Zilretta Side Effects
Generic name: triamcinolone
Medically reviewed by Drugs.com. Last updated on Oct 6, 2023.
Note: This document contains side effect information about triamcinolone. Some dosage forms listed on this page may not apply to the brand name Zilretta.
Applies to triamcinolone: injection powder for suspension extended release, injection suspension.
Serious side effects of Zilretta
Along with its needed effects, triamcinolone (the active ingredient contained in Zilretta) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur while taking triamcinolone:
- blurred vision
- decrease in the amount of urine
- fast, slow, pounding, or irregular heartbeat or pulse
- mental depression
- mood changes
- noisy, rattling breathing
- numbness or tingling in the arms or legs
- pounding in the ears
- shortness of breath
- swelling of the fingers, hands, feet, or lower legs
- trouble thinking, speaking, or walking
- troubled breathing at rest
- weight gain
Incidence not known
- Abdominal cramping and/or burning (severe)
- abdominal pain
- bloody, black, or tarry stools
- cough or hoarseness
- darkening of skin
- decreased vision
- dry mouth
- eye pain
- eye tearing
- facial hair growth in females
- fever or chills
- flushed, dry skin
- fruit-like breath odor
- full or round face, neck, or trunk
- heartburn and/or indigestion (severe and continuous)
- increased hunger
- increased thirst
- increased urination
- loss of appetite
- loss of sexual desire or ability
- lower back or side pain
- menstrual irregularities
- muscle pain or tenderness
- muscle wasting or weakness
- pain in back, ribs, arms, or legs
- painful or difficult urination
- skin rash
- trouble healing
- trouble sleeping
- unexplained weight loss
- unusual tiredness or weakness
- vision changes
- vomiting of material that looks like coffee grounds
Other side effects of Zilretta
Some side effects of triamcinolone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Incidence not known
- Blemishes on the skin
- dry, scaly skin
- feeling of constant movement of self or surroundings
- full or bloated feeling
- increased appetite
- increased hair growth on the face, forehead, back, arms, and legs
- large, flat, blue, or purplish patches in the skin
- pitting or depression of the skin at the injection site
- reddish purple lines on the arms, face, legs, trunk, or groin
- redness of the skin
- redness, swelling, tenderness, or pain at the injection site
- sensation of spinning
- small, red, or purple spots on the skin
- thin, fragile, or shiny skin
- thinning of the scalp hair
For Healthcare Professionals
Applies to triamcinolone: compounding powder, inhalation aerosol, inhalation aerosol with adapter, injectable kit, injectable suspension, intra-articular powder for injection extended release, intra-articular suspension, oral tablet.
The most commonly occurring adverse effects following local administration have included injection site reaction, headache, and arthralgia. Since systemic absorption may occasionally occur with intra-articular or other local administration, patients may experience adverse effects associated with corticosteroid therapy.[Ref]
Common (1% to 10%): Injection site reaction
Uncommon (0.1% to 1%): Injection site abscess (sterile), injection site irritation, injection site discomfort
Frequency not reported: Post injection flare, brief increased in joint discomfort, excess dosage or too-frequent administration into same site resulting in local subcutaneous atrophy (may return to normal after several months)
Uncommon (0.1% to 1%): Anaphylactoid reaction, anaphylactic reaction, anaphylactoid shock
Common (1% to 10%): Contusions
Uncommon (0.1% to 1%): Urticaria, rash, skin hyperpigmentation, skin hypopigmentation, skin atrophy, skin fragility, petechiae, ecchymosis, erythema, hyperhidrosis, purpura, skin striae, hirsutism, dermatitis acneiform, cutaneous lupus erythematosus, angioedema, pruritus
Frequency not reported: Acne, allergic dermatitis, cutaneous and subcutaneous atrophy, dry scaly skin, ecchymoses and petechiae, edema, erythema, hyperpigmentation, impaired wound healing, increased sweating, lupus erythematosus-like lesions, purpura, rash, sterile abscess, striae, suppressed reactions to skin tests, thin fragile skin, thinning scalp hair, urticaria[Ref]
