Medically reviewed on November 24, 2017.
What is atenolol and chlorthalidone?
Atenolol is a beta-blocker. Beta-blockers affect the heart and circulation (blood flow through arteries and veins).
Chlorthalidone is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention.
Atenolol and chlorthalidone may also be used for purposes not listed in this medication guide.
Do not use if you are pregnant. It could harm the unborn baby.
Before taking this medicine
You should not use this medicine if you are allergic to atenolol or chlorthalidone, or if you have:
a serious heart problem such as heart block, or slow heart rate;
if you are unable to urinate; or
To make sure atenolol and chlorthalidone is safe for you, tell your doctor if you have:
a history of heart disease;
circulation problems, coronary artery disease (hardened arteries);
angina (chest pain);
asthma, bronchitis, or other lung disorder;
an electrolyte imbalance (such as low levels of potassium in your blood);
a thyroid disorder;
adrenal gland tumor (also called pheochromocytoma).
FDA pregnancy category D. Do not use atenolol and chlorthalidone if you are pregnant. It could harm the unborn baby. Use effective birth control, and tell your doctor if you become pregnant during treatment.
Atenolol and chlorthalidone can pass into breast milk and may harm a nursing baby. You should not breast-feed while using this medicine.
How should I take atenolol and chlorthalidone?
Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended.
While using atenolol and chlorthalidone, your blood pressure will need to be checked often and you may need frequent blood tests.
Vomiting, diarrhea, or heavy sweating can cause you to become dehydrated. This can lead to very low blood pressure, electrolyte disorders, or kidney failure while you are taking atenolol and chlorthalidone. Drink plenty of water each day while you are taking this medicine.
Keep using this medicine as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medicine for the rest of your life.
If you need surgery, tell the surgeon ahead of time that you are using atenolol and chlorthalidone. You may need to stop using the medicine for a short time.
You should not stop using atenolol and chlorthalidone suddenly. Stopping suddenly may make your condition worse. If you do stop taking this medicine, limit your physical activity to prevent heart problems.
Store at room temperature away from moisture, heat, and light.
What happens if I miss a dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while taking atenolol and chlorthalidone?
Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.
Atenolol and chlorthalidone side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
cold feeling in your hands and feet;
jaundice (yellowing of the skin or eyes);
low levels of sodium in the body--headache, confusion, slurred speech, severe weakness, vomiting, loss of coordination, feeling unsteady;
low potassium--confusion, uneven heart rate, extreme thirst, increased urination, leg discomfort, muscle weakness or limp feeling; or
signs of electrolyte imbalance--dry mouth, increased thirst, weakness, restless feeling, confusion, nausea, vomiting, increased urination, muscle pain or weakness, fast heart rate, feeling light-headed, fainting, or seizure (convulsions).
Common side effects may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
Atenolol and chlorthalidone dosing information
Usual Adult Dose for Hypertension:
Initial dose: Atenolol 50 mg-Chlorthalidone 25 mg orally once a day
Maintenance dose: Atenolol 50 to 100 mg-Chlorthalidone 25 mg orally once a day
Use: Treatment of hypertension if the fixed dose combination represents an appropriate dose for the individual patient.
What other drugs will affect atenolol and chlorthalidone?
Tell your doctor about all medicines you use, and those you start or stop using during your treatment with atenolol and chlorthalidone, especially:
any other diuretics or blood pressure medicines;
This list is not complete. Other drugs may interact with atenolol and chlorthalidone, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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- Drug class: beta blockers with thiazides