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Vimpat Side Effects

Generic Name: lacosamide

Note: This document contains side effect information about lacosamide. Some of the dosage forms listed on this page may not apply to the brand name Vimpat.

For the Consumer

Applies to lacosamide: oral solution, oral tablet

Other dosage forms:

Along with its needed effects, lacosamide (the active ingredient contained in Vimpat) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking lacosamide:

More common
  • Dizziness
  • false or unusual sense of well-being
  • shakiness and unsteady walk
  • sleepiness or unusual drowsiness
  • trembling or shaking of the hands or feet
  • unsteadiness, trembling, or other problems with muscle control or coordination
Less common
  • Being forgetful
  • discouragement
  • feeling sad or empty
  • irritability
  • itching skin
  • lack of appetite
  • loss of balance control
  • loss of interest or pleasure
  • mood or mental changes
  • tearing of the skin
  • tiredness
  • trouble concentrating
  • trouble with sleeping
  • trouble with walking
Incidence not known
  • Abnormal or decreased touch sensation
  • black, tarry stools
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • changes in patterns and rhythms of speech
  • chills
  • continuing ringing or buzzing or other unexplained noise in the ears
  • cough
  • fast, irregular, pounding, or racing heartbeat or pulse
  • feeling drunk
  • fever
  • hearing loss
  • lower back or side pain
  • painful or difficult urination
  • pale skin
  • slurred speech
  • sore throat
  • trouble performing routine tasks
  • trouble with balance
  • trouble with speaking
  • troubled breathing with exertion
  • ulcers, sores, or white spots in the mouth
  • unusual bleeding or bruising
  • unusual tiredness or weakness

Some side effects of lacosamide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Blurred vision
  • double vision
  • headache
  • nausea
  • seeing double
  • vomiting
Less common
  • Diarrhea
  • feeling of constant movement of self or surroundings
  • lack or loss of strength
  • sensation of spinning
  • uncontrolled eye movements
Incidence not known
  • Acid or sour stomach
  • belching
  • difficulty having a bowel movement (stool)
  • dry mouth
  • heartburn
  • indigestion
  • muscle spasms
  • stomach discomfort, upset, or pain

For Healthcare Professionals

Applies to lacosamide: intravenous solution, oral solution, oral tablet

Nervous system

Very common (10% or more): Dizziness (up to 60%), headache (up to 13%), ataxia (up to 15%)
Common (1% to 10%): Somnolence, tremor, balance disorder, nystagmus, memory impairment, coordination abnormal, cognitive disorder, somnolence, tremor, dysarthria, disturbance in attention, paresthesia
Frequency not reported: Oral hypoesthesia, pyrexia
Postmarketing reports: Hypoesthesia, cerebellar syndrome[Ref]

Gastrointestinal

Very common (10% or more): Nausea (up to 24%), vomiting (up to 16%)
Common (1% to 10%): Diarrhea, constipation, flatulence, dyspepsia, dry mouth[Ref]

Ocular

Very common (10% or more): Diplopia (up to 16%), blurred vision (up to 16%)[Ref]

Other

Very common (10% or more): Fatigue (up to 15%)
Common (1% to 10%): Asthenia, vertigo
Frequency not reported: Tinnitus, fall[Ref]

Local

Common (1% to 10%): Injection site pain or discomfort
Uncommon (0.1% to 1%): Irritation, erythema[Ref]

Psychiatric

Common (1% to 10%): Depression, confusional state, insomnia
Uncommon (0.1% to 1%): Aggression, agitation, euphoric mood, suicide attempt, suicidal ideation, hallucination
Frequency not reported: Irritability, feeling drunk
Postmarketing reports: Psychotic disorder[Ref]

Dermatologic

Common (1% to 10%): Pruritus, rash
Uncommon (0.1% to 1%): Angioedema, urticaria
Frequency not reported: Neutropenia, anemia
Postmarketing reports: Stevens-Johnson syndrome, toxic epidermal necrolysis[Ref]

Cardiovascular

Very common (10% or more): Chest pain (up to 12%)
Uncommon (0.1% to 1%): Atrioventricular block, bradycardia, atrial fibrillation, atrial flutter
Frequency not reported: Palpitations[Ref]

Musculoskeletal

Common (1% to 10%): Muscle spasms
Frequency not reported: Connective tissue disorders[Ref]

Hematologic

Frequency not reported: Neutropenia, anemia
Postmarketing reports: Agranulocytosis[Ref]

Hepatic

Uncommon (0.1% to 1%): Lever function test abnormal[Ref]

Hypersensitivity

Uncommon (0.1% to 1%): Hypersensitivity
Frequency not reported: Multiorgan hypersensitivity reactions (also known as Drug Reaction with Eosinophilia and Systemic Symptoms, or DRESS)[Ref]

References

1. Cerner Multum, Inc. "Australian Product Information." O 0

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

3. "Product Information. Vimpat (lacosamide)." UCB Pharma Inc, Smyrna, GA.

Some side effects of Vimpat may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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