Trandolapril Side Effects

Medically reviewed by Drugs.com. Last updated on Jun 30, 2024.

Applies to trandolapril: oral tablet.

Precautions

It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly. Blood and urine tests may be needed to check for unwanted effects.

Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using this medicine, tell your doctor right away.

You should not use this medicine together with sacubitril. Do not use this medicine and sacubitril/valsartan (Entresto®) within 36 hours of each other.

This medicine may cause serious allergic reactions, including anaphylaxis. This can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash, itching, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth while you are using this medicine.

Call your doctor right away if you have severe stomach pain (with or without nausea or vomiting). This could be a symptom of a condition called intestinal angioedema.

Dizziness, lightheadedness, or fainting may also occur, especially when you get up from a lying or sitting position or if you have been taking a diuretic (water pill). Do not drive or do anything else that could be dangerous until you know how this medicine affects you. If you feel dizzy, lie down so you do not faint. Then sit for a few moments before standing to prevent the dizziness from returning.

Check with your doctor right away if you become sick while taking this medicine, especially with severe or continuing nausea, vomiting, or diarrhea. These conditions may cause you to lose too much water or salt and may lead to low blood pressure. You can also lose water by sweating, so drink plenty of water during exercise or in hot weather.

Check with your doctor if you have a fever, chills, or sore throat. These may be symptoms of an infection resulting from low white blood cells. .

Check with your doctor right away if you have pain or tenderness in the upper stomach, dark urine, pale stools, nausea, vomiting, or yellow skin or eyes. These could be symptoms of a serious liver problem.

Hyperkalemia (high potassium in the blood) may occur while you are using this medicine. Check with your doctor right away if you have the following symptoms: abdominal or stomach pain, confusion, difficulty with breathing, irregular heartbeat, nausea or vomiting, nervousness, numbness or tingling in the hands, feet, or lips, shortness of breath, or weakness or heaviness of the legs. Ask your doctor before you use any medicine, salt substitute, or supplement that contains potassium.

Make sure any doctor or dentist who treats you knows that you are using this medicine. You may need to stop using this medicine several days before having surgery.

Check with your doctor right away if you have bloody urine, a decrease in frequency or amount of urine, an increase in blood pressure, increased thirst, loss of appetite, lower back or side pain, nausea, swelling of the face, fingers, or lower legs, troubled breathing, unusual tiredness or weakness, vomiting, or weight gain. These could be symptoms of a serious kidney problem.

This medicine may be less effective in black patients. Black patients also have an increased risk of angioedema (swelling of the hands, arms, face, mouth, or throat).

Do not take other medicines unless they have been discussed with your doctor. This especially includes prescription or nonprescription (over-the-counter [OTC]) medicines for appetite control, asthma, colds, cough, hay fever, or sinus problems, and herbal or vitamin supplements, since they may tend to increase your blood pressure.

Serious side effects of trandolapril

Along with its needed effects, trandolapril may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking trandolapril:

Other side effects of trandolapril

Some side effects of trandolapril may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For healthcare professionals

Applies to trandolapril: oral tablet.

General adverse events

The most frequently reported side effects were dizziness and a dry, nonproductive cough.^[Ref]

Respiratory

• Very common (10% or more): Cough (up to 35%)
• Common (1% to 10%): Bronchitis, upper respiratory tract infections, rhinitis
• Uncommon (0.1% to 1%): Dyspnea, sore throat, hoarseness, epistaxis, throat inflammation
• Very rare (less than 0.01%): Bronchospasm, sinusitis, lung infiltration, allergic alveolitis, eosinophilic pneumonia^[Ref]

Nervous system

• Very common (10% or more): Dizziness (up to 23%)
• Common (1% to 10%): Headache
• Uncommon (0.1% to 1%): Paresthesia, vertigo, taste disturbances, sleep disturbance, insomnia, transient ischemic attacks, drowsiness, cerebral hemorrhage, somnolence
• Rare (less than 0.1%): Muscle convulsions, disturbance of balance^[Ref]

