Wixela Inhub Side Effects

Generic name: fluticasone / salmeterol

Medically reviewed by Drugs.com. Last updated on Nov 9, 2023.

Note: This document provides detailed information about Wixela Inhub Side Effects associated with fluticasone / salmeterol. Some dosage forms listed on this page may not apply specifically to the brand name Wixela Inhub.

Applies to fluticasone / salmeterol: inhalation aerosol liquid, inhalation disk, inhalation powder.

Serious side effects of Wixela Inhub

Along with its needed effects, fluticasone/salmeterol may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking fluticasone / salmeterol:

Get emergency help immediately if any of the following symptoms of overdose occur while taking fluticasone / salmeterol:

Symptoms of overdose

• chest pain or tightness
• confusion
• decreased urine output
• dry mouth
• faintness, or lightheadedness when getting up suddenly from a lying or sitting position
• general feeling of discomfort or illness
• high blood pressure
• loss of appetite
• mood changes
• nervousness
• numbness or tingling in the hands, feet, or lips
• seizures
• sudden sweating
• tremors
• trouble with sleeping

Other side effects of Wixela Inhub

Some side effects of fluticasone / salmeterol may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For healthcare professionals

Applies to fluticasone / salmeterol: inhalation aerosol, inhalation powder.

General

The most common events that occurred more frequently were nasopharyngitis, upper respiratory tract infection, nasal congestion, back pain, sinusitis, dizziness, nausea, pneumonia, candidiasis, and dysphonia.^[Ref]

Nervous system

• Very common (10% or more): Headache (up to 21%)
• Common (1% to 10%): Migraine
• Uncommon (0.1% to 1%): Tremor
• Postmarketing reports: Paraesthesia, restlessness, compressed nerve syndrome, aphonia^[Ref]

Respiratory

• Very common (10% or more): Upper respiratory tract infections (up to 27%), pharyngitis (up to 13%), nasopharyngitis
• Common (1% to 10%): Pneumonia, bronchitis, throat irritation, hoarseness, dysphonia, sinusitis, upper respiratory inflammation, viral respiratory infections, cough, rhinorrhea/postnasal drip, epistaxis, nasal congestion/blockage, laryngitis, unspecified oropharyngeal plaques, dryness of nose, lower respiratory signs and symptoms, lower respiratory infections, lower respiratory hemorrhage, congestion
• Uncommon (0.1% to 1%): Dyspnea
• Rare (less than 0.1%): Oropharyngeal angioedema, bronchospasm, paradoxical bronchospasm
• Frequency not reported: Nose, and throat infections, laryngitis, nasal sinus disorders, nasal sinus disorders
• Postmarketing reports: Paranasal sinus pain, rhinitis, throat soreness, tonsillitis, asthma, asthma exacerbation, chest congestion, chest tightness, tracheitis, wheezing, report of upper respiratory symptoms of laryngeal spasm, irritation, or swelling such as stridor or chocking^[Ref]

The incidence of pneumonia was higher in adult subjects with COPD older than 65 years compared with younger subjects with COPD (18% versus 14%).^[Ref]

Cardiovascular

• Common (1% to 10%): Palpitations, tachycardia, arrhythmias, myocardial infarction, postoperative complications
• Uncommon (0.1% to 1%): Atrial fibrillation, angina pectoris
• Rare (less than 0.1%): Cardiac arrhythmias (including supraventricular tachycardia and extrasystoles)
• Frequency not reported: Hematomas
• Postmarketing reports: Ventricular tachycardia, pallor^[Ref]

Dermatologic

• Common (1% to 10%): Contusions, wounds, eczema, dermatitis, dermatosis
• Frequency not reported: Skin flakiness and acquired ichthyosis, disorders of sweat and sebum
• Postmarketing reports: Ecchymoses, photodermatitis^[Ref]

Gastrointestinal

• Common (1% to 10%): Oral and throat candidiasis, nausea and vomiting, gastrointestinal discomfort and pain, dental discomfort and pain, hyposalivation, gastrointestinal infections, disorders of hard tissue of teeth, abdominal discomfort and pain, oral abnormalities, gastrointestinal discomfort and pain, viral gastrointestinal infections, diarrhea
• Rare (less than 0.1%): Esophageal candidiasis
• Frequency not reported: Oral lesions
• Postmarketing reports: Oral ulcerations, dyspepsia, xerostomia^[Ref]

Immunologic

• Common (1% to 10%): Allergies and allergic reactions^[Ref]

Metabolic

• Common (1% to 10%): Hypokalemia, weight gain
• Uncommon (0.1% to 1%): Hyperglycemia
• Frequency not reported: Fluid retention^[Ref]

Musculoskeletal

• Common (1% to 10%): Muscle cramps, traumatic fractures, arthralgia, myalgia, arthralgia, articular rheumatism, muscle spasms, musculoskeletal inflammation, bone and skeletal pain, muscle injuries, soft tissue injuries
• Postmarketing reports: Muscle stiffness, tightness and rigidity, bone and cartilage disorders, myositis, osteoporosis, fractures^[Ref]

Ocular

• Common (1% to 10%): Allergic eye disorders, eye edema and swelling
• Uncommon (0.1% to 1%): Cataract
• Rare (less than 0.1%): Glaucoma
• Frequency not reported: Dry eyes, eye infections, keratitis, conjunctivitis^[Ref]

Other

• Common (1% to 10%): Candidiasis unspecified site, ear signs and symptoms, viral infections, bacterial infections, inflammation, bacterial reproductive infections
• Rare (less than 0.1%): Angioedema, facial angioedema
• Frequency not reported: Syncope, edema and swelling, dysmenorrhea, pain, unusual taste, lacerations
• Postmarketing reports: Ear ache, fever^[Ref]

Hypersensitivity

• Uncommon (0.1% to 1%): Cutaneous hypersensitivity reactions
• Rare (less than 0.1%): Anaphylactic reactions including anaphylactic shock^[Ref]

Psychiatric

• Uncommon (0.1% to 1%): Anxiety, sleep disorders
• Rare (less than 0.1%): Behavioral changes, including psychomotor hyperactivity and irritability (predominately in children)
• Frequency not reported: Depression, aggression (predominantly in children)
• Postmarketing reports: Agitation^[Ref]

Endocrine

• Rare (less than 0.1%): Cushing's syndrome, Cushingoid features, adrenal suppression, growth retardation in children and adolescents, decrease bone mineral density
• Frequency not reported: Hypothyroidism
• Postmarketing reports: Hypercorticism^[Ref]

Hepatic

• Frequency not reported: Abnormal liver function tests^[Ref]

Frequently asked questions

• Is Wixela Inhub the same as Advair Diskus?
• Symbicort vs. Advair: How do they compare?

Further information

Wixela Inhub side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer