Generic Name: fluticasone and salmeterol (floo TIK a sone, sal ME te rol)
Brand Names: Advair Diskus, Advair HFA, AirDuo RespiClick
Medically reviewed on February 4, 2018
What is Advair?
Advair contains a combination of fluticasone and salmeterol. Fluticasone is a steroid that prevents the release of substances in the body that cause inflammation. Salmeterol is a bronchodilator. It works by relaxing muscles in the airways to improve breathing.
Advair inhalation is a combination medicine used to prevent asthma attacks. It is also used to prevent flare-ups or worsening of chronic obstructive pulmonary disease (COPD) associated with chronic bronchitis and/or emphysema.
In people with COPD, Advair is for long-term treatment. In people with asthma, this medicine is for short-term treatment until symptoms are well controlled with with other medicines.
Advair is for use in adults and children who are at least 4 years old. Advair HFA is for use in adults and children who are at least 12 years old.
Salmeterol when used alone may increase the risk of death in people with asthma. However, this risk is not increased when Advair are used together as a combination product.
You should not use Advair if you are allergic to fluticasone, salmeterol, or milk proteins.
Advair is not a rescue medicine. It will not work fast enough to treat an asthma or bronchospasm attack.
Seek medical attention you have worsening breathing problems, or if you think your medications are not working as well.
Before taking this medicine
You should not use Advair if you are allergic to fluticasone or salmeterol (Serevent), or:
if you have a severe allergy to milk proteins; or
if you are having an asthma attack or severe COPD symptoms.
Fluticasone can weaken your immune system, making it easier for you to get an infection or worsening an infection you already have or have recently had. Tell your doctor about any illness or infection you have had within the past several weeks.
To make sure Advair is safe for you, tell your doctor if you have ever had:
a food or drug allergy;
heart disease or high blood pressure;
epilepsy or other seizure disorder;
glaucoma or cataracts;
any type of infection (bacterial, fungal, viral, or parasitic);
a thyroid disorder; or
Long-term use of steroids may lead to bone loss (osteoporosis), especially if you smoke, if you do not exercise, if you do not get enough vitamin D or calcium in your diet, or if you have a family history of osteoporosis.
It is not known whether Advair is harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
It is not known whether fluticasone and salmeterol passes into breast milk or if it could affect the nursing baby. Tell your doctor if you are breast-feeding.
This medicine is not approved for use by anyone younger than 4 years old.
How should I use Advair?
Use Advair exactly as it was prescribed for you. Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended. Using too much of this medicine can cause life-threatening side effects. Tell your doctor if you think your medications are not working as well.
Advair is not a rescue medicine. It will not work fast enough to treat an asthma attack. Use only a fast-acting inhalation medicine for an asthma attack.
Advair Diskus is a powder form of fluticasone and salmeterol that comes with a special inhaler device pre-loaded with blister packs containing measured doses of the medicine. The device opens and loads a blister each time you use the inhaler.
Advair HFA comes in a canister that is used with an actuator inhaler device.
Use only the inhaler device provided with your medication.
Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions.
Shake the Advair HFA inhaler for at least 5 seconds before each spray.
Rinse your mouth with water after each use of your inhaler.
If you also use an oral steroid medication, you should not stop using it suddenly. Follow your doctor's instructions about tapering your dose.
While using Advair, your vision and your bone mineral density may need to be checked often.
Seek medical attention if your breathing problems do not improve, or if your symptoms get worse quickly. If you use a peak flow meter at home, call your doctor if your numbers are lower than normal.
Store your medicine at room temperature away from moisture, light, and heat (especially high heat, such as open flame or in a car on a hot day).
Throw the inhaler device away 1 month after you took it out of the foil pouch, or if the dose indicator shows a zero (even if it feels like there is still medicine inside).
Once your asthma is under control, your doctor may want you to stop using this medicine. Keep all follow-up appointments and do not stop using the medicine unless your doctor tells you to.
See also: Dosage Information (in more detail)
What happens if I miss a dose?
Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Overdose symptoms may include chest pain, fast heart rate, and feeling shaky or short of breath.
What should I avoid while using Advair?
Avoid being near people who are sick or have infections. Call your doctor for preventive treatment if you are exposed to chicken pox or measles. These conditions can be serious or even fatal in people who are using a steroid such as fluticasone.
Do not use a second inhaled bronchodilator unless your doctor tells you to. This includes formoterol (Perforomist, Symbicort, Bevespi, Dulera), arformoterol (Brovana), indacaterol (Arcapta), olodaterol (Striverdi, Stiolto Respimat), salmeterol (Serevent), or vilanterol (Breo Ellipta, Anoro Ellipta).
Advair side effects
Get emergency medical help if you have signs of an allergic reaction to Advair: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
wheezing, choking, or other breathing problems after using this medicine;
chest pain, fast or uneven heart beats, restless feeling, tremors;
severe headache, pounding in your neck or ears, nosebleed;
sores or white patches in your mouth or throat, trouble swallowing;
blurred vision, tunnel vision, eye pain, or seeing halos around lights;
high blood sugar - increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin;
low potassium - confusion, uneven heart rate, extreme thirst, increased urination, leg discomfort, muscle weakness or limp feeling; or
Fluticasone can affect growth in children. Talk with your doctor if you think your child is not growing at a normal rate while using this medication.
Common Advair side effects may include:
ongoing cough, hoarseness or deepened voice.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
What other drugs will affect Advair?
Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.
Many drugs can interact with this medicine. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any you start or stop using, especially:
heart or blood pressure medicine;
a diuretic or "water pill";
antifungal medicine such as ketoconazole; or
This list is not complete and many other drugs can interact with fluticasone and salmeterol. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Advair only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Copyright 1996-2018 Cerner Multum, Inc. Version: 13.01.
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