Common (1% to 10%): Arthralgia, joint swelling
Uncommon (0.1% to 1%): Osteoporosis, osteonecrosis, pathological fracture, fracture delayed union, musculoskeletal discomfort, muscular weakness, myopathy, muscle atrophy, growth retardation, neuropathic arthropathy, myalgia, synovitis
Frequency not reported: Loss of muscle mass, aseptic necrosis of the heads of the humerous and femur, spontaneous fractures, Charcot-like arthropathy[Ref]
Common (1% to 10%): Headache
Uncommon (0.1% to 1%): Convulsion, epilepsy, syncope, benign intracranial hypertension, neuritis, paresthesia, intracranial pressure increased, dizziness
Frequency not reported: Serious neurologic events (with epidural administration)[Ref]
Uncommon (0.1% to 1%): Psychiatric symptom, depression, euphoric mood, mood swings, psychotic disorder, personality change, insomnia, drug dependence, mental disorder, irritability, suicidal ideation, anxiety, cognitive disorder
Uncommon (0.1% to 1%): Peptic ulcer, peptic ulcer perforation, peptic ulcer hemorrhage, pancreatitis, abdominal distension, esophagitis ulcerative, dyspepsia
Frequency not reported: Abdominal distention, nausea[Ref]
Uncommon (0.1% to 1%): Cushingoid, adrenal suppression, secondary adrenocortical insufficiency, hypopituitarism
Frequency not reported: Hirsutism
Frequency not reported: HPA suppression, hypertrichosis[Ref]
Uncommon (0.1% to 1%): Viral eye infection, fungal eye infection, conjunctivitis, blindness, cataract, glaucoma, exophthalmos, corneal perforation, papilledema
Rare (less than 0.1%): Blindness associated with intralesional therapy around the face and head[Ref]
Frequency not reported: Decreased carbohydrate tolerance, manifestation of diabetes mellitus
Frequency not reported: Weight gain[Ref]
Uncommon (0.1% to 1%): Vertigo, fatigue, hyperthermia
Frequency not reported: Malaise
Common (1% to 10%): Infection
Uncommon (0.1% to 1%): Tuberculosis, Candida infection, impaired healing
Frequency not reported: Infection (masked)
Uncommon (0.1% to 1%): Cardiac failure (congestive), arrhythmia, hypertension, embolism, thrombophlebitis, vasculitis necrotizing, hypotension, flushing
Frequency not reported: Bradycardia, cardiac arrest, cardiac arrhythmias, cardiac enlargement, circulatory collapse, congestive heart failure, hypertension, fat embolism, hypertrophic cardiomyopathy in premature infants, myocardial rupture following recent myocardial infarction, pulmonary edema, syncope, tachycardia, thromboembolism, thrombophlebitis, vasculitis, necrotising angiitis, ECG changes due to potassium deficiency[Ref]
Uncommon (0.1% to 1%): Glycosuria, menstrual irregularities, amenorrhea and postmenopausal vaginal bleeding
Frequency not reported: Increased or decreased motility and number of spermatozoa
Frequency not reported: Kaposi's sarcoma
Common (1% to 10%): Sinusitis, cough
Uncommon (0.1% to 1%): Rhinitis
Frequency not reported: Hiccups
Frequently asked questions
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More about Zilretta (triamcinolone)
- Check interactions
- Compare alternatives
- Pricing & coupons
- Reviews (51)
- Dosage information
- During pregnancy
- FDA approval history
- Drug class: glucocorticoids
- En español
Related treatment guides
1. Cerner Multum, Inc. Australian Product Information.
2. Product Information. Zilretta (triamcinolone). Flexion Therapeutics, Inc. 2017.
3. Product Information. Aristospan Injection (triamcinolone). Fujisawa.
4. Burge S. Should inhaled corticosteroids be used in the long term treatment of chronic obstructive pulmonary disease? Drugs. 2001;61:1535-44.
5. Israel E, Banerjee TR, Fitzmaurice GM, Kotlov TV, LaHive K, LeBoff MS. Effects of inhaled glucocorticoids on bone density in premenopausal women. N Engl J Med. 2001;345:941-7.
6. Moshfeghi DM, Lowder CY, Roth DB, Kaiser PK. Retinal and choroidal vascular occlusion after posterior sub-tenon triamcinolone injection. Am J Ophthalmol. 2002;134:132-4.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.