Cardiovascular

• Very common (10% or more): Hypotension (up to 11%)
• Common (1% to 10%): Orthostatic effects, syncope, bradycardia, cardiogenic shock, intermittent claudication, stroke, percutaneous transluminal coronary angioplasty, coronary artery bypass graft surgery
• Uncommon (0.1% to 1%): Myocardial infarction, cerebrovascular accident, palpitations, tachycardia, Raynaud's phenomenon, chest pain, arrhythmias, angina pectoris, cerebral hemorrhage, AV first degree block, edema, flushing
• Frequency not reported: Vasculitis
• Postmarketing reports: Myocardial ischemia, cardiac failure, ventricular tachycardia^[Ref]

Renal

• Common (1% to 10%): Renal dysfunction, elevated BUN, increased creatinine
• Uncommon (0.1% to 1%): Deterioration of renal function, acute renal failure
• Rare (0.01% to 0.1%): Uremia
• Very rare (less than 0.01%): Bacterial interstitial nephritis^[Ref]

Dermatologic

• Common (1% to 10%): Rash
• Uncommon (0.1% to 1%): Pruritus, angioedema, pemphigus, non-specific skin disorder
• Rare (0.01% to 0.1%): Hypersensitivity/angioneurotic edema, urticaria, alopecia, psoriasis
• Very rare (less than 0.01%): Diaphoresis, toxic epidermal necrolysis, Stevens-Johnson syndrome, erythema multiforme, photosensitivity, blushing, onycholysis^[Ref]

Gastrointestinal

• Common (1% to 10%): Diarrhea, vomiting, dyspepsia, gastritis, gastrointestinal pain
• Uncommon (0.1% to 1%): Nausea, abdominal pain, indigestion, anorexia, gastrointestinal disorder, constipation, dry mouth, abdominal distention, abdominal cramps
• Rare (0.01% to 0.1%): Loss of appetite
• Very rare (less than 0.01%): Pancreatitis, intestinal angioedema, stomatitis, glossitis^[Ref]

Metabolic

• Very common (10% or more): Increased serum uric acid (15%)
• Common (1% to 10%): Hyperkalemia, hypocalcemia
• Uncommon (0.1% to 1%): Increased blood urea, gout
• Rare (0.01% to 0.1%): Hyponatremia
• Very rare (less than 0.01%): Hypoglycemia^[Ref]

Hematologic

• Uncommon (0.1% to 1%): Decreased leukocytes, decreased neutrophils
• Rare (0.01% to 0.1%): Decreased hemoglobin, decreased hematocrit
• Very rare (less than 0.01%): Bone marrow depression, anemia, thrombocytopenia, leukopenia, neutropenia, eosinophilia, agranulocytosis, hemolytic anemia, lymphadenopathy, autoimmune disease
• Frequency not reported: Elevated red blood cell sedimentation rate (ESR), leukocytosis
• Postmarketing reports: Pancytopenia, decreased platelets^[Ref]

Musculoskeletal

• Common (1% to 10%): Myalgia
• Uncommon (0.1% to 1%): Muscle cramps, pain in extremities
• Frequency not reported: Arthralgia, arthritis^[Ref]

Genitourinary

• Common (1% to 10%): Urinary infection
• Uncommon (0.1% to 1%): Impotence, decreased libido
• Rare (0.01% to 0.1%): Proteinuria
• Very rare (less than 0.01%): Oliguria, anuria^[Ref]

Hepatic

• Uncommon (0.1% to 1%): Increased liver enzymes
• Rare (0.01% to 0.1%): Increased serum bilirubin
• Very rare (less than 0.01%): Hepatocellular or cholestatic hepatitis, jaundice^[Ref]

Hypersensitivity

• Postmarketing reports: Allergic hypersensitivity reactions (including pruritus and rash)^[Ref]

Other

• Common (1% to 10%): Fatigue, influenza-like syndrome, asthenia, malaise
• Uncommon (0.1% to 1%): Abnormal feeling
• Rare (less than 0.1%): Tinnitus
• Postmarketing reports: Fever^[Ref]

Psychiatric

• Uncommon (0.1% to 1%): Mood alterations, anxiety, depression
• Rare (less than 0.1%): Mental confusion, nervousness
• Postmarketing reports: Hallucinations^[Ref]

Endocrine

• Rare (less than 0.1%): Gynecomastia^[Ref]

Ocular

• Rare (less than 0.1%): Blurred vision^[Ref]

Immunologic

• Frequency not reported: Positive antinuclear antibodies (ANA)^[Ref]

See also:

Further information

Trandolapril side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

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