Generic Name: tiotropium inhalation (tye oh TROE pee um)
Brand Names: Spiriva, Spiriva Respimat (14 dose, 30 dose)
What is Spiriva?
Spiriva (tiotropium) is a bronchodilator that relaxes muscles in the airways and increases air flow to the lungs.
Spiriva Respimat is used long term for the prevention of bronchospasm in COPD, and for the maintenance treatment of asthma in patients 12 years of age and older.
Spiriva also reduces the likelihood of flare-ups and worsening of COPD symptoms.
A Spiriva capsule is for use only in the HandiHaler device. Do not take the capsule by mouth. Use only one capsule at a time.
Before using tiotropium, tell your doctor if you have narrow-angle glaucoma, or an enlarged prostate or bladder obstruction.
Spiriva is used to prevent bronchospasm attacks. Do not use this medication to treat a bronchospasm attack that has already begun. It will not work fast enough to reverse your symptoms. Use only a fast-acting inhalation medication to treat an attack.
Before taking this medicine
You should not use Spiriva if you are allergic to tiotropium or ipratropium (Atrovent, Combivent, DuoNeb).
To make sure this medicine is safe for you, tell your doctor if you have:
enlarged prostate or urination problems;
if you are allergic to milk; or
if you also take medicine to treat Parkinson's disease, overactive bladder, irritable bowel syndrome, depression, high blood pressure, or muscle spasms.
It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
It is not known whether tiotropium inhalation passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding or plan to breast-feed a baby.
Spiriva is not approved for use by anyone younger than 18 years old.
How should I use Spiriva?
Use Spiriva exactly as prescribed by your doctor. The usual dose of this medicine is 2 inhalations (puffs) through the mouth once daily. Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.
Spiriva is not a rescue medicine. It will not work fast enough to treat a COPD flare-up. Your doctor may prescribe a fast-acting inhalation medicine to treat a bronchospasm attack. Tell your doctor if it seems like your medications don't work as well.
Spiriva comes with patient instructions for safe and effective use, and directions for priming the inhaler device. Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions.
Tiotropium inhalation powder (Spiriva HandiHaler) is packaged in capsules that come with a special inhaler device. Each time you use the medicine, load a capsule into the device and click the mouthpiece closed. Push the button on the side of the device to pierce the capsule and release the medicine into the inhalation chamber. You will need 2 inhalations to get the full dose from 1 capsule.
Do not take the capsule by mouth. Spiriva capsules are for use only in the HandiHaler device. Use only 1 capsule at a time. Do not use the HandiHaler device to take any other medicine.
Keep each Spiriva capsule in its blister pack until you are ready to place the capsule into the HandiHaler and use the device. Throw away any capsule that is not used right after you have taken it out of the blister pack. Exposure to air can ruin the capsule.
Tiotropium inhalation aerosol (Spiriva Respimat) comes in a cartridge that is inserted into a special inhaler device provided with this medicine. Turning the base of the Respimat device until it clicks will release the medicine into the inhaler chamber. You will need 2 puffs to get a full dose.
The Spiriva Respimat inhaler will lock and cannot be turned after 30 doses (or 60 puffs) have been used. An indicator on the side of the inhaler will show when there are 14 puffs (or 7 days) of medicine left in the cartridge.
To be sure this medicine is helping your condition, your lung function will need to be tested on a regular basis.
Use this medicine regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.
Store at room temperature away from moisture and heat. Do not freeze. Do not store capsules in the HandiHaler device.
Spiriva dosing information
Usual Adult Dose for Chronic Obstructive Pulmonary Disease - Maintenance:
Tiotropium inhalation powder, hard capsule:
-18 mcg (2 inhalations) once a day using the HandiHaler device
Tiotropium, solution for inhalation:
-5 mcg (2 inhalations) once a day
Uses: Long-term maintenance treatment of bronchospasm associated with chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema; to reduce exacerbations in COPD patients
See also: Dosage Information (in more detail)
What happens if I miss a dose?
Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.
Do not use more than 2 inhalations in a 24-hour period.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Overdose symptoms may include dry mouth, eye redness, constipation, stomach pain, and confusion or drowsiness.
What should I avoid while using Spiriva?
Avoid getting the powder from a Spiriva capsule in your eyes. If this does happen, call your doctor.
This medicine may cause dizziness or blurred vision and may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert and able to see clearly.
Using Spiriva with other drugs that cause blurred vision, constipation, or difficult urination can worsen these effects. Avoid using cold or allergy medicine, over-the-counter sleep medicine, a muscle relaxer, or medicine to prevent nausea or motion sickness.
Spiriva side effects
Get emergency medical help if you have signs of an allergic reaction to Spiriva: hives, itching; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
wheezing, choking, or other breathing problems after using this medicine;
blurred vision, eye pain or redness, seeing halos around lights;
sores or white patches on your mouth, lips, or tongue;
pain or burning when you urinate; or
little or no urinating.
Common Spiriva side effects may include:
constipation, painful urination;
chest pain; or
cold symptoms such as stuffy or runny nose, sinus pain, sore throat.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
What other drugs will affect Spiriva?
Other drugs may interact with tiotropium inhalation, including prescription and over-the-counter medicines, eye drops, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.
More about Spiriva (tiotropium)
- Other brands: Spiriva Respimat
Related treatment guides
Where can I get more information?
- Your pharmacist can provide more information about Spiriva.
- Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.
- Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
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