Skip to Content

Vimpat Side Effects

Generic Name: lacosamide

Note: This document contains side effect information about lacosamide. Some of the dosage forms listed on this page may not apply to the brand name Vimpat.

For the Consumer

Applies to lacosamide: oral solution, oral tablet

Other dosage forms:

Along with its needed effects, lacosamide (the active ingredient contained in Vimpat) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking lacosamide:

More Common

  • Dizziness
  • false or unusual sense of well-being
  • shakiness and unsteady walk
  • sleepiness or unusual drowsiness
  • trembling or shaking of the hands or feet
  • unsteadiness, trembling, or other problems with muscle control or coordination

Less Common

  • Being forgetful
  • discouragement
  • feeling sad or empty
  • irritability
  • itching skin
  • lack of appetite
  • loss of balance control
  • loss of interest or pleasure
  • mood or mental changes
  • tearing of the skin
  • tiredness
  • trouble concentrating
  • trouble with sleeping
  • trouble with walking

Incidence Not Known

  • Abnormal or decreased touch sensation
  • black, tarry stools
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • changes in patterns and rhythms of speech
  • chills
  • continuing ringing or buzzing or other unexplained noise in the ears
  • cough
  • fast, irregular, pounding, or racing heartbeat or pulse
  • feeling drunk
  • fever
  • hearing loss
  • lower back or side pain
  • painful or difficult urination
  • pale skin
  • slurred speech
  • sore throat
  • trouble performing routine tasks
  • trouble with balance
  • trouble with speaking
  • troubled breathing with exertion
  • ulcers, sores, or white spots in the mouth
  • unusual bleeding or bruising
  • unusual tiredness or weakness

Some side effects of lacosamide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More Common

Less Common

  • Diarrhea
  • feeling of constant movement of self or surroundings
  • lack or loss of strength
  • sensation of spinning
  • uncontrolled eye movements

Incidence Not Known

For Healthcare Professionals

Applies to lacosamide: intravenous solution, oral solution, oral tablet

Nervous system

Very common (10% or more): Dizziness (up to 60%), headache (up to 13%), ataxia (up to 15%)

Common (1% to 10%): Somnolence, tremor, balance disorder, nystagmus, memory impairment, coordination abnormal, cognitive disorder, somnolence, tremor, dysarthria, disturbance in attention, paresthesia

Frequency not reported: Oral hypoesthesia, pyrexia

Postmarketing reports: Hypoesthesia, cerebellar syndrome[Ref]

Gastrointestinal

Very common (10% or more): Nausea (up to 24%), vomiting (up to 16%)

Common (1% to 10%): Diarrhea, constipation, flatulence, dyspepsia, dry mouth[Ref]

Ocular

Very common (10% or more): Diplopia (up to 16%), blurred vision (up to 16%)[Ref]

Other

Very common (10% or more): Fatigue (up to 15%)

Common (1% to 10%): Asthenia, vertigo, gait disturbance

Frequency not reported: Tinnitus, fall[Ref]

Local

Common (1% to 10%): Injection site pain or discomfort

Uncommon (0.1% to 1%): Irritation, erythema[Ref]

Psychiatric

Common (1% to 10%): Depression, confusional state, insomnia

Uncommon (0.1% to 1%): Aggression, agitation, euphoric mood, suicide attempt, suicidal ideation, hallucination

Frequency not reported: Irritability, feeling drunk

Postmarketing reports: Psychotic disorder[Ref]

Dermatologic

Common (1% to 10%): Pruritus, rash

Uncommon (0.1% to 1%): Angioedema, urticaria

Frequency not reported: Neutropenia, anemia

Postmarketing reports: Stevens-Johnson syndrome, toxic epidermal necrolysis[Ref]

Cardiovascular

Very common (10% or more): Chest pain (up to 12%)

Uncommon (0.1% to 1%): Atrioventricular block, bradycardia, atrial fibrillation, atrial flutter

Frequency not reported: Palpitations[Ref]

Musculoskeletal

Common (1% to 10%): Muscle spasms

Frequency not reported: Connective tissue disorders[Ref]

Hematologic

Frequency not reported: Neutropenia, anemia

Postmarketing reports: Agranulocytosis[Ref]

Hepatic

Uncommon (0.1% to 1%): Lever function test abnormal

Frequency not reported: Hepatitis[Ref]

Hypersensitivity

Uncommon (0.1% to 1%): Hypersensitivity

Frequency not reported: Multiorgan hypersensitivity reactions (also known as Drug Reaction with Eosinophilia and Systemic Symptoms, or DRESS)[Ref]

References

1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. Cerner Multum, Inc. "Australian Product Information." O 0

3. "Product Information. Vimpat (lacosamide)." UCB Pharma Inc, Smyrna, GA.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Hide