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User Reviews for Zilretta to treat Osteoarthritis

Zilretta has an average rating of 5.7 out of 10 from a total of 48 ratings for the treatment of Osteoarthritis. 44% of reviewers reported a positive experience, while 46% reported a negative experience.

Zilretta rating summary

5.7/10 average rating

48 ratings from 49 user reviews.

Compare all 172 medications used in the treatment of Osteoarthritis.

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Reviews for Zilretta

AT · Taken for 1 to 2 years · April 14, 2021

"For years my pain management doctor tried different medicines, but all worked about 1 to 2 weeks. When a new pain management doctor entered the practice, she suggested that we try Zilretta. Pain was almost immediately gone and it lasts for 2 months. Then I can manage the pain with Aleve for the next month. Zilretta has changed my life. I have been having the injections in my right knee for almost 2 years now. Have noticed no side effects."

9 / 10
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Swampbabe · November 10, 2020

"I am in the last stages of osteoarthritis in both knees. I pretty young to have knees as bad as I do (so my doctor says) I’m 52 and have been fighting osteoarthritis for 12 years now. I had Zilretta injections in Jan 2020 and it was amazing for the pain. I was pain free for 3 months. My range of motion stayed the same but I had no pain! The only negative thing is when the injections wore off I had no warning of the pain coming back, it came back with a vengeance. I scheduled knee surgery for August and cancelled because of the corona virus. So today I had zilretta injections again to buy time until I feel safe to have surgery! These injections have been the only thing that works for me and I’m so grateful to be pain free even if it is only for 3 months!"

10 / 10
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DJA · Taken for 1 to 6 months · November 3, 2019

"I have tried all available types of injections for my right knee and I have had less and less effectiveness with each injection. Zilretta has been a miracle drug as it has given me pain and swelling relief for two months. I am very active. I jog about 15-20 miles a week and walk about another 5 miles per week. Before Zilretta I did it with pain and a limp - not now!"

10 / 10
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Frequently asked questions

Kat · Taken for less than 1 month · October 6, 2018

"One day I was hobbling at work , walking with a cane. I was done! Some days I couldn’t get up out of a chair. My Dr told me about Zilretta injections for both my knees . I was shock my insurance covered it! Only $50 for both knees. Had both knees drained and injections with Zilretta. WOW! After 2 days of ice I stood up and walked normal for the first time in 12 years I had no knee pain at all. I had little to no swelling from the knees down. I have told everyone I know about Zilretta! So happy to be pain free! Thank you!"

10 / 10
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Anonymous · Taken for 1 to 6 months · June 24, 2019

"Since getting injection of zilretta after years of cortisone injections for bone on bone in my knees, my worse knee has gotten unbearable. I now not only have knee pain but it feels like a rubber band breaking behind my kneecap and excruciating nerve pain down my whole left leg, even while sleeping. I don't recommend getting this shot. Because of it, I now will have to have my knee replaced sooner rather than later."

2 / 10
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Anonymous · March 26, 2019

"I have bone on bone in both needs and have been in horrible pain for about a year. I have have cortizone injections in the past, with last one only getting relief for a week. I was completely at my wits end . I am only 58 years old and am trying to hold off on knee replacement surgery for as long as possible. My prayers have been answered with Zilretta, I had an injection in both knees 8 days ago and I feel like a new person. I pray the relief continues. I would recommend this to everyone suffering with knee pain."

9 / 10
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SusieQ · Taken for 6 months to 1 year · September 13, 2018

"I have had Zilretta injections in both of my knees. It is absolutely FANTASTIC ! I was pain free the 1st day after my injection. I did not have any side effects. I can do things I haven't been able to do for years. Going up and down stairs is so much easier now. I can stand in one place for and extended period of time. I can kneel on the floor and play with my Grand kids. I feel like a new person being pain free. I would recommend anyone with Osteoarthritis to try Zilretta."

