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Atenolol / chlorthalidone Pregnancy and Breastfeeding Warnings

Brand names: Tenoretic, Tenoretic 100, Tenoretic 50

Medically reviewed by Drugs.com. Last updated on Sep 30, 2024.

Atenolol / chlorthalidone Pregnancy Warnings

This drug should not be used during pregnancy unless the benefit outweighs the risk to the fetus; per some authorities, use is contraindicated for hypertension during pregnancy.

US FDA pregnancy category: Not assigned.

Risk summary: Adverse fetal outcomes, including fetal or neonatal jaundice, thrombocytopenia, hypoglycemia, and electrolyte abnormalities have been reported following maternal use of thiazide diuretics.

Comments:
-If this drug is used during pregnancy, or if the patient becomes pregnant while taking this drug, the patient should be apprised of the potential harm to the fetus.
-This drug enters fetal circulation and can cause placental hypoperfusion.
-Neonates exposed to atenolol during parturition may have a higher risk of developing bradycardia or hypoglycemia.

Animal studies have revealed embryonic resorptions. Atenolol has been shown to produce a dose-related increase in embryofetal resorptions in rats. In humans, atenolol administration starting in the second trimester has been associated with the birth of infants that are small for gestational age. Controlled data in human pregnancy exists only for atenolol in the second and third trimesters of pregnancy.

US FDA pregnancy category Not Assigned: The US FDA has amended the pregnancy labeling rule for prescription drug products to require labeling that includes a summary of risk, a discussion of the data supporting that summary, and relevant information to help health care providers make prescribing decisions and counsel women about the use of drugs during pregnancy. Pregnancy categories A, B, C, D, and X are being phased out.

See references

Atenolol / chlorthalidone Breastfeeding Warnings

Use should be avoided.

Excreted into human milk: Yes (atenolol, chlorthalidone [chlortalidone])

See references

Does Atenolol/chlorthalidone interact with my other drugs?

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See also

References for pregnancy information

  1. (2001) "Product Information. Tenoretic (atenolol-chlorthalidone)." Astra-Zeneca Pharmaceuticals
  2. Cerner Multum, Inc. "UK Summary of Product Characteristics."
  3. (2018) "Product Information. Co-tenidone (co-tenidone)." Sigma Pharmaceuticals Plc

References for breastfeeding information

  1. (2001) "Product Information. Tenoretic (atenolol-chlorthalidone)." Astra-Zeneca Pharmaceuticals
  2. Cerner Multum, Inc. "UK Summary of Product Characteristics."
  3. United States National Library of Medicine (2013) Toxnet. Toxicology Data Network. http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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