Varubi IV Side Effects

Generic name: rolapitant

Medically reviewed by Drugs.com. Last updated on Feb 17, 2025.

Note: This document provides detailed information about Varubi IV Side Effects associated with rolapitant. Some dosage forms listed on this page may not apply specifically to the brand name Varubi IV.

Applies to rolapitant: oral tablet.

Serious side effects of Varubi IV

Along with its needed effects, rolapitant (the active ingredient contained in Varubi IV) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking rolapitant:

More common side effects

• black, tarry stools
• chills
• cough
• difficult, burning, or painful urination
• fever
• lower back or side pain
• pale skin
• sore throat
• trouble breathing
• ulcers, sores, or white spots in the mouth
• unusual bleeding or bruising
• unusual tiredness or weakness

Less common side effects

• bladder pain
• bloody or cloudy urine
• frequent urge to urinate

Other side effects of Varubi IV

Some side effects of rolapitant may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common side effects

• decreased appetite
• dizziness

Less common side effects

• acid or sour stomach
• belching
• heartburn
• hiccups
• indigestion
• stomach discomfort, upset, or pain

For healthcare professionals

Applies to rolapitant: intravenous emulsion, oral tablet.

General adverse events

The most commonly reported side effects included decreased appetite, neutropenia, dizziness, and hiccups.^[Ref]

Gastrointestinal

• Common (1% to 10%): Abdominal pain, constipation, dyspepsia, stomatitis
• Uncommon (0.1% to 1%): Abdominal distention, diarrhea, nausea, oral fungal infection
• Rare (less than 0.1%): Abdominal discomfort, bowel habit change, dry mouth, gastroesophageal reflux disease, oral candidiasis, retching^[Ref]

Nervous system

• Common (1% to 10%): Dizziness, headache
• Uncommon (0.1% to 1%): Disturbance in attention, dysgeusia, somnolence
• Rare (less than 0.1%): Balance disorder, movement disorder, syncope^[Ref]

Hematologic

• Common (1% to 10%): Anemia, neutropenia
• Rare (less than 0.1%): Decreased neutrophil count, increased international normalized ratio (INR), leukopenia, thrombocytopenia^[Ref]

Metabolic

• Common (1% to 10%): Decreased appetite
• Rare (less than 0.1%): Dehydration, hypomagnesemia^[Ref]

Respiratory

• Common (1% to 10%): Hiccups^[Ref]

Genitourinary

• Common (1% to 10%): Urinary tract infection^[Ref]

Musculoskeletal

• Uncommon (0.1% to 1%): Myalgia
• Rare (less than 0.1%): Arthralgia, back pain, muscular weakness, rhabdomyolysis^[Ref]

Other

• Uncommon (0.1% to 1%): Asthenia
• Rare (less than 0.1%): Gait disturbance, hypoacusis, tinnitus^[Ref]

Psychiatric

• Uncommon (0.1% to 1%): Insomnia
• Rare (less than 0.1%): Anxiety, bruxism^[Ref]

Dermatologic

• Rare (less than 0.1%): Acneiform dermatitis, alopecia, dry skin^[Ref]

Hypersensitivity

• Rare (less than 0.1%): Angioedema, hypersensitivity^[Ref]

Cardiovascular

• Rare (less than 0.1%): Hypertension, increased heart rate^[Ref]

Immunologic

• Rare (less than 0.1%): Candidiasis^[Ref]

Ocular

• Rare (less than 0.1%): Blurred vision^[Ref]

Further information

Varubi IV side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer