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Zilretta Dosage

Dosage form: extended-release injectable suspension kit
Drug class: Glucocorticoids

Medically reviewed by Last updated on Dec 8, 2023.

Important Dosage and Administration Information

  • ZILRETTA is administered as a single intra-articular extended-release injection of triamcinolone acetonide, to deliver 32 mg (5 mL).
  • ZILRETTA is for intra-articular use only and should not be administered by the following routes: epidural, intrathecal, intravenous, intraocular, intramuscular, intradermal, subcutaneous.
  • ZILRETTA is not suitable for use in small joints, such as the hand.
  • The efficacy and safety of repeat administration of ZILRETTA have not been demonstrated [see Adverse Reactions (6) and Nonclinical Toxicology (13.2)].
  • The efficacy and safety of ZILRETTA for management of osteoarthritis pain of shoulder and hip have not been evaluated.

Preparation and Administration of Intra-Articular Suspension

Refer to the Instructions for Use for directions on the preparation and administration of ZILRETTA.

ZILRETTA is supplied as a single-dose kit containing a vial of ZILRETTA microsphere powder, a vial of sterile diluent, and a sterile vial adapter.

ZILRETTA must be prepared using the diluent supplied in the kit.

Preparation of ZILRETTA requires close attention to the Instructions for Use to ensure successful administration.

Use proper aseptic technique throughout the dose preparation and administration procedure.

ZILRETTA is a suspension product and it is normal for some residue to be left behind on the vial walls after withdrawing the contents.

Promptly inject ZILRETTA after preparation to avoid settling of the suspension. If needed, the ZILRETTA suspension can be stored in the vial for up to 4 hours at ambient conditions. Gently swirl the vial to resuspend any of the settled microspheres prior to preparing the syringe for injection.

The usual technique for intra-articular injection should be followed. Aspiration of synovial fluid may be performed based on clinical judgment prior to administration of ZILRETTA.

Non-Interchangeability with Other Formulations of Triamcinolone Acetonide for Intra-articular Use

ZILRETTA is not interchangeable with other formulations of injectable triamcinolone acetonide.

Frequently asked questions

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.