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Vimpat

Generic Name: lacosamide (la KOE sa mide)
Brand Names: Vimpat

Medically reviewed on May 7, 2018

What is Vimpat?

Vimpat (lacosamide) is an anti-epileptic drug, also called an anticonvulsant.

Vimpat is used together with other medications to treat partial-onset seizures in adults and children with epilepsy who are at least 4 years old.

Vimpat may also be used for purposes not listed in this medication guide.

Important information

Do not stop using Vimpat suddenly or you may have increased seizures.

Some people have thoughts about suicide while taking Vimpat. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor.

You may feel faint while taking Vimpat. Call your doctor right away if you have fast or pounding heartbeats, shortness of breath, and sudden dizziness.

Before taking this medicine

You should not use Vimpat if you are allergic to lacosamide.

To make sure this medicine is safe for you, tell your doctor if you have ever had:

  • heart disease;

  • kidney disease;

  • liver disease;

  • depression, suicidal thoughts or actions;

  • drug or alcohol addiction;

  • nerve problems caused by diabetes; or

  • phenylketonuria/PKU (Vimpat oral solution may contain phenylalanine).

Some people have thoughts about suicide while taking lacosamide. Your doctor will need to check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.

Call your doctor if you have new or worsening depression or suicidal thoughts during the first several months of treatment, or whenever your dose is changed.

Follow your doctor's instructions about taking seizure medication if you are pregnant. Seizure control is very important during pregnancy, and having a seizure could harm both mother and baby. Do not start or stop taking Vimpat without your doctor's advice, and tell your doctor right away if you become pregnant.

If you are pregnant, your name may be listed on a pregnancy registry. This is to track the outcome of the pregnancy and to evaluate any effects of lacosamide on the baby.

It is not known whether lacosamide passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.

Vimpat is not approved for use by anyone younger than 4 years old.

How should I take Vimpat?

Take Vimpat exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Vimpat tablets or oral solution can be taken with or without food.

Measure the liquid medicine carefully. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).

Vimpat injection is given as an infusion into a vein. A healthcare provider will give you this injection if you are unable to take the medicine by mouth.

Contact your doctor if your seizures get worse or you have them more often while taking Vimpat.

Wear a medical alert tag or carry an ID card stating that you take Vimpat. Any medical care provider who treats you should know that you take seizure medication.

Use Vimpat regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.

Do not stop using Vimpat suddenly, even if you feel fine. Stopping suddenly may cause increased seizures. Follow your doctor's instructions about tapering your dose.

Follow your doctor's instructions about tapering your dose.

In case of emergency, wear or carry medical identification to let others know you use seizure medication.

Store at room temperature away from moisture and heat. Do not freeze the liquid form of Vimpat. Throw away any liquid not used within 7 weeks after opening the bottle.

Keep track of your medicine. Lacosamide is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.

Vimpat dosing information

Usual Adult Dose for Seizures:

MONOTHERAPY:
-Initial dose: 100 mg orally or IV twice a day (200 mg per day)
-Titration: Increase the dose by 50 mg twice a day (100 mg per day) every 7 days
-Maintenance dose: 150 to 200 mg orally or IV twice a day (300 to 400 mg per day)
-Alternate dosing: Initiate therapy with a single loading dose of 200 mg orally or IV, followed 12 hours later by 100 mg orally or IV twice a day for 7 days; based on individual response and tolerability, the dose can be increased by 50 mg twice a day (100 mg per day) every 7 days, as needed, up to a maintenance dose of 150 to 200 mg orally or IV twice a day (the loading dose should be administered with medical supervision because of the increased incidence of CNS adverse reactions)

ADJUNCTIVE THERAPY:
-Initial dose: 50 mg orally or IV twice a day (100 mg per day)
-Titration: Increase the dose by 50 mg twice a day (100 mg per day) every 7 days
-Maintenance dose: 100 to 200 mg orally or IV twice a day (200 to 400 mg per day)
-Alternate dosing: Initiate therapy with a single loading dose of 200 mg orally or IV, followed 12 hours later by 100 mg orally or IV twice a day for 7 days; based on individual response and tolerability, the dose can be increased by 50 mg twice a day, as needed, up to the maximum maintenance dose of 200 mg orally or IV twice a day (the loading dose should be administered with medical supervision because of the increased incidence of CNS adverse reactions)

Comments:
-Therapy can be initiated with either oral or IV administration.
-The oral formulation may be taken with or without food.
-The IV formulation is intended as an alternative when oral administration is temporarily not feasible.
-The IV formulation can be administered in the same dosing regimens used for oral dosing, including the loading dose.
-The IV formulation should be infused over a period of 15 to 60 minutes; IV infusion over 30 to 60 minutes is preferable, and should be used when a 15-minute administration is not required.

Use: As monotherapy or adjunctive therapy for partial-onset seizures in patients 4 years of age and older

See also: Dosage Information (in more detail)

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

Get your prescription refilled before you run out of medicine completely.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking Vimpat?

Vimpat may cause dizziness or blurred vision and may impair your reactions. Avoid driving or hazardous activity until you know how this medicine will affect you.

Vimpat side effects

Get emergency medical help if you have signs of an allergic reaction to Vimpat: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include: skin rash, fever, swollen glands, flu-like symptoms, muscle aches, swelling in your legs, tiredness, dark urine, or yellowing of your skin or eyes.

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, depression, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), or have thoughts about suicide or hurting yourself.

Call your doctor at once if you have:

  • a light-headed feeling, like you might pass out;

  • severe dizziness;

  • problems with balance or muscle movement;

  • shortness of breath; or

  • fast, slow, or pounding heartbeats, fluttering in your chest.

Common Vimpat side effects may include:

  • headache, dizziness;

  • double vision; or

  • nausea.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1 800 FDA 1088.

See also: Side effects (in more detail)

What other drugs will affect Vimpat?

Other drugs may interact with lacosamide, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Vimpat only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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