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Trandolapril Side Effects

Medically reviewed by Last updated on Aug 31, 2023.


Commonly reported side effects of trandolapril include: cough, dizziness, and hypotension. Other side effects include: cardiogenic shock, syncope, hyperkalemia, increased serum creatinine, and increased blood urea nitrogen. Continue reading for a comprehensive list of adverse effects.

Applies to trandolapril: oral tablet.


Oral route (Tablet)

Discontinue trandolapril as soon as possible if the patient becomes pregnant, as drugs that target the renin-angiotensin system can cause injury and death to the developing fetus.

Serious side effects of Trandolapril

Along with its needed effects, trandolapril may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking trandolapril:

More common

  • Blurred vision
  • confusion
  • difficulty with breathing
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fainting
  • irregular heartbeat
  • nausea
  • nervousness
  • numbness or tingling in the hands, feet, or lips
  • stomach pain
  • sweating
  • unusual tiredness or weakness
  • vomiting
  • weakness or heaviness of the legs

Less common

  • Chest pain or discomfort
  • cool, sweaty skin
  • difficulty with speaking
  • double vision
  • inability to move the arms, legs, or facial muscles
  • muscle cramps in the hands, arms, feet, legs, or face
  • numbness and tingling around the mouth
  • seizures
  • slow heartbeat
  • stomach cramps
  • tremor

Other side effects of Trandolapril

Some side effects of trandolapril may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Belching
  • cough
  • heartburn
  • indigestion
  • stomach discomfort or upset

Less common

  • Burning feeling in the chest or stomach
  • difficulty with moving
  • joint pain
  • muscle aches, pain, or stiffness
  • swollen joints
  • tenderness in the stomach area

For Healthcare Professionals

Applies to trandolapril: oral tablet.


The most frequently reported side effects were dizziness and a dry, nonproductive cough.[Ref]


Very common (10% or more): Cough (up to 35%)

Common (1% to 10%): Bronchitis, upper respiratory tract infections, rhinitis

Uncommon (0.1% to 1%): Dyspnea, sore throat, hoarseness, epistaxis, throat inflammation

Very rare (less than 0.01%): Bronchospasm, sinusitis, lung infiltration, allergic alveolitis, eosinophilic pneumonia[Ref]

Nervous system

Very common (10% or more): Dizziness (up to 23%)

Common (1% to 10%): Headache

Uncommon (0.1% to 1%): Paresthesia, vertigo, taste disturbances, sleep disturbance, insomnia, transient ischemic attacks, drowsiness, cerebral hemorrhage, somnolence

Rare (less than 0.1%): Muscle convulsions, disturbance of balance[Ref]


Very common (10% or more): Hypotension (up to 11%)

Common (1% to 10%): Orthostatic effects, syncope, bradycardia, cardiogenic shock, intermittent claudication, stroke, percutaneous transluminal coronary angioplasty, coronary artery bypass graft surgery

Uncommon (0.1% to 1%): Myocardial infarction, cerebrovascular accident, palpitations, tachycardia, Raynaud's phenomenon, chest pain, arrhythmias, angina pectoris, cerebral hemorrhage, AV first degree block, edema, flushing

Frequency not reported: Vasculitis

Postmarketing reports: Myocardial ischemia, cardiac failure, ventricular tachycardia[Ref]


Common (1% to 10%): Renal dysfunction, elevated BUN, increased creatinine

Uncommon (0.1% to 1%): Deterioration of renal function, acute renal failure

Rare (0.01% to 0.1%): Uremia

Very rare (less than 0.01%): Bacterial interstitial nephritis[Ref]


Common (1% to 10%): Rash

Uncommon (0.1% to 1%): Pruritus, angioedema, pemphigus, non-specific skin disorder

Rare (0.01% to 0.1%): Hypersensitivity/angioneurotic edema, urticaria, alopecia, psoriasis

Very rare (less than 0.01%): Diaphoresis, toxic epidermal necrolysis, Stevens-Johnson syndrome, erythema multiforme, photosensitivity, blushing, onycholysis[Ref]


Common (1% to 10%): Diarrhea, vomiting, dyspepsia, gastritis, gastrointestinal pain

Uncommon (0.1% to 1%): Nausea, abdominal pain, indigestion, anorexia, gastrointestinal disorder, constipation, dry mouth, abdominal distention, abdominal cramps

Rare (0.01% to 0.1%): Loss of appetite

Very rare (less than 0.01%): Pancreatitis, intestinal angioedema, stomatitis, glossitis[Ref]


Very common (10% or more): Increased serum uric acid (15%)

Common (1% to 10%): Hyperkalemia, hypocalcemia

Uncommon (0.1% to 1%): Increased blood urea, gout

Rare (0.01% to 0.1%): Hyponatremia

Very rare (less than 0.01%): Hypoglycemia[Ref]


Uncommon (0.1% to 1%): Decreased leukocytes, decreased neutrophils

Rare (0.01% to 0.1%): Decreased hemoglobin, decreased hematocrit

Very rare (less than 0.01%): Bone marrow depression, anemia, thrombocytopenia, leukopenia, neutropenia, eosinophilia, agranulocytosis, hemolytic anemia, lymphadenopathy, autoimmune disease

Frequency not reported: Elevated red blood cell sedimentation rate (ESR), leukocytosis

Postmarketing reports: Pancytopenia, decreased platelets[Ref]


Common (1% to 10%): Myalgia

Uncommon (0.1% to 1%): Muscle cramps, pain in extremities

Frequency not reported: Arthralgia, arthritis[Ref]


Common (1% to 10%): Urinary infection

Uncommon (0.1% to 1%): Impotence, decreased libido

Rare (0.01% to 0.1%): Proteinuria

Very rare (less than 0.01%): Oliguria, anuria[Ref]


Uncommon (0.1% to 1%): Increased liver enzymes

Rare (0.01% to 0.1%): Increased serum bilirubin

Very rare (less than 0.01%): Hepatocellular or cholestatic hepatitis, jaundice[Ref]


Postmarketing reports: Allergic hypersensitivity reactions (including pruritus and rash)[Ref]


Common (1% to 10%): Fatigue, influenza-like syndrome, asthenia, malaise

Uncommon (0.1% to 1%): Abnormal feeling

Rare (less than 0.1%): Tinnitus

Postmarketing reports: Fever[Ref]


Uncommon (0.1% to 1%): Mood alterations, anxiety, depression

Rare (less than 0.1%): Mental confusion, nervousness

Postmarketing reports: Hallucinations[Ref]


Rare (less than 0.1%): Gynecomastia[Ref]


Rare (less than 0.1%): Blurred vision[Ref]


Frequency not reported: Positive antinuclear antibodies (ANA)[Ref]


1. Product Information. Mavik (trandolapril). Knoll Pharmaceutical Company. 2001.

2. Cerner Multum, Inc. UK Summary of Product Characteristics.

3. Cerner Multum, Inc. Australian Product Information.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.