10 / 10
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More FAQ

nuke · Taken for 1 to 6 months · January 23, 2019

"I've had medial left knee pain for awhile and tried different avenues of pain management, including hyaluronic acid injections. Zilretta is awesome! It took a good week for it to kick in, but I am now at one month and the pain has subsided immensely. No side effects at all. I'm very active and play a lot of pickleball, so I'm a true test to the effectiveness of this drug."

10 / 10
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Marty · Taken for less than 1 month · February 6, 2019

"I've had every knee shot for knee osteoarthritis with no results. I've had moderate to severe knee pain for five years. I had my left knee injected two weeks ago and got immediate results. Pain free! Yesterday I had my right knee injected with the same results. Zilretta is amazing! Curious to see how long the shots will last."

10 / 10
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NeNe · Taken for 6 months to 1 year · May 3, 2019

"MAN!!! Where do I start? Both knees are shot but I’m unable to do surgery at this time because of mother-in-law broken hip and recent major surgery on son so we’re taking care of them. ZILRETTA is fantastic for my osteoarthritis it works and it lasts for about 3 months I have been taking the injections about 9 months. Before that Dr was doing steroid injections that last almost 2-3 weeks. Greatest product."

10 / 10
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Tag · Taken for 1 to 6 months · September 19, 2019

"I also have bone on bone in my knee. I was using cortisone injections and then doctor told me about Zilretta. I got the injection in May and by August it was wearing off. I am in more pain now than ever before. It felt great at first but WOW. I do not recommend this."

2 / 10
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Haven · Taken for 6 months to 1 year · May 26, 2019

"The first set of injections kept me in pain and off of my feet for over a week. I've had to get the injections every 3 months instead of every 6 like my last medication. Every time it is the same thing, both knees end up swollen and painful for a week or longer. The effects of Zilretta are semi-beneficial for about 8 weeks. I've had a lot more pain, stiffness and swelling in my knees since taking Zilretta. There are days that I can't fully straighten or bend my legs. The inflammation is bad and my symptoms are becoming worse then they were before I started Zilretta. This is a serious concern. I'm glad that it is helping some people, but for me the short 8 weeks of slight relief is not worth the pain and worsening of symptoms that I have for the rest of the time between injections."

4 / 10
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M monroe · Taken for 1 to 6 months · February 10, 2020

"I have had two shots of zilretta in my right knee.The shot lasts exactly 90 days. About 48 hours after receiving this shot all pain is gone and I feel like I have a brand new knee. But I have to fight with my Federal Blue Cross Blue Shield to pay for this shot. It is a great shot if you can schedule the shot exactly every 90 days. The company that manufactures this drug offers no discounts and no coupons or financial help. Even with insurance this shot costs 240 dollars."

10 / 10
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Jillyn31 · Taken for 1 to 6 months · May 12, 2018

"I got an injection in my right knee a month ago today (Dr had sample). I was a little worried about it containing steroids, because I've previously had them worsen my mental health symptoms, but I didn't have too many problems with that this time. Of course, after the injection, my knee was sore & swollen, making it difficult to walk right for a few days. I noticed nasal congestion, which is one of the side effects. Since it's extended release, I expected the osteoarthritis pain & swelling in my knee to go down, at least a little bit over time. To date, it hasn't & has actually gotten worse. I've also noticed increased knee stiffness & leg spasms (feels like they're behind the knee cap), that I didn't have before. I was looking forward to this med providing much needed relief, not causing issues. At this point, I'm not planning to get my left knee done. Just not the results I expected. Although I don't believe it's at all related, I will be fair & mention I also have fibromyalgia."

3 / 10
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Anonymous · Taken for 6 months to 1 year · June 6, 2019

"Some mild pain and inflammation relief but that lasted just a little while. It's supposed to last a long time but my knee is pretty much worse than before I started the Zirletta injection. I can't say if that's the natural progression or the cortisone sped it up. But I can say that the regular cortisone shot I got before Zirletta was way more effective. I would not recommend Zirletta."

