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How is Zilretta administered?

Medically reviewed by Judith Stewart, BPharm. Last updated on May 10, 2023.

Official answer


Zilretta (triamcinolone acetonide extended-release injectable suspension) is administered as an intra-articular injection into the knee joint.

Zilretta is indicated for the management of osteoarthritis pain of the knee.

Zilretta contains triamcinolone acetonide, a commonly administered, short-acting corticosteroid formulated in poly lactic-co-glycolic acid (PLGA) microspheres to provide long acting pain relief over 12 weeks.

Zilretta works by reducing inflammation to decrease acute episodes of pain and increase joint mobility.

Common side effects of Zilretta include joint pain, headache, joint swelling, back pain, sore throat and runny nose, upper respiratory tract infection, and bruising.

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