Vaseretic Side Effects

Generic name: enalapril / hydrochlorothiazide

Medically reviewed by Drugs.com. Last updated on May 18, 2024.

Note: This document provides detailed information about Vaseretic Side Effects associated with enalapril / hydrochlorothiazide. Some dosage forms listed on this page may not apply specifically to the brand name Vaseretic.

Applies to enalapril / hydrochlorothiazide: oral tablet.

Precautions

It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly. Blood and urine tests may be needed to check for unwanted effects.

Using this medicine while you are pregnant can harm your unborn baby, especially in your second or third trimester. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using this medicine, tell your doctor right away. You may need to stop using this medicine.

You should not use this medicine together with sacubitril. Do not use this medicine and sacubitril/valsartan (Entresto®) within 36 hours of each other.

This medicine may cause a serious type of allergic reaction, including anaphylaxis. This can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash, itching, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth while you are using this medicine.

Call your doctor right away if you have severe stomach pain (with or without nausea or vomiting). This could be a symptom of a condition called intestinal angioedema.

Dizziness, lightheadedness, or fainting may also occur, especially when you get up suddenly from a lying or sitting position or if you have been taking a diuretic (water pill). . If you feel dizzy, lie down so you do not faint. Then sit for a few moments before standing to prevent the dizziness from returning. If you faint, stop using this medicine and call your doctor right away.

Check with your doctor right away if you become sick while taking this medicine, especially with severe or continuing nausea, vomiting, or diarrhea. These conditions may cause you to lose too much water or salt and may lead to low blood pressure. You can also lose water by sweating, so drink plenty of water during exercise or in hot weather.

This medicine may affect blood sugar levels. If you notice a change in the results of your blood or urine sugar tests, or if you have any questions, check with your doctor.

Check with your doctor if you have a fever, chills, or sore throat. These could be symptoms of an infection resulting from low white blood cells.

Check with your doctor right away if you have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, or yellow eyes or skin. These could be symptoms of a serious liver problem.

Check with your doctor immediately if blurred vision, difficulty in reading, eye pain, or any other change in vision occurs during or after treatment. This could be a sign of a serious eye problem. Your doctor may want an eye doctor (ophthalmologist) to check your eyes.

Check with your doctor right away if you have bloody urine, a decrease in frequency or amount of urine, an increase in blood pressure, increased thirst, loss of appetite, lower back or side pain, nausea, swelling of the face, fingers, or lower legs, trouble breathing, unusual tiredness or weakness, vomiting, or weight gain. These could be symptoms of a serious kidney problem.

Hyperkalemia (high potassium in the blood) may occur while you are using this medicine. Check with your doctor right away if you have stomach pain, confusion, irregular heartbeat, nausea or vomiting, nervousness, numbness or tingling in the hands, feet, or lips, trouble breathing, or weakness or heaviness of the legs. Do not use medicines, supplements, or salt substitutes that contain potassium unless you have discussed this with your doctor.

This medicine may increase your risk of getting skin cancer (eg, non-melanoma skin cancer). Avoid sun exposure. Use a sunscreen when you are outdoors. Avoid sunlamps and tanning beds. Talk to your doctor if you have concerns about this risk.

Make sure any doctor or dentist who treats you knows that you are using this medicine. You may need to stop using this medicine several days before having surgery.

This medicine may be less effective in black patients. Black patients also have an increased risk of swelling of the hands, arms, face, mouth, or throat. Talk with your doctor if you have concerns about this.

Alcohol, narcotic pain relievers, or sleeping pills may cause you to feel more lightheaded, dizzy, or faint when used with this medicine. Tell your doctor if you are drinking alcohol or using pain relievers or sleeping pills.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines for appetite control, asthma, colds, cough, hay fever, or sinus problems, and herbal or vitamin supplements.

Serious side effects of Vaseretic

Along with its needed effects, enalapril / hydrochlorothiazide may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking enalapril / hydrochlorothiazide:

Other side effects of Vaseretic

Some side effects of enalapril / hydrochlorothiazide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For healthcare professionals

Applies to enalapril / hydrochlorothiazide: oral tablet.

