Aspirin and omeprazole
Generic name: aspirin and omeprazole [ AS-pir-in-and-oh-MEP-ra-zole ]
Brand name: Yosprala
Dosage form: oral delayed release tablet (325 mg-40 mg; 81 mg-40 mg)
Drug class: Platelet aggregation inhibitors
What is aspirin and omeprazole?
Aspirin and omeprazole is a combination medicine used to help lower the risk of heart problems, strokes, or death in people who have had heart problems caused by blood clots.
Aspirin and omeprazole is also used in people who have had surgery to improve blood flow to the heart and also have another condition that is already being treated with aspirin.
Omeprazole helps reduce the risk of stomach ulcers that may be caused by aspirin, especially in people who are 55 or older, or those who have had stomach ulcers in the past.
Aspirin and omeprazole may also be used for purposes not listed in this medication guide.
Aspirin can make you bleed more easily. Call your doctor if you have any unusual bleeding or bruising, or if you cough up blood or have bloody or tarry stools.
Omeprazole can cause kidney problems. Tell your doctor if you are urinating less than usual, or if you have blood in your urine.
Diarrhea may be a sign of a new infection. Call your doctor if you have diarrhea that is watery or has blood in it.
Omeprazole may cause new or worsening symptoms of lupus. Tell your doctor if you have joint pain and a skin rash on your cheeks or arms that worsens in sunlight.
You may be more likely to have a broken bone while taking aspirin and omeprazole long term or more than once per day.
Before taking this medicine
You should not use this medicine if you are allergic to aspirin or omeprazole, or if:
you are also allergic to medicines like esomeprazole, lansoprazole, pantoprazole, rabeprazole, Nexium, Prevacid, Protonix, and others;
you take medicine that contains rilpivirine (Edurant, Complera, Juluca, Odefsey);
you have had an asthma attack or severe allergic reaction (sneezing, runny or stuffy nose, wheezing, chest pain, shortness of breath) after taking aspirin or another NSAID; or
if you had breathing problems, kidney problems, or a severe allergic reaction after taking this medicine in the past.
Aspirin and omeprazole should not be used to treat a sudden onset of heart attack or stroke symptoms (chest pain, sudden numbness or weakness, slurred speech).
This medicine is not approved for use by anyone younger than 18 years old. Aspirin can cause Reye's syndrome, a serious and sometimes fatal condition in children.
Tell your doctor if you have ever had:
low levels of magnesium in your blood;
a habit of drinking more than 3 alcoholic beverages per day;
liver or kidney disease;
if you are of Asian descent.
You may be more likely to have a broken bone in your hip, wrist, or spine while taking this medicine long-term or more than once per day. Talk with your doctor about ways to keep your bones healthy.
Taking aspirin during late pregnancy may cause bleeding in the mother or the baby during delivery. Tell your doctor if you are pregnant or plan to become pregnant.
This medicine may temporarily affect your ability to get pregnant. Talk with your doctor if this concerns you.
You should not breastfeed while using aspirin and omeprazole.
How should I take aspirin and omeprazole?
Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the lowest dose that is effective in treating your condition.
Take aspirin and omeprazole with a full glass of water. The usual dose is once daily, 1 hour before a meal.
Swallow the tablet whole and do not crush, chew, or break it.
This medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using aspirin and omeprazole.
Omeprazole may affect a drug-screening urine test and you could have false results. Tell the laboratory staff that you use aspirin and omeprazole.
Do not stop using this medicine suddenly, even if you feel fine. Stopping suddenly may increase your risk of heart attack or stroke. Follow your doctor's instructions about tapering your dose.
Store at room temperature away from moisture and heat. Keep the tablets in their original container, along with the packet or canister of moisture-absorbing preservative.
What happens if I miss a dose?
Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time unless your doctor tells you to.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Overdose symptoms may include ringing in your ears, increased thirst, muscle pain or weakness, trouble breathing, or feeling cold.
What should I avoid while taking aspirin and omeprazole?
Ask a doctor or pharmacist before using over-the-counter medicines. They may contain ingredients similar to aspirin or omeprazole.
Taking regular aspirin together with omeprazole (Prilosec) will not work the same way as taking combination aspirin and omeprazole (Yosprala). Do not substitute aspirin and omeprazole with over-the-counter products.
Drinking alcohol can increase your risk of stomach bleeding.
Aspirin and omeprazole side effects
Get emergency medical help if you have signs of an allergic reaction: sneezing, runny or stuffy nose; wheezing or trouble breathing; hives; swelling of your face, lips, tongue, or throat.
Aspirin and omeprazole may cause serious side effects. Call your doctor at once if you have:
severe nausea, vomiting, stomach pain, or diarrhea that is watery or bloody;
bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;
easy bruising, unusual bleeding (such as a nosebleed), or any bleeding that will not stop;
sudden pain or trouble moving your hip, wrist, or back;
kidney problems--fever, rash, nausea, loss of appetite, joint pain, urinating less than usual, blood in your urine, weight gain;
liver problems--stomach pain, itching, dark urine, jaundice (yellowing of the skin or eyes);
low magnesium--dizziness, fast or irregular heart rate, tremors (shaking) or jerking muscle movements, feeling jittery, muscle cramps, muscle spasms in your hands and feet, cough or choking feeling; or
new or worsening symptoms of lupus--joint pain, and a skin rash on your cheeks or arms that worsens in sunlight.
Taking this medicine long-term may cause you to develop stomach growths called fundic gland polyps. Talk with your doctor about this risk.
If you use this medicine for longer than 3 years, you could develop a vitamin B-12 deficiency. Talk to your doctor about how to manage this condition if you develop it.
Common side effects of aspirin and omeprazole may include:
heartburn, stomach pain, indigestion;
nausea, diarrhea; or
chest pain (may happen when you eat).
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What other drugs will affect aspirin and omeprazole?
Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.
Tell your doctor about all your current medicines. Many drugs can affect aspirin and omeprazole, especially:
a diuretic or "water pill;" or
NSAIDs (nonsteroidal anti-inflammatory drugs)--aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others.
This list is not complete and many other drugs may affect aspirin and omeprazole. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
More about aspirin / omeprazole
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- Dosage information
- During pregnancy
- Drug class: platelet aggregation inhibitors
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Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
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