Vaseretic Side Effects

Generic name: enalapril / hydrochlorothiazide

Medically reviewed by Drugs.com. Last updated on Jun 5, 2024.

Note: This document provides detailed information about Vaseretic Side Effects associated with enalapril / hydrochlorothiazide. Some dosage forms listed on this page may not apply specifically to the brand name Vaseretic.

Applies to enalapril / hydrochlorothiazide: oral tablet.

Important warnings This medicine can cause some serious health issues

Oral route (tablet)

Discontinue enalapril maleate/hydrochlorothiazide as soon as possible when pregnancy is detected, since fetal toxicity, including injury and death to the developing fetus, can be caused by drugs that act directly on the renin-angiotensin system.

Serious side effects of Vaseretic

Along with its needed effects, enalapril / hydrochlorothiazide may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking enalapril / hydrochlorothiazide:

Less common side effects

• blurred vision
• chest pain, discomfort, or tightness
• chills
• cold sweats
• coma
• confusion
• decreased urine output
• diarrhea
• dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
• drowsiness
• dry mouth
• fainting
• fast, slow, or irregular heartbeat
• headache
• increased thirst
• irritability
• large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, sex organs
• loss of appetite
• lower back or side pain
• muscle pain or cramps
• nausea or vomiting
• numbness or tingling in the hands, feet, or lips
• rapid breathing
• seizures
• sunken eyes
• sweating
• swelling of the face, ankles, or hands
• thirst
• trouble breathing
• unusual tiredness or weakness
• weak pulse
• wrinkled skin

Rare side effects

• persistent non-healing sore
• pink growth
• reddish patch or irritated area
• shiny bump
• white, yellow or waxy scar-like area

Other side effects of Vaseretic

Some side effects of enalapril / hydrochlorothiazide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common side effects

• ankle, knee, or great toe joint pain
• cough
• decreased interest in sexual intercourse
• difficulty in moving
• inability to have or keep an erection
• itching skin
• joint stiffness or swelling
• lack or loss of strength
• loss in sexual ability, desire, drive, or performance
• pain in the joints
• trouble sleeping
• unable to sleep

For healthcare professionals

Applies to enalapril / hydrochlorothiazide: oral tablet.

General adverse events

The most common adverse reactions were dizziness, headache, fatigue, and cough.^[Ref]

Nervous system

• Common (1% to 10%): Dizziness, headache, syncope
• Frequency not reported: Paresthesia, somnolence, vertigo, tinnitus

Enalapril:

• Postmarketing reports: Cerebrovascular accident, ataxia, peripheral neuropathy, paresthesia, dysesthesia, taste alteration, anosmia^[Ref]

Other

• Common (1% to 10%): Fatigue, asthenia, orthostatic effects
• Frequency not reported: Chest pain

Enalapril:

• Postmarketing reports: Gynecomastia

Hydrochlorothiazide:

• Frequency not reported: Weakness, fever^[Ref]

Respiratory

• Common (1% to 10%): Cough
• Frequency not reported: Dyspnea

Enalapril:

• Postmarketing reports: Pulmonary embolism and infarction, pulmonary edema

Hydrochlorothiazide:

• Frequency not reported: Respiratory distress, pneumonitis, pulmonary edema^[Ref]

Musculoskeletal

• Common (1% to 10%): Muscle cramps
• Frequency not reported: Back pain, arthralgia

Enalapril:

• Postmarketing reports: Flank pain

Hydrochlorothiazide:

• Frequency not reported: Muscle spasm^[Ref]

Gastrointestinal

• Common (1% to 10%): Nausea, diarrhea
• Frequency not reported: Abdominal pain, vomiting, dyspepsia, constipation, flatulence, dry mouth

Enalapril:

• Postmarketing reports: Ileus, pancreatitis, melena, glossitis, stomatitis, dry mouth

Hydrochlorothiazide:

• Frequency not reported: Pancreatitis, sialadenitis, cramping, gastric irritation^[Ref]

Genitourinary

• Common (1% to 10%): Impotence
• Frequency not reported: Urinary tract infection

Enalapril:

• Postmarketing reports: Oliguria^[Ref]

Cardiovascular

• Common (1% to 10%): Orthostatic hypotension
• Uncommon (0.1% to 1%): Hypotension
• Frequency not reported: Palpitation, tachycardia

Enalapril:

• Postmarketing reports: Cardiac arrest, myocardial infarction, rhythm disturbances, atrial tachycardia and bradycardia, atrial fibrillation, hypotension, angina pectoris, Raynaud's phenomenon, flushing

Hydrochlorothiazide:

• Frequency not reported: Vasculitis^[Ref]

Renal

• Uncommon (0.1% to 1%): BUN increased, serum creatinine increased

Enalapril:

• Postmarketing reports: Renal failure, renal dysfunction, pulmonary infiltrates, eosinophilic pneumonitis, bronchospasm, pneumonia, bronchitis, rhinorrhea, sore throat and hoarseness, asthma, upper respiratory infection

Hydrochlorothiazide:

• Frequency not reported: Renal failure, renal dysfunction, interstitial nephritis^[Ref]

Dermatologic

• Frequency not reported: Pruritus, rash, diaphoresis, angioedema

Enalapril:

• Postmarketing reports: Exfoliative dermatitis, toxic epidermal necrolysis, Stevens-Johnson syndrome, herpes zoster, erythema multiforme, urticaria, pemphigus, alopecia, photosensitivity

Hydrochlorothiazide:

• Frequency not reported: Purpura, photosensitivity, urticaria, cutaneous vasculitis, erythema multiforme, Stevens-Johnson syndrome, exfoliative dermatitis, toxic epidermal necrolysis, alopecia^[Ref]

Psychiatric

• Frequency not reported: Insomnia, nervousness, libido decreased

Enalapril:

• Postmarketing reports: Depression, confusion, dream abnormality

Hydrochlorothiazide:

• Frequency not reported: Restlessness^[Ref]

Hematologic

• Frequency not reported: Hemoglobin decreased, hematocrit decreased

Enalapril:

• Postmarketing reports: Neutropenia, thrombocytopenia, bone marrow depression, hemolytic anemia

Hydrochlorothiazide:

• Frequency not reported: Aplastic anemia, agranulocytosis, leukopenia, hemolytic anemia, thrombocytopenia^[Ref]

Hepatic

• Frequency not reported: Liver enzymes increased, serum bilirubin increased

Enalapril:

• Postmarketing reports: Hepatic failure, hepatitis

Hydrochlorothiazide:

• Frequency not reported: Intrahepatic cholestatic jaundice^[Ref]

Metabolic

• Frequency not reported: Gout
• Postmarketing reports: Anorexia

Hydrochlorothiazide:

• Frequency not reported: Anorexia^[Ref]

Ocular

Enalapril:

• Postmarketing reports: Blurred vision, conjunctivitis, dry eyes, tearing

Hydrochlorothiazide:

• Frequency not reported: Transient blurred vision, xanthopsia^[Ref]

Immunologic

Enalapril:

• Postmarketing reports: Anaphylactoid reactions

Hydrochlorothiazide:

• Frequency not reported: Anaphylactic reactions^[Ref]

Further information

Vaseretic side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer