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Varubi IV Side Effects

Generic name: rolapitant

Medically reviewed by Drugs.com. Last updated on May 1, 2021.

Note: This document contains side effect information about rolapitant. Some of the dosage forms listed on this page may not apply to the brand name Varubi IV.

For the Consumer

Applies to rolapitant: oral tablet

Side effects requiring immediate medical attention

Along with its needed effects, rolapitant (the active ingredient contained in Varubi IV) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking rolapitant:

More common

  • Black, tarry stools
  • chills
  • cough
  • difficult, burning, or painful urination
  • fever
  • lower back or side pain
  • pale skin
  • sore throat
  • trouble breathing
  • ulcers, sores, or white spots in the mouth
  • unusual bleeding or bruising
  • unusual tiredness or weakness

Less common

  • Bladder pain
  • bloody or cloudy urine
  • frequent urge to urinate

Side effects not requiring immediate medical attention

Some side effects of rolapitant may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common

For Healthcare Professionals

Applies to rolapitant: intravenous emulsion, oral tablet

General

The most commonly reported side effects included decreased appetite, neutropenia, dizziness, and hiccups.[Ref]

Gastrointestinal

Common (1% to 10%): Abdominal pain, constipation, dyspepsia, stomatitis

Uncommon (0.1% to 1%): Abdominal distention, diarrhea, nausea, oral fungal infection

Rare (less than 0.1%): Abdominal discomfort, bowel habit change, dry mouth, gastroesophageal reflux disease, oral candidiasis, retching[Ref]

Nervous system

Common (1% to 10%): Dizziness, headache

Uncommon (0.1% to 1%): Disturbance in attention, dysgeusia, somnolence

Rare (less than 0.1%): Balance disorder, movement disorder, syncope[Ref]

Hematologic

Common (1% to 10%): Anemia, neutropenia

Rare (less than 0.1%): Decreased neutrophil count, increased international normalized ratio (INR), leukopenia, thrombocytopenia[Ref]

Metabolic

Common (1% to 10%): Decreased appetite

Rare (less than 0.1%): Dehydration, hypomagnesemia[Ref]

Respiratory

Common (1% to 10%): Hiccups[Ref]

Genitourinary

Common (1% to 10%): Urinary tract infection[Ref]

Musculoskeletal

Uncommon (0.1% to 1%): Myalgia

Rare (less than 0.1%): Arthralgia, back pain, muscular weakness, rhabdomyolysis[Ref]

Other

Uncommon (0.1% to 1%): Asthenia

Rare (less than 0.1%): Gait disturbance, hypoacusis, tinnitus[Ref]

Psychiatric

Uncommon (0.1% to 1%): Insomnia

Rare (less than 0.1%): Anxiety, bruxism[Ref]

Dermatologic

Rare (less than 0.1%): Acneiform dermatitis, alopecia, dry skin[Ref]

Hypersensitivity

Rare (less than 0.1%): Angioedema, hypersensitivity[Ref]

Cardiovascular

Rare (less than 0.1%): Hypertension, increased heart rate[Ref]

Immunologic

Rare (less than 0.1%): Candidiasis[Ref]

Ocular

Rare (less than 0.1%): Blurred vision[Ref]

More about Varubi IV (rolapitant)

Consumer resources

Other brands
Varubi

Professional resources

Related treatment guides

References

1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. "Product Information. Varubi (rolapitant)." Tesaro Inc., Waltham, MA.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.