3 / 10
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anonymous1234 · Taken for 6 months to 1 year · April 2, 2019

"I had high hopes for this injection after failed cortisone, and other injections. I iced my knee several times a day. I have a bit of relief in my knee but by the end of the day I'm "toast". It has been one week since my injection. I'm glad others had success, however, it is not working for me."

3 / 10
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Sunshine · August 12, 2020

"I got my first injection when I was 62 years old. It lasted for 10 months!! I am now 63 and just got a second injection today! My experience the first round was Amazing! I could walk, climb, play on the floor and even do Zumba again! Looking forward to the next 10 months of amazing mobility!"

10 / 10
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TOPCAT LTKR · Taken for 2 to 5 years · April 6, 2021

"I had Zilretta injections several times in my left knee which was bone to bone from degenerative arthritis at age 73 and I am a big man of 200 pounds. First injection gave partial relief for about 9-10 weeks maximum and each consecutive dose less effective down to about 4 weeks of relief with last dose. A big problem is they would only give another injection after 90 days so waiting for the next dose meant a lot of pain between doses. I quickly realized it is pain management only and the degenerative condition gets worse as you do more activity on the knee with reduced pain. So surgery is inevitable. You might as well go ahead with TKR. Also, it is a steriod. Several of my injections were painful at injection time and fact was for me, the surgeon delayed my surgery by 120 days saying Zilretta, as a steriod, gave increased risk of infection if given close to surgery date. I would not do it again. I would opt for TKR as soon as pain of bone to bone appears. They do not tell all up front."

3 / 10
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Kat · November 3, 2020

"Zilretta was a total disaster, I haven’t walked for a month. Felt sick within an hour after receiving Zilretta. I only hope this lasts the length Of the drug and doesn’t permanently damage my knees. THIS WAS NO MIRACLE. I’m a thousand times worse than I was."

1 / 10
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John Jones · August 28, 2021

"I had an injection of Zilretta 3 years ago for arthritis in my right knee and so far I still am not experiencing pain. They tried cortisone and it didn’t work. I don’t know if three months is an estimate on how long it works but I’m going on 4 years and so far I am pain free."

10 / 10
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DJA · Taken for 6 months to 1 year · March 14, 2020

"Second injection relieved knee pain but not as good as first. The good results were less pain, more flexibility, and less swelling. The noticed side effects after the second shot were like an allergic reaction with moderate congestion, slight cough. My reaction immediately after receiving the injection was more noticeable than the first with flu like feelings for a few days. All in all the pain relief has been good but I am not sure about a third injection. It may be time to fix the problem rather than treat the symptoms."

7 / 10
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DanA · Taken for less than 1 month · January 27, 2020

"I had a shot of this medication in my knee and I have had severe leg cramps and we I asked the doctor about how long the side effects were going to last he said 3 to 4 days. At this point I can hardly walk.. I definitely would not recommend this drug. Additionally I believe Cortizone is better in this stuff. Good night cramps are unbearable I drink a lot of water to stay hydrated."

1 / 10
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Anonymous · Taken for less than 1 month · July 30, 2020

"I have partial replacements in both knees and they are both bad again. I got the Zilretta shot a week ago and had great pain relief at first but on day 7 started increasing pain. Not sure if this is gonna work. Trying to buy time before total replacements."

2 / 10
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MyKnees · Taken for less than 1 month · December 4, 2020

"Don’t bother with Zilretta. I have been getting conventional cortisone knee injections for several years - tried Zilretta in an attempt to reduce frequency of injections. Three weeks out and minimal relief compared to conventional cortisone. Now I have to wait several months before I can get regular cortisone again."

1 / 10
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Pk · July 16, 2021

"Got first zilretta yesterday. No pain relief yesterday. Woke up today with almost no pain. So far best pain relief ever. My pain usually 4-7 Scale but today maybe 1 after doing errands and walking 3 stores. Praying it works for a few months."

9 / 10
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This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.