blood alkaline phosphatase increased
• Postmarketing reports: Fatal and non-fatal hepatic failure^[Ref]

Nervous system

• Common (1% to 10%): Headache, dizziness
• Uncommon (0.1% to 1%): Paresthesia

Amlodipine:

• Common (1% to 10%): Dizziness, somnolence, headache
• Uncommon (0.1% to 1%): Syncope, hypoesthesia, neuropathy peripheral, paresthesia, tremor, postural dizziness
• Frequency not reported: Ataxia, hypertonia, migraine, amnesia, parosmia, taste perversion
• Postmarketing reports: Extrapyramidal disorder

Atorvastatin:

• Common (1% to 10%): Hemorrhagic stroke, headache, dizziness
• Uncommon (0.1% to 1%): Hypoesthesia, paresthesia
• Rare (less than 0.1%): Peripheral neuropathy
• Postmarketing reports: Cognitive impairment, amnesia, dysgeusia^[Ref]

Immunologic

• Common (1% to 10%): Flu syndrome
• Uncommon (0.1% to 1%): Allergic reaction

Amlodipine:

• Common (1% to 10%): Allergic reaction
• Uncommon (0.1% to 1%): Flu syndrome

Atorvastatin:

• Common (1% to 10%): Flu syndrome
• Uncommon (0.1% to 1%): Allergic reaction, infection, influenza
• Rare (less than 0.1%): Hypersensitivity, anaphylaxis^[Ref]

Dermatologic

• Common (1% to 10%): Rash

Amlodipine:

• Common (1% to 10%): Rash, rash erythematous
• Uncommon (0.1% to 1%): Angioedema, erythema multiforme, pruritus, rash maculopapular, sweating increased, purpura, alopecia
• Frequency not reported: Skin discoloration, urticaria, skin dryness, dermatitis, cold and clammy skin

Atorvastatin:

• Uncommon (0.1% to 1%): Rash, pruritus, urticaria
• Rare (less than 0.1%): Angioedema, alopecia
• Postmarketing reports: Angioneurotic edema, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis^[Ref]

Psychiatric

• Uncommon (0.1% to 1%): Depression, insomnia

Amlodipine:

• Uncommon (0.1% to 1%): Insomnia, nervousness, depression, abnormal dreams, anxiety, depersonalization, mood changes
• Frequency not reported: Apathy, agitation

Atorvastatin:

• Common (1% to 10%): Insomnia
• Uncommon (0.1% to 1%): Depression, nightmare^[Ref]

Genitourinary

• Uncommon (0.1% to 1%): Urinary frequency

Amlodipine:

• Common (1% to 10%): Male sexual dysfunction, urinary frequency
• Uncommon (0.1% to 1%): Female sexual dysfunction, micturition frequency, micturition disorder, nocturia
• Frequency not reported: Dysuria, polyuria

Atorvastatin:

• Common (1% to 10%): Urinary tract infection
• Uncommon (0.1% to 1%): Urinary frequency, erectile dysfunction
• Rare (less than 0.1%): White blood cells urine positive^[Ref]

Metabolic

Amlodipine:

• Uncommon (0.1% to 1%): Anorexia, weight gain, weight decrease, hyperglycemia, thirst
• Frequency not reported: Increased appetite

Atorvastatin:

• Common (1% to 10%): Diabetes
• Uncommon (0.1% to 1%): Anorexia
• Rare (less than 0.1%): Hypoglycemia
• Frequency not reported: Hyperglycemia
• Postmarketing reports: Weight increased^[Ref]

Ocular

Amlodipine:

• Uncommon (0.1% to 1%): Abnormal vision, conjunctivitis, diplopia, eye pain
• Frequency not reported: Abnormal visual accommodation, xerophthalmia

Atorvastatin:

• Uncommon (0.1% to 1%): Vision blurred^[Ref]

Hematologic

Amlodipine:

• Uncommon (0.1% to 1%): Leukopenia, thrombocytopenia

Atorvastatin:

• Postmarketing reports: Thrombocytopenia^[Ref]

Further information

Amlodipine/atorvastatin side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer