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Tenoretic 100 Side Effects

Generic name: atenolol / chlorthalidone

Medically reviewed by Last updated on May 14, 2023.

Note: This document contains side effect information about atenolol / chlorthalidone. Some dosage forms listed on this page may not apply to the brand name Tenoretic 100.

Applies to atenolol / chlorthalidone: oral tablet.

Serious side effects of Tenoretic 100

Along with its needed effects, atenolol/chlorthalidone may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking atenolol / chlorthalidone:

More common

Less common

Incidence not determined

Get emergency help immediately if any of the following symptoms of overdose occur while taking atenolol / chlorthalidone:

Symptoms of overdose

Other side effects of Tenoretic 100

Some side effects of atenolol / chlorthalidone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common

Incidence not determined

For Healthcare Professionals

Applies to atenolol / chlorthalidone: oral tablet.


The most common adverse reactions were bradycardia, cold extremities, gastrointestinal disturbances, fatigue, hyperuricemia, hyponatremia, hypokalemia, and impaired glucose tolerance.[Ref]


Common (1% to 10%): Hyperuricemia, hyponatremia, hypokalemia, impaired glucose tolerance

Chlorthalidone (chlortalidone):

Frequency not reported: Anorexia, hyperglycemia, hyperuricemia[Ref]


Common (1% to 10%): Bradycardia, cold extremities

Rare (less than 0.1%): Heart failure deterioration, heart block precipitation, postural hypotension, intermittent claudication increased, Raynaud's phenomenon


Very common (10% or more): Cold extremities (up to 12%)

Common (1% to 10%): Bradycardia, postural hypotension

Postmarketing reports: Sick sinus syndrome, Raynaud's phenomenon

Chlorthalidone (chlortalidone):

Frequency not reported: Orthostatic hypotension, necrotizing angiitis[Ref]


Common (1% to 10%): Gastrointestinal disturbances

Rare (less than 0.1%): Dry mouth

Frequency not reported: Constipation


Common (1% to 10%): Diarrhea, nausea

Postmarketing reports: Dry mouth

Chlorthalidone (chlortalidone):

Frequency not reported: Gastric irritation, vomiting, cramping, constipation, pancreatitis[Ref]


Common (1% to 10%): Fatigue


Very common (10% or more): Tiredness (up to 26%)

Common (1% to 10%): Fatigue, lethargy

Chlorthalidone (chlortalidone):

Frequency not reported: Weakness[Ref]


Uncommon (0.1% to 1%): Sleep disturbances

Rare (less than 0.1%): Mood changes, nightmares, confusion, psychoses, hallucinations


Very common (10% or more): Depression (up to 12%)

Common (1% to 10%): Dreaming

Postmarketing reports: Hallucinations, psychoses

Chlorthalidone (chlortalidone):

Frequency not reported: Restlessness[Ref]


Uncommon (0.1% to 1%): Transaminase levels increased

Rare (less than 0.1%): Hepatic toxicity


Postmarketing reports: Liver enzymes elevated, bilirubin elevated

Chlorthalidone (chlortalidone):

Frequency not reported: Intrahepatic cholestatic jaundice[Ref]


Rare (less than 0.1%): Purpura, alopecia, psoriasiform skin reaction, psoriasis exacerbation, skin rashes

Frequency not reported: Angioedema, urticaria


Postmarketing reports: Psoriasiform rash, psoriasis exacerbation, purpura, reversible alopecia

Chlorthalidone (chlortalidone):

Frequency not reported: Purpura, photosensitivity, rash, urticaria, cutaneous vasculitis, toxic epidermal necrolysis[Ref]

Nervous system

Rare (less than 0.1%): Dizziness, headache, paresthesia


Very common (10% or more): Dizziness (up to 13%)

Common (1% to 10%): Vertigo, lightheadedness, drowsiness

Postmarketing reports: Headache

Chlorthalidone (chlortalidone):

Frequency not reported: Vertigo, paresthesia[Ref]


Rare (less than 0.1%): Thrombocytopenia, leukopenia


Postmarketing reports: Thrombocytopenia

Chlorthalidone (chlortalidone):

Frequency not reported: Leukopenia, agranulocytosis, thrombocytopenia, aplastic anemia[Ref]


Rare (less than 0.1%): Dry eyes, visual disturbances


Postmarketing reports: Visual disturbance

Chlorthalidone (chlortalidone):

Frequency not reported: Xanthopsia[Ref]


Rare (less than 0.1%): Bronchospasm


Common (1% to 10%): Wheeziness, dyspnea[Ref]


Rare (less than 0.1%): Impotence


Postmarketing reports: Impotence, Peyronie's disease

Chlorthalidone (chlortalidone):

Frequency not reported: Glycosuria[Ref]


Very rare (less than 0.01%): Antinuclear antibodies increased

Frequency not reported: Hypersensitivity reactions


Postmarketing reports: Development of antinuclear antibodies[Ref]


Frequency not reported: Lupus-like syndrome


Common (1% to 10%): Leg pain

Postmarketing reports: Lupus syndrome

Chlorthalidone (chlortalidone):

Frequency not reported: Muscle spasm[Ref]


1. Product Information. Tenoretic (atenolol-chlorthalidone). Astra-Zeneca Pharmaceuticals. 2001;PROD.

2. Cerner Multum, Inc. UK Summary of Product Characteristics.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.