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Amlodipine / Atorvastatin Dosage

Medically reviewed on August 9, 2017.

Applies to the following strengths: 5 mg-10 mg; 10 mg-10 mg; 5 mg-20 mg; 10 mg-20 mg; 5 mg-40 mg; 10 mg-40 mg; 5 mg-80 mg; 10 mg-80 mg; 2.5 mg-10 mg; 2.5 mg-20 mg; 2.5 mg-40 mg

Usual Adult Dose for Hyperlipidemia

Initial dose: Amlodipine 5 mg-Atorvastatin 10 to 20 mg orally once a day

Maximum dose: Amlodipine 10 mg-Atorvastatin 80 mg orally once a day

Comments:
-Small adult, fragile, or elderly patients may be started on amlodipine 2.5 mg orally once a day.
-Most coronary artery disease patients will require amlodipine 10 mg orally once a day for adequate effect.
-Patients who require greater than 45% low-density lipoprotein (LDL) reduction may be started on atorvastatin 40 mg orally once a day.
-May be titrated for amlodipine after 1 to 2 weeks and for atorvastatin after 2 to 4 weeks.
-Atorvastatin has not been studied in conditions where the major lipoprotein abnormality is elevation of chylomicrons (Fredrickson types I and V).

Usual Adult Dose for Hypertension

Initial dose: Amlodipine 5 mg-Atorvastatin 10 to 20 mg orally once a day

Maximum dose: Amlodipine 10 mg-Atorvastatin 80 mg orally once a day

Comments:
-Small adult, fragile, or elderly patients may be started on amlodipine 2.5 mg orally once a day.
-Most coronary artery disease patients will require amlodipine 10 mg orally once a day for adequate effect.
-Patients who require greater than 45% low-density lipoprotein (LDL) reduction may be started on atorvastatin 40 mg orally once a day.
-May be titrated for amlodipine after 1 to 2 weeks and for atorvastatin after 2 to 4 weeks.
-Atorvastatin has not been studied in conditions where the major lipoprotein abnormality is elevation of chylomicrons (Fredrickson types I and V).

Usual Adult Dose for Angina Pectoris

Initial dose: Amlodipine 5 mg-Atorvastatin 10 to 20 mg orally once a day

Maximum dose: Amlodipine 10 mg-Atorvastatin 80 mg orally once a day

Comments:
-Small adult, fragile, or elderly patients may be started on amlodipine 2.5 mg orally once a day.
-Most coronary artery disease patients will require amlodipine 10 mg orally once a day for adequate effect.
-Patients who require greater than 45% low-density lipoprotein (LDL) reduction may be started on atorvastatin 40 mg orally once a day.
-May be titrated for amlodipine after 1 to 2 weeks and for atorvastatin after 2 to 4 weeks.
-Atorvastatin has not been studied in conditions where the major lipoprotein abnormality is elevation of chylomicrons (Fredrickson types I and V).

Usual Adult Dose for Coronary Artery Disease

Initial dose: Amlodipine 5 mg-Atorvastatin 10 to 20 mg orally once a day

Maximum dose: Amlodipine 10 mg-Atorvastatin 80 mg orally once a day

Comments:
-Small adult, fragile, or elderly patients may be started on amlodipine 2.5 mg orally once a day.
-Most coronary artery disease patients will require amlodipine 10 mg orally once a day for adequate effect.
-Patients who require greater than 45% low-density lipoprotein (LDL) reduction may be started on atorvastatin 40 mg orally once a day.
-May be titrated for amlodipine after 1 to 2 weeks and for atorvastatin after 2 to 4 weeks.
-Atorvastatin has not been studied in conditions where the major lipoprotein abnormality is elevation of chylomicrons (Fredrickson types I and V).

Usual Adult Dose for Prevention of Cardiovascular Disease

Initial dose: Amlodipine 5 mg-Atorvastatin 10 to 20 mg orally once a day

Maximum dose: Amlodipine 10 mg-Atorvastatin 80 mg orally once a day

Comments:
-Small adult, fragile, or elderly patients may be started on amlodipine 2.5 mg orally once a day.
-Most coronary artery disease patients will require amlodipine 10 mg orally once a day for adequate effect.
-Patients who require greater than 45% low-density lipoprotein (LDL) reduction may be started on atorvastatin 40 mg orally once a day.
-May be titrated for amlodipine after 1 to 2 weeks and for atorvastatin after 2 to 4 weeks.
-Atorvastatin has not been studied in conditions where the major lipoprotein abnormality is elevation of chylomicrons (Fredrickson types I and V).

Renal Dose Adjustments

No adjustment recommended

Liver Dose Adjustments

Contraindicated

Precautions

Safety and efficacy have not been established in patients younger than 18 years for the combination product; however, pediatric dosing information is available for the individual components of this drug.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

General:
Atorvastatin:
-Low-density lipoprotein (LDL) reduction remains the same regardless of the time of day of administration.
-LDL reduction is similar when administered with or without food.
-Clinical data suggest greater LDL reduction at any dose in the elderly compared to younger adults.
-There is no clinically significant difference in LDL reduction between genders. Edema, flushing, palpitations, and somnolence appear to be more common in women than in men.

Monitoring:
Atorvastatin:
-Monitor liver enzymes before and during treatment.
-Check lipid levels 2 to 4 weeks after initiation and/or titration and adjust dose accordingly.
-Monitor patients with a history of renal impairment for skeletal muscle effects.

Patient advice:
-Advise patients to promptly report unexplained muscle pain, tenderness, or weakness, particularly if accompanied by malaise or fever; risk of myopathy is increased when taking certain types of medication or consuming greater than 1 L of grapefruit juice.
-Advise patients to promptly report any symptoms that may indicate liver injury, such as fatigue, anorexia, right upper abdominal discomfort, dark urine, or jaundice.
-Advise female patients to stop taking this drug should they become pregnant.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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