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Trandolapril Side Effects

In Summary

Commonly reported side effects of trandolapril include: cough, dizziness, and hypotension. Other side effects include: cardiogenic shock, syncope, hyperkalemia, increased serum creatinine, and increased blood urea nitrogen. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to trandolapril: oral capsule, oral tablet

Along with its needed effects, trandolapril may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking trandolapril:

More common
  • Blurred vision
  • confusion
  • difficulty with breathing
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fainting
  • irregular heartbeat
  • nausea
  • nervousness
  • numbness or tingling in the hands, feet, or lips
  • stomach pain
  • sweating
  • unusual tiredness or weakness
  • vomiting
  • weakness or heaviness of the legs
Less common
  • Chest pain or discomfort
  • cool, sweaty skin
  • difficulty with speaking
  • double vision
  • inability to move the arms, legs, or facial muscles
  • muscle cramps in the hands, arms, feet, legs, or face
  • numbness and tingling around the mouth
  • seizures
  • slow heartbeat
  • stomach cramps
  • tremor

Some side effects of trandolapril may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common Less common
  • Burning feeling in the chest or stomach
  • difficulty with moving
  • joint pain
  • muscle aches, pain, or stiffness
  • swollen joints
  • tenderness in the stomach area

For Healthcare Professionals

Applies to trandolapril: oral tablet


The most frequently reported side effects were dizziness and a dry, nonproductive cough.[Ref]


Very common (10% or more): Cough (up to 35%)
Common (1% to 10%): Bronchitis, upper respiratory tract infections, rhinitis
Uncommon (0.1% to 1%): Dyspnea, sore throat, hoarseness, epistaxis, throat inflammation
Very rare (less than 0.01%): Bronchospasm, sinusitis, lung infiltration, allergic alveolitis, eosinophilic pneumonia[Ref]

Nervous system

Very common (10% or more): Dizziness (up to 23%)
Common (1% to 10%): Headache
Uncommon (0.1% to 1%): Paresthesia, vertigo, taste disturbances, sleep disturbance, insomnia, transient ischemic attacks, drowsiness, cerebral hemorrhage, somnolence
Rare (less than 0.1%): Muscle convulsions, disturbance of balance[Ref]


Very common (10% or more): Hypotension (up to 11%)
Common (1% to 10%): Orthostatic effects, syncope, bradycardia, cardiogenic shock, intermittent claudication, stroke, percutaneous transluminal coronary angioplasty, coronary artery bypass graft surgery
Uncommon (0.1% to 1%): Myocardial infarction, cerebrovascular accident, palpitations, tachycardia, Raynaud's phenomenon, chest pain, arrhythmias, angina pectoris, cerebral hemorrhage, AV first degree block, edema, flushing
Frequency not reported: Vasculitis
Postmarketing reports: Myocardial ischemia, cardiac failure, ventricular tachycardia[Ref]


Common (1% to 10%): Renal dysfunction, elevated BUN, increased creatinine
Uncommon (0.1% to 1%): Deterioration of renal function, acute renal failure
Rare (0.01% to 0.1%): Uremia
Very rare (less than 0.01%): Bacterial interstitial nephritis[Ref]


Common (1% to 10%): Rash
Uncommon (0.1% to 1%): Pruritus, angioedema, pemphigus, non-specific skin disorder
Rare (0.01% to 0.1%): Hypersensitivity/angioneurotic edema, urticaria, alopecia, psoriasis
Very rare (less than 0.01%): Diaphoresis, toxic epidermal necrolysis, Stevens-Johnson syndrome, erythema multiforme, photosensitivity, blushing, onycholysis[Ref]


Common (1% to 10%): Diarrhea, vomiting, dyspepsia, gastritis, gastrointestinal pain
Uncommon (0.1% to 1%): Nausea, abdominal pain, indigestion, anorexia, gastrointestinal disorder, constipation, dry mouth, abdominal distention, abdominal cramps
Rare (0.01% to 0.1%): Loss of appetite
Very rare (less than 0.01%): Pancreatitis, intestinal angioedema, stomatitis, glossitis[Ref]


Very common (10% or more): Increased serum uric acid (15%)
Common (1% to 10%): Hyperkalemia, hypocalcemia
Uncommon (0.1% to 1%): Increased blood urea, gout
Rare (0.01% to 0.1%): Hyponatremia
Very rare (less than 0.01%): Hypoglycemia[Ref]


Uncommon (0.1% to 1%): Decreased leukocytes, decreased neutrophils
Rare (0.01% to 0.1%): Decreased hemoglobin, decreased hematocrit
Very rare (less than 0.01%): Bone marrow depression, anemia, thrombocytopenia, leukopenia, neutropenia, eosinophilia, agranulocytosis, hemolytic anemia, lymphadenopathy, autoimmune disease
Frequency not reported: Elevated red blood cell sedimentation rate (ESR), leukocytosis
Postmarketing reports: Pancytopenia, decreased platelets[Ref]


Common (1% to 10%): Myalgia
Uncommon (0.1% to 1%): Muscle cramps, pain in extremities
Frequency not reported: Arthralgia, arthritis[Ref]


Common (1% to 10%): Urinary infection
Uncommon (0.1% to 1%): Impotence, decreased libido
Rare (0.01% to 0.1%): Proteinuria
Very rare (less than 0.01%): Oliguria, anuria[Ref]


Uncommon (0.1% to 1%): Increased liver enzymes
Rare (0.01% to 0.1%): Increased serum bilirubin
Very rare (less than 0.01%): Hepatocellular or cholestatic hepatitis, jaundice[Ref]


Postmarketing reports: Allergic hypersensitivity reactions (including pruritus and rash)[Ref]


Common (1% to 10%): Fatigue, influenza-like syndrome, asthenia, malaise
Uncommon (0.1% to 1%): Abnormal feeling
Rare (less than 0.1%): Tinnitus
Postmarketing reports: Fever[Ref]


Uncommon (0.1% to 1%): Mood alterations, anxiety, depression
Rare (less than 0.1%): Mental confusion, nervousness
Postmarketing reports: Hallucinations[Ref]


Rare (less than 0.1%): Gynecomastia[Ref]


Rare (less than 0.1%): Blurred vision[Ref]


Frequency not reported: Positive antinuclear antibodies (ANA)[Ref]


1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. Cerner Multum, Inc. "Australian Product Information." O 0

3. "Product Information. Mavik (trandolapril)." Knoll Pharmaceutical Company, Whippany, NJ.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.