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Trandolapril Side Effects

In Summary

Commonly reported side effects of trandolapril include: cough, dizziness, and hypotension. Other side effects include: cardiogenic shock, syncope, hyperkalemia, increased serum creatinine, and increased blood urea nitrogen. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to trandolapril: oral capsule, oral tablet

As well as its needed effects, trandolapril may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking trandolapril, check with your doctor immediately:

More common:
  • Abdominal or stomach pain
  • blurred vision
  • confusion
  • difficulty with breathing
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fainting
  • irregular heartbeat
  • nausea or vomiting
  • nervousness
  • numbness or tingling in the hands, feet, or lips
  • sweating
  • unusual tiredness or weakness
  • weakness or heaviness of the legs
Less common:
  • Abdominal or stomach cramps
  • chest pain or discomfort
  • cool, sweaty skin
  • difficulty with speaking
  • double vision
  • inability to move the arms, legs, or facial muscles
  • muscle cramps in the hands, arms, feet, legs, or face
  • numbness and tingling around the mouth
  • seizures
  • slow heartbeat
  • tremor

Minor Side Effects

Some trandolapril side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common:
  • Acid or sour stomach
  • belching
  • cough
  • heartburn
  • indigestion
  • stomach discomfort or upset
Less common:
  • Burning feeling in the chest or stomach
  • difficulty with moving
  • joint pain
  • muscle aches, pain, or stiffness
  • swollen joints
  • tenderness in the stomach area

For Healthcare Professionals

Applies to trandolapril: oral tablet


The most frequently reported side effects were dizziness and a dry, nonproductive cough.[Ref]


Very common (10% or more): Cough (up to 35%)
Common (1% to 10%): Bronchitis, upper respiratory tract infections, rhinitis
Uncommon (0.1% to 1%): Dyspnea, sore throat, hoarseness, epistaxis, throat inflammation
Very rare (less than 0.01%): Bronchospasm, sinusitis, lung infiltration, allergic alveolitis, eosinophilic pneumonia[Ref]

Nervous system

Very common (10% or more): Dizziness (up to 23%)
Common (1% to 10%): Headache
Uncommon (0.1% to 1%): Paresthesia, vertigo, taste disturbances, sleep disturbance, insomnia, transient ischemic attacks, drowsiness, cerebral hemorrhage, somnolence
Rare (less than 0.1%): Muscle convulsions, disturbance of balance[Ref]


Very common (10% or more): Hypotension (up to 11%)
Common (1% to 10%): Orthostatic effects, syncope, bradycardia, cardiogenic shock, intermittent claudication, stroke, percutaneous transluminal coronary angioplasty, coronary artery bypass graft surgery
Uncommon (0.1% to 1%): Myocardial infarction, cerebrovascular accident, palpitations, tachycardia, Raynaud's phenomenon, chest pain, arrhythmias, angina pectoris, cerebral hemorrhage, AV first degree block, edema, flushing
Frequency not reported: Vasculitis
Postmarketing reports: Myocardial ischemia, cardiac failure, ventricular tachycardia[Ref]


Common (1% to 10%): Renal dysfunction, elevated BUN, increased creatinine
Uncommon (0.1% to 1%): Deterioration of renal function, acute renal failure
Rare (0.01% to 0.1%): Uremia
Very rare (less than 0.01%): Bacterial interstitial nephritis[Ref]


Common (1% to 10%): Rash
Uncommon (0.1% to 1%): Pruritus, angioedema, pemphigus, non-specific skin disorder
Rare (0.01% to 0.1%): Hypersensitivity/angioneurotic edema, urticaria, alopecia, psoriasis
Very rare (less than 0.01%): Diaphoresis, toxic epidermal necrolysis, Stevens-Johnson syndrome, erythema multiforme, photosensitivity, blushing, onycholysis[Ref]


Common (1% to 10%): Diarrhea, vomiting, dyspepsia, gastritis, gastrointestinal pain
Uncommon (0.1% to 1%): Nausea, abdominal pain, indigestion, anorexia, gastrointestinal disorder, constipation, dry mouth, abdominal distention, abdominal cramps
Rare (0.01% to 0.1%): Loss of appetite
Very rare (less than 0.01%): Pancreatitis, intestinal angioedema, stomatitis, glossitis[Ref]


Very common (10% or more): Increased serum uric acid (15%)
Common (1% to 10%): Hyperkalemia, hypocalcemia
Uncommon (0.1% to 1%): Increased blood urea, gout
Rare (0.01% to 0.1%): Hyponatremia
Very rare (less than 0.01%): Hypoglycemia[Ref]


Uncommon (0.1% to 1%): Decreased leukocytes, decreased neutrophils
Rare (0.01% to 0.1%): Decreased hemoglobin, decreased hematocrit
Very rare (less than 0.01%): Bone marrow depression, anemia, thrombocytopenia, leukopenia, neutropenia, eosinophilia, agranulocytosis, hemolytic anemia, lymphadenopathy, autoimmune disease
Frequency not reported: Elevated red blood cell sedimentation rate (ESR), leukocytosis
Postmarketing reports: Pancytopenia, decreased platelets[Ref]


Common (1% to 10%): Myalgia
Uncommon (0.1% to 1%): Muscle cramps, pain in extremities
Frequency not reported: Arthralgia, arthritis[Ref]


Common (1% to 10%): Urinary infection
Uncommon (0.1% to 1%): Impotence, decreased libido
Rare (0.01% to 0.1%): Proteinuria
Very rare (less than 0.01%): Oliguria, anuria[Ref]


Uncommon (0.1% to 1%): Increased liver enzymes
Rare (0.01% to 0.1%): Increased serum bilirubin
Very rare (less than 0.01%): Hepatocellular or cholestatic hepatitis, jaundice[Ref]


Postmarketing reports: Allergic hypersensitivity reactions (including pruritus and rash)[Ref]


Common (1% to 10%): Fatigue, influenza-like syndrome, asthenia, malaise
Uncommon (0.1% to 1%): Abnormal feeling
Rare (less than 0.1%): Tinnitus
Postmarketing reports: Fever[Ref]


Uncommon (0.1% to 1%): Mood alterations, anxiety, depression
Rare (less than 0.1%): Mental confusion, nervousness
Postmarketing reports: Hallucinations[Ref]


Rare (less than 0.1%): Gynecomastia[Ref]


Rare (less than 0.1%): Blurred vision[Ref]


Frequency not reported: Positive antinuclear antibodies (ANA)[Ref]


1. "Product Information. Mavik (trandolapril)." Knoll Pharmaceutical Company, Whippany, NJ.

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

3. Cerner Multum, Inc. "Australian Product Information." O 0

It is possible that some side effects of trandolapril may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.