Skip to main content

Tymlos Side Effects

Generic name: abaloparatide

Medically reviewed by Last updated on Dec 4, 2022.

Note: This document contains side effect information about abaloparatide. Some dosage forms listed on this page may not apply to the brand name Tymlos.

Applies to abaloparatide: subcutaneous solution.

Serious side effects of Tymlos

Along with its needed effects, abaloparatide (the active ingredient contained in Tymlos) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking abaloparatide:

More common

  • Blood in the urine
  • constipation
  • depression
  • loss of appetite
  • loss of weight
  • muscle weakness
  • nausea or vomiting
  • pain in the bone, joint, back, arms, or legs
  • pain in the side, back, or stomach
  • thirst
  • unusual tiredness or weakness

Less common

  • Fast, irregular, pounding, or racing heartbeat or pulse

Incidence not known

Other side effects of Tymlos

Some side effects of abaloparatide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
  • difficulty in moving
  • headache
  • muscle pain or stiffness

Less common

  • Dizziness, faintness, or lightheadedness when getting up from a lying or sitting position
  • feeling of constant movement of self or surroundings
  • sensation of spinning
  • unusual bruising

Incidence not known

  • Diarrhea
  • full or bloated feeling
  • general feeling of discomfort or illness
  • itching, rash
  • lack or loss of strength
  • muscle spasms of the leg and back
  • pressure in the stomach
  • swelling of the stomach area
  • trouble sleeping
  • unusual drowsiness, dullness, or feeling of sluggishness

For Healthcare Professionals

Applies to abaloparatide: subcutaneous solution.


The most common side effects resulting in discontinuation were nausea, dizziness, headache, and palpitations.


Common (1% to 10%): Palpitations, tachycardia (including sinus tachycardia), orthostatic hypotension[Ref]


Postmarketing reports: Pruritus, rash


Common (1% to 10%): Nausea, upper abdominal pain, abdominal distention, diarrhea

Postmarketing reports: Abdominal distention, abdominal pain, constipation, diarrhea, vomiting[Ref]


Postmarketing reports: Hypersensitivity and anaphylactic reaction


Very common (10% or more): Immunogenicity[Ref]


Very common (10% or more): Redness at injection site (58%), edema at injection site (11%), pain at injection site (10%)

Common (1% to 10%): Contusion at injection site

Postmarketing reports: Injection site bruising, hemorrhage[Ref]


Very common (10% or more): Increased serum uric acid (25%)

Common (1% to 10%): Hypercalcemia[Ref]

Nervous system

Very common (10% or more): Dizziness (10%)

Common (1% to 10%): Headache

Postmarketing reports: Lethargy[Ref]


Common (1% to 10%): Fatigue, vertigo

Postmarketing reports: Asthenia, malaise


Postmarketing reports: Insomnia


Very common (10% or more): Hypercalciuria (20%)

Common (1% to 10%): Urolithiasis[Ref]


Postmarketing reports: Dyspnea


Common (1% to 10%): Arthralgia, bone pain

Postmarketing reports: Bone pain, joint pain, back pain, extremity pain, leg and back muscle spasms

Frequently asked questions


1. Product Information. Tymlos (abaloparatide). Radius Health. 2017.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.