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Vaseretic Side Effects

Generic name: enalapril / hydrochlorothiazide

Medically reviewed by Last updated on Mar 30, 2022.

Note: This document contains side effect information about enalapril / hydrochlorothiazide. Some of the dosage forms listed on this page may not apply to the brand name Vaseretic.

In Summary

Common side effects of Vaseretic include: increased blood urea nitrogen and increased serum creatinine. Other side effects include: dizziness and headache. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to enalapril / hydrochlorothiazide: oral tablet


Oral route (Tablet)

Discontinue enalapril maleate/hydrochlorothiazide as soon as possible when pregnancy is detected, since fetal toxicity, including injury and death to the developing fetus, can be caused by drugs that act directly on the renin-angiotensin system.

Side effects requiring immediate medical attention

Along with its needed effects, enalapril / hydrochlorothiazide may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking enalapril / hydrochlorothiazide:

Less common

  • Blurred vision
  • chest pain, discomfort, or tightness
  • chills
  • cold sweats
  • coma
  • confusion
  • decreased urine output
  • diarrhea
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • drowsiness
  • dry mouth
  • fainting
  • fast, slow, or irregular heartbeat
  • headache
  • increased thirst
  • irritability
  • large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, sex organs
  • loss of appetite
  • lower back or side pain
  • muscle pain or cramps
  • nausea or vomiting
  • numbness or tingling in the hands, feet, or lips
  • rapid breathing
  • seizures
  • sunken eyes
  • sweating
  • swelling of the face, ankles, or hands
  • thirst
  • trouble breathing
  • unusual tiredness or weakness
  • weak pulse
  • wrinkled skin


  • Persistent non-healing sore
  • pink growth
  • reddish patch or irritated area
  • shiny bump
  • white, yellow or waxy scar-like area

Side effects not requiring immediate medical attention

Some side effects of enalapril / hydrochlorothiazide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Ankle, knee, or great toe joint pain
  • cough
  • decreased interest in sexual intercourse
  • difficulty in moving
  • inability to have or keep an erection
  • itching skin
  • joint stiffness or swelling
  • lack or loss of strength
  • loss in sexual ability, desire, drive, or performance
  • pain in the joints
  • trouble sleeping
  • unable to sleep

For Healthcare Professionals

Applies to enalapril / hydrochlorothiazide: oral tablet


The most common adverse reactions were dizziness, headache, fatigue, and cough.[Ref]

Nervous system

Common (1% to 10%): Dizziness, headache, syncope

Frequency not reported: Paresthesia, somnolence, vertigo, tinnitus


Postmarketing reports: Cerebrovascular accident, ataxia, peripheral neuropathy, paresthesia, dysesthesia, taste alteration, anosmia[Ref]


Common (1% to 10%): Fatigue, asthenia, orthostatic effects

Frequency not reported: Chest pain


Postmarketing reports: Gynecomastia


Frequency not reported: Weakness, fever[Ref]


Common (1% to 10%): Cough

Frequency not reported: Dyspnea


Postmarketing reports: Pulmonary embolism and infarction, pulmonary edema


Frequency not reported: Respiratory distress, pneumonitis, pulmonary edema[Ref]


Common (1% to 10%): Muscle cramps

Frequency not reported: Back pain, arthralgia


Postmarketing reports: Flank pain


Frequency not reported: Muscle spasm[Ref]


Common (1% to 10%): Nausea, diarrhea

Frequency not reported: Abdominal pain, vomiting, dyspepsia, constipation, flatulence, dry mouth


Postmarketing reports: Ileus, pancreatitis, melena, glossitis, stomatitis, dry mouth


Frequency not reported: Pancreatitis, sialadenitis, cramping, gastric irritation[Ref]


Common (1% to 10%): Impotence

Frequency not reported: Urinary tract infection


Postmarketing reports: Oliguria[Ref]


Common (1% to 10%): Orthostatic hypotension

Uncommon (0.1% to 1%): Hypotension

Frequency not reported: Palpitation, tachycardia


Postmarketing reports: Cardiac arrest, myocardial infarction, rhythm disturbances, atrial tachycardia and bradycardia, atrial fibrillation, hypotension, angina pectoris, Raynaud's phenomenon, flushing


Frequency not reported: Vasculitis[Ref]


Uncommon (0.1% to 1%): BUN increased, serum creatinine increased


Postmarketing reports: Renal failure, renal dysfunction, pulmonary infiltrates, eosinophilic pneumonitis, bronchospasm, pneumonia, bronchitis, rhinorrhea, sore throat and hoarseness, asthma, upper respiratory infection


Frequency not reported: Renal failure, renal dysfunction, interstitial nephritis[Ref]


Frequency not reported: Pruritus, rash, diaphoresis, angioedema


Postmarketing reports: Exfoliative dermatitis, toxic epidermal necrolysis, Stevens-Johnson syndrome, herpes zoster, erythema multiforme, urticaria, pemphigus, alopecia, photosensitivity


Frequency not reported: Purpura, photosensitivity, urticaria, cutaneous vasculitis, erythema multiforme, Stevens-Johnson syndrome, exfoliative dermatitis, toxic epidermal necrolysis, alopecia[Ref]


Frequency not reported: Insomnia, nervousness, libido decreased


Postmarketing reports: Depression, confusion, dream abnormality


Frequency not reported: Restlessness[Ref]


Frequency not reported: Hemoglobin decreased, hematocrit decreased


Postmarketing reports: Neutropenia, thrombocytopenia, bone marrow depression, hemolytic anemia


Frequency not reported: Aplastic anemia, agranulocytosis, leukopenia, hemolytic anemia, thrombocytopenia[Ref]


Frequency not reported: Liver enzymes increased, serum bilirubin increased


Postmarketing reports: Hepatic failure, hepatitis


Frequency not reported: Intrahepatic cholestatic jaundice[Ref]


Frequency not reported: Gout

Postmarketing reports: Anorexia


Frequency not reported: Anorexia[Ref]



Postmarketing reports: Blurred vision, conjunctivitis, dry eyes, tearing


Frequency not reported: Transient blurred vision, xanthopsia[Ref]



Postmarketing reports: Anaphylactoid reactions


Frequency not reported: Anaphylactic reactions[Ref]


1. "Product Information. Vaseretic (enalapril-hydrochlorothiazide)." Merck & Co, Inc, West Point, PA.

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

3. Cerner Multum, Inc. "Australian Product Information." O 0

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.