Hydrochlorothiazide and enalapril
Medically reviewed on October 2, 2017
What is hydrochlorothiazide and enalapril?
Hydrochlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention.
Enalapril is an ACE inhibitor. ACE stands for angiotensin converting enzyme. Enalapril lowers blood pressure and also relieves symptoms of fluid retention.
Hydrochlorothiazide and enalapril is a combination medicine used to treat hypertension (high blood pressure).
Hydrochlorothiazide and enalapril may also be used for purposes not listed in this medication guide.
Do not use if you are pregnant. If you become pregnant, stop taking this medicine and tell your doctor right away.
You should not use this medicine if you are unable to urinate, if you have ever had angioedema, or if you are allergic to sulfa drugs or any ACE inhibitor. Do not take hydrochlorothiazide and enalapril within 36 hours before or after taking medicine that contains sacubatril (such as Entresto).
Before taking this medicine
You should not use this medicine if you are allergic to hydrochlorothiazide or enalapril, or if:
you are unable to urinate;
you have a history of angioedema;
you recently took a heart medicine called sacubatril;
you are allergic to sulfa drugs; or
Do not take hydrochlorothiazide and enalapril within 36 hours before or after taking medicine that contains sacubatril (such as Entresto).
If you have diabetes, do not use hydrochlorothiazide and enalapril together with any medication that contains aliskiren (such as Tekturna or Tekamlo).
You may also need to avoid taking hydrochlorothiazide and enalapril with aliskiren if you have kidney disease.
To make sure hydrochlorothiazide and enalapril is safe for you, tell your doctor if you have:
kidney disease (or if you are on dialysis);
congestive heart failure;
an allergy to sulfa drugs or penicillin.
Do not use if you are pregnant. If you become pregnant, stop taking this medicine and tell your doctor right away. Enalapril can cause injury or death to the unborn baby if you take the medicine during your second or third trimester.
Hydrochlorothiazide and enalapril can pass into breast milk and may harm a nursing baby. You should not breast-feed while using this medicine.
How should I take hydrochlorothiazide and enalapril?
Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not use this medicine in larger or smaller amounts or for longer than recommended.
Call your doctor if you have ongoing vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while taking hydrochlorothiazide and enalapril. This can lead to very low blood pressure, electrolyte disorders, or kidney failure.
Your blood pressure will need to be checked often. Your blood and urine may also be tested if you have been vomiting or are dehydrated. Visit your doctor regularly.
Keep using this medicine as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.
If you need surgery, tell the surgeon ahead of time that you are using hydrochlorothiazide and enalapril.
Store at room temperature away from moisture, heat, and light. Keep the bottle tightly closed when not in use.
What happens if I miss a dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while taking hydrochlorothiazide and enalapril?
Drinking alcohol can further lower your blood pressure and may increase certain side effects of this medicine.
Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.
Do not use potassium supplements or salt substitutes while you are taking hydrochlorothiazide and enalapril, unless your doctor has told you to.
Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.
Hydrochlorothiazide and enalapril side effects
Get emergency medical help if you have signs of an allergic reaction (hives, severe stomach pain, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).
Call your doctor at once if you have:
a light-headed feeling, like you might pass out;
eye pain, vision problems;
pale skin, easy bruising or bleeding;
fever, chills, sore throat, mouth sores, trouble swallowing;
high potassium--nausea, weakness, tingly feeling, chest pain, irregular heartbeats, loss of movement;
low levels of sodium--headache, confusion, slurred speech, severe weakness, vomiting, loss of coordination, feeling unsteady.
Common side effects may include:
weakness, tired feeling;
nausea, diarrhea; or
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
Hydrochlorothiazide and enalapril dosing information
Usual Adult Dose for Hypertension:
Enalapril 5 to 10 mg-Hydrochlorothiazide 12.5 to 25 mg orally once a day
Maximum dose: Enalapril 20 mg-Hydrochlorothiazide 50 mg per day
Comments: Hydrochlorothiazide may be increased after 2 to 3 weeks.
Use: Treatment of hypertension only after failure to achieve the desired effect with monotherapy or the titrated components.
What other drugs will affect hydrochlorothiazide and enalapril?
Other drugs may interact with hydrochlorothiazide and enalapril, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Copyright 1996-2018 Cerner Multum, Inc. Version: 11.02.
More about enalapril/hydrochlorothiazide
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- Drug class: ACE inhibitors with thiazides
Other brands: Vaseretic