General adverse events

The most common adverse reactions were dizziness, headache, fatigue, and cough.^[Ref]

Nervous system

• Common (1% to 10%): Dizziness, headache, syncope
• Frequency not reported: Paresthesia, somnolence, vertigo, tinnitus

Enalapril:

• Postmarketing reports: Cerebrovascular accident, ataxia, peripheral neuropathy, paresthesia, dysesthesia, taste alteration, anosmia^[Ref]

Other

• Common (1% to 10%): Fatigue, asthenia, orthostatic effects
• Frequency not reported: Chest pain

Enalapril:

• Postmarketing reports: Gynecomastia

Hydrochlorothiazide:

• Frequency not reported: Weakness, fever^[Ref]

Respiratory

• Common (1% to 10%): Cough
• Frequency not reported: Dyspnea

Enalapril:

• Postmarketing reports: Pulmonary embolism and infarction, pulmonary edema

Hydrochlorothiazide:

• Frequency not reported: Respiratory distress, pneumonitis, pulmonary edema^[Ref]

Musculoskeletal

• Common (1% to 10%): Muscle cramps
• Frequency not reported: Back pain, arthralgia

Enalapril:

• Postmarketing reports: Flank pain

Hydrochlorothiazide:

• Frequency not reported: Muscle spasm^[Ref]

Gastrointestinal

• Common (1% to 10%): Nausea, diarrhea
• Frequency not reported: Abdominal pain, vomiting, dyspepsia, constipation, flatulence, dry mouth

Enalapril:

• Postmarketing reports: Ileus, pancreatitis, melena, glossitis, stomatitis, dry mouth

Hydrochlorothiazide:

• Frequency not reported: Pancreatitis, sialadenitis, cramping, gastric irritation^[Ref]

Genitourinary

• Common (1% to 10%): Impotence
• Frequency not reported: Urinary tract infection

Enalapril:

• Postmarketing reports: Oliguria^[Ref]

Cardiovascular

• Common (1% to 10%): Orthostatic hypotension
• Uncommon (0.1% to 1%): Hypotension
• Frequency not reported: Palpitation, tachycardia

Enalapril:

• Postmarketing reports: Cardiac arrest, myocardial infarction, rhythm disturbances, atrial tachycardia and bradycardia, atrial fibrillation, hypotension, angina pectoris, Raynaud's phenomenon, flushing

Hydrochlorothiazide:

• Frequency not reported: Vasculitis^[Ref]

Renal

• Uncommon (0.1% to 1%): BUN increased, serum creatinine increased

Enalapril:

• Postmarketing reports: Renal failure, renal dysfunction, pulmonary infiltrates, eosinophilic pneumonitis, bronchospasm, pneumonia, bronchitis, rhinorrhea, sore throat and hoarseness, asthma, upper respiratory infection

Hydrochlorothiazide:

• Frequency not reported: Renal failure, renal dysfunction, interstitial nephritis^[Ref]

Dermatologic

• Frequency not reported: Pruritus, rash, diaphoresis, angioedema

Enalapril:

• Postmarketing reports: Exfoliative dermatitis, toxic epidermal necrolysis, Stevens-Johnson syndrome, herpes zoster, erythema multiforme, urticaria, pemphigus, alopecia, photosensitivity

Hydrochlorothiazide:

• Frequency not reported: Purpura, photosensitivity, urticaria, cutaneous vasculitis, erythema multiforme, Stevens-Johnson syndrome, exfoliative dermatitis, toxic epidermal necrolysis, alopecia^[Ref]

Psychiatric

• Frequency not reported: Insomnia, nervousness, libido decreased

Enalapril:

• Postmarketing reports: Depression, confusion, dream abnormality

Hydrochlorothiazide:

• Frequency not reported: Restlessness^[Ref]

Hematologic

• Frequency not reported: Hemoglobin decreased, hematocrit decreased

Enalapril:

• Postmarketing reports: Neutropenia, thrombocytopenia, bone marrow depression, hemolytic anemia

Hydrochlorothiazide:

• Frequency not reported: Aplastic anemia, agranulocytosis, leukopenia, hemolytic anemia, thrombocytopenia^[Ref]

Hepatic

• Frequency not reported: Liver enzymes increased, serum bilirubin increased

Enalapril:

• Postmarketing reports: Hepatic failure, hepatitis

Hydrochlorothiazide:

• Frequency not reported: Intrahepatic cholestatic jaundice^[Ref]

Metabolic

• Frequency not reported: Gout
• Postmarketing reports: Anorexia

Hydrochlorothiazide:

• Frequency not reported: Anorexia^[Ref]

Ocular

Enalapril:

• Postmarketing reports: Blurred vision, conjunctivitis, dry eyes, tearing

Hydrochlorothiazide:

• Frequency not reported: Transient blurred vision, xanthopsia^[Ref]

Immunologic

Enalapril:

• Postmarketing reports: Anaphylactoid reactions

Hydrochlorothiazide:

• Frequency not reported: Anaphylactic reactions^[Ref]

See also:

Further information

Vaseretic side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer