Skip to Content

Vimpat

Generic Name: lacosamide (la KOE sa mide)
Brand Names: Vimpat

What is Vimpat?

Vimpat (lacosamide) is an anti-epileptic drug, also called an anticonvulsant.

Vimpat is used together with other medications to treat partial-onset seizures in adults and children with epilepsy who are at least 4 years old.

Vimpat may also be used for purposes not listed in this medication guide.

Important information

Do not stop using Vimpat suddenly or you may have increased seizures.

Some young people have thoughts about suicide while taking Vimpat. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor.

You may feel faint while taking Vimpat. Call your doctor right away if you have fast or pounding heartbeats, shortness of breath, and sudden dizziness.

Before taking this medicine

You should not use Vimpat if you are allergic to lacosamide.

To make sure this medicine is safe for you, tell your doctor if you have ever had:

  • heart disease;

  • kidney disease;

  • liver disease;

  • depression, suicidal thoughts or actions;

  • drug or alcohol addiction;

  • nerve problems caused by diabetes; or

  • phenylketonuria/PKU (Vimpat oral solution may contain phenylalanine).

Some people have thoughts about suicide while taking lacosamide. Your doctor will need to check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.

Call your doctor if you have new or worsening depression or suicidal thoughts during the first several months of treatment, or whenever your dose is changed.

Follow your doctor's instructions about taking seizure medication if you are pregnant. Seizure control is very important during pregnancy, and having a seizure could harm both mother and baby. Do not start or stop taking Vimpat without your doctor's advice, and tell your doctor right away if you become pregnant.

If you are pregnant, your name may be listed on a pregnancy registry. This is to track the outcome of the pregnancy and to evaluate any effects of lacosamide on the baby.

It is not known whether lacosamide passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.

Vimpat is not approved for use by anyone younger than 4 years old.

How should I take Vimpat?

Take Vimpat exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Vimpat can be taken with or without food.

Measure liquid medicine with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.

Contact your doctor if your seizures get worse or you have them more often while taking Vimpat.

Wear a medical alert tag or carry an ID card stating that you take Vimpat. Any medical care provider who treats you should know that you take seizure medication.

Use Vimpat regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.

Do not stop using Vimpat suddenly, even if you feel fine. Stopping suddenly may cause increased seizures. Follow your doctor's instructions about tapering your dose.

Store at room temperature away from moisture and heat. Do not freeze the liquid form of Vimpat.

Keep track of your medicine. Lacosamide is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.

Vimpat dosing information

Usual Adult Dose for Seizures:

MONOTHERAPY:
-Initial dose: 100 mg orally or IV twice a day (200 mg per day)
-Titration: Increase the dose by 50 mg twice a day (100 mg per day) every 7 days
-Maintenance dose: 150 to 200 mg orally or IV twice a day (300 to 400 mg per day)
-Alternate dosing: Initiate therapy with a single loading dose of 200 mg orally or IV, followed 12 hours later by 100 mg orally or IV twice a day for 7 days; based on individual response and tolerability, the dose can be increased by 50 mg twice a day (100 mg per day) every 7 days, as needed, up to a maintenance dose of 150 to 200 mg orally or IV twice a day (the loading dose should be administered with medical supervision because of the increased incidence of CNS adverse reactions)

ADJUNCTIVE THERAPY:
-Initial dose: 50 mg orally or IV twice a day (100 mg per day)
-Titration: Increase the dose by 50 mg twice a day (100 mg per day) every 7 days
-Maintenance dose: 100 to 200 mg orally or IV twice a day (200 to 400 mg per day)
-Alternate dosing: Initiate therapy with a single loading dose of 200 mg orally or IV, followed 12 hours later by 100 mg orally or IV twice a day for 7 days; based on individual response and tolerability, the dose can be increased by 50 mg twice a day, as needed, up to the maximum maintenance dose of 200 mg orally or IV twice a day (the loading dose should be administered with medical supervision because of the increased incidence of CNS adverse reactions)

Comments:
-Therapy can be initiated with either oral or IV administration.
-The oral formulation may be taken with or without food.
-The IV formulation is intended as an alternative when oral administration is temporarily not feasible.
-The IV formulation can be administered in the same dosing regimens used for oral dosing, including the loading dose.
-The IV formulation should be infused over a period of 15 to 60 minutes; IV infusion over 30 to 60 minutes is preferable, and should be used when a 15-minute administration is not required.

Use: As monotherapy or adjunctive therapy for partial-onset seizures in patients 4 years of age and older

Dosage Information (comprehensive)

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking Vimpat?

Vimpat may cause blurred vision or impair your balance, thinking, or reactions. Be careful if you drive or do anything that requires you to be alert and able to see clearly.

Vimpat side effects

Get emergency medical help if you have signs of an allergic reaction to Vimpat: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include: skin rash, fever, swollen glands, flu-like symptoms, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes. This reaction may occur several weeks after you began using Vimpat.

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, depression, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), or have thoughts about suicide or hurting yourself.

Call your doctor at once if you have:

  • a light-headed feeling, like you might pass out;

  • shortness of breath; or

  • fast, slow, or pounding heartbeats, fluttering in your chest.

Common Vimpat side effects may include:

  • headache, dizziness;

  • double vision; or

  • nausea.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1 800 FDA 1088.

Side Effects (complete list)

What other drugs will affect Vimpat?

Other drugs may interact with lacosamide, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Where can I get more information?

  • Your pharmacist can provide more information about Vimpat.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Vimpat only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2017 Cerner Multum, Inc. Version: 5.01.

Date modified: December 03, 2017
Last reviewed: November 11, 2017

Hide