Generic Name: fluticasone and salmeterol (floo TIK a sone, sal ME te rol)
Brand Name: Advair Diskus, Advair HFA
What is Advair HFA (fluticasone and salmeterol)inhalation?
Fluticasone is a steroid that prevents the release of substances in the body that cause inflammation. Salmeterol is a bronchodilator. It works by relaxing muscles in the airways to improve breathing.
Fluticasone and salmeterol inhalation is a combination medicine used to prevent asthma attacks. It is also used to prevent flare-ups or worsening of chronic obstructive pulmonary disease (COPD) associated with chronic bronchitis and/or emphysema.
In people with COPD, fluticasone and salmeterol is for long-term treatment. In people with asthma, this medicine is for short-term treatment until symptoms are well controlled with with other medicines.
Advair Diskus is for use in adults and children who are at least 4 years old. Advair HFA is for use in adults and children who are at least 12 years old.
Salmeterol may increase the risk of death in people with asthma, but the risk in people with COPD is not known. Talk with your doctor about your individual risks and benefits of using this medicine.
Fluticasone and salmeterol may also be used for purposes not listed in this medication guide.
What is the most important information I should know about Advair HFA (fluticasone and salmeterol)?
You should not use this medicine if you are allergic to fluticasone, salmeterol, or milk proteins.
Fluticasone and salmeterol is not a rescue medicine. It will not work fast enough to treat an asthma or bronchospasm attack.
Salmeterol may increase the risk of death in people with asthma, but the risk in people with COPD is not known.
What should I discuss with my healthcare provider before using Advair HFA (fluticasone and salmeterol)?
You should not use this medicine if you are allergic to fluticasone or salmeterol (Serevent), or:
if you have a severe allergy to milk proteins; or
if you are having an asthma attack or severe COPD symptoms.
To make sure this medicine is safe for you, tell your doctor if you have:
a food or drug allergy;
heart disease or high blood pressure;
epilepsy or other seizure disorder;
any type of infection;
a weak immune system;
a thyroid disorder; or
Long-term use of steroids may lead to bone loss (osteoporosis), especially if you smoke, if you do not exercise, if you do not get enough vitamin D or calcium in your diet, or if you have a family history of osteoporosis.
It is not known whether fluticasone and salmeterol is harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medicine.
It is not known whether this medicine passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.
Fluticasone and salmeterol inhalation can affect growth in children. Talk with your doctor if you think your child is not growing at a normal rate while using this medication.
This medicine is not approved for use by anyone younger than 4 years old.
How should I use Advair HFA (fluticasone and salmeterol)?
Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not use this medicine in larger or smaller amounts or for longer than recommended.
Fluticasone and salmeterol is not a rescue medicine. It will not work fast enough to treat an asthma attack. Use only a fast acting inhalation medicine for an asthma attack.
Tell your doctor if any of your medicines seem to stop working as well in controlling your symptoms.
Advair Diskus is a powder form of fluticasone and salmeterol that comes with a special inhaler device pre-loaded with blister packs containing measured doses of the medicine. The device opens and loads a blister each time you use the inhaler. This device is not to be used with a spacer.
Advair HFA is an aerosol form of fluticasone and salmeterol that comes in a canister that is used with an actuator inhaler device. Use only the inhaler device provided with Advair HFA.
Shake the Advair HFA inhaler for at least 5 seconds before each spray.
To reduce the chance of developing a yeast infection in your mouth, rinse with water after using your inhaler. Do not swallow.
Keep track of the number of sprays you have used and throw away the Advair HFA canister after 120 sprays, even if it feels like there is still medicine in it.
Your doctor will need to check your lung function on a regular basis. Once your asthma is under control, your doctor may want you to stop using this medicine. Keep all follow-up appointments and do not stop using the medicine unless your doctor tells you to.
If you also use an oral steroid medication, you should not stop using it suddenly. Follow your doctor's instructions about tapering your dose. Carry an identification card or wear a medical alert ID to let others know that you may need an oral steroid in an emergency.
Your dose needs may change if you have surgery, are ill, are under stress, or have recently had an asthma attack. Do not change your medication dose or schedule without your doctor's advice.
Seek medical attention if your breathing problems do not improve, or if your symptoms get worse quickly. If you use a peak flow meter at home, call your doctor if your numbers are lower than normal.
While using this medicine, your vision and your bone mineral density may need to be checked often.
Store at room temperature away from moisture, heat, and light. Keep the Advair HFA canister away from high heat, such as open flame or in a car on a hot day. The canister may explode if it gets too hot.
Throw the inhaler device away 1 month after you have taken it out of the foil pouch, or if the dose indicator shows a zero, whichever comes first.
What happens if I miss a dose?
Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include angina or chest pain, fast or irregular heartbeats, seizures, tremor, weakness, headache, nausea, and vomiting.
What should I avoid while using Advair HFA (fluticasone and salmeterol)?
Do not use a second form of salmeterol (such as Serevent) or use a similar inhaled bronchodilator such as formoterol (Foradil, Symbicort, Dulera), arformoterol (Brovana), or vilanterol (Bree Ellipta, Anoro Ellipta) unless your doctor has told you to.
Avoid being near people who are sick or have infections. Call your doctor for preventive treatment if you are exposed to chicken pox or measles. These conditions can be serious or even fatal in people who are using steroid medicine.
Advair HFA (fluticasone and salmeterol) side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
wheezing, choking, or other breathing problems after using this medicine;
chest pain, fast or uneven heart beats, restless feeling, tremors;
severe headache, pounding in your neck or ears, nosebleed;
fever, chills, swollen glands, mouth sores, skin sores, flu symptoms, cough with yellow or green mucus;
blurred vision, tunnel vision, eye pain, or seeing halos around lights;
high blood sugar--increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin;
low potassium--confusion, uneven heart rate, extreme thirst, increased urination, leg discomfort, muscle weakness or limp feeling; or
signs of a hormonal disorder--worsening tiredness or muscle weakness, feeling light-headed, anxiety, feeling irritable, nausea, vomiting, loss of appetite, diarrhea, weight loss, weight gain, slow wound healing.
Common side effects may include:
headache, muscle pain, bone pain;
throat irritation, white patches in the mouth or throat;
cold symptoms such as stuffy nose, sneezing, sore throat; or
ongoing cough, hoarseness or deepened voice.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
What other drugs will affect Advair HFA (fluticasone and salmeterol)?
Many drugs can interact with this medicine. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any you start or stop using, especially:
antifungal medicine such as ketoconazole; or
ritonavir (Norvir) or lopinavir/ritonavir (Kaletra).
This list is not complete and many other drugs can interact with fluticasone and salmeterol. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you.
More about Advair HFA (fluticasone / salmeterol)
- Advair HFA Inhaler
- Advair HFA (Advanced Reading)
- Advair HFA 115/21 (Advanced Reading)
- Advair HFA 230/21 (Advanced Reading)
- Advair HFA 45/21 (Advanced Reading)
- Advair Inhalation Aerosol (Advanced Reading)
- Other brands: Advair Diskus
Related treatment guides
Where can I get more information?
- Your pharmacist can provide more information about fluticasone and salmeterol inhalation.
- Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
- Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2012 Cerner Multum, Inc. Version: 11.02.
Last reviewed: September 13, 2016
Date modified: November 30, 2016