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Rocklatan Side Effects

Generic name: latanoprost / netarsudil ophthalmic

Medically reviewed by Last updated on May 10, 2023.

Note: This document contains side effect information about latanoprost / netarsudil ophthalmic. Some dosage forms listed on this page may not apply to the brand name Rocklatan.

Applies to latanoprost/netarsudil ophthalmic: ophthalmic solution.

Serious side effects of Rocklatan

Along with its needed effects, latanoprost/netarsudil ophthalmic may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking latanoprost / netarsudil ophthalmic:

More common

  • Bloody eye
  • blurred vision or any other change in vision
  • eye redness, irritation, or pain
  • redness of the eye


  • Body aches or pain
  • burning and stinging of the eye
  • change in color vision
  • chills
  • cough
  • diarrhea
  • difficulty in breathing
  • difficulty seeing at night
  • difficulty swallowing
  • dizziness
  • dry eye
  • ear congestion
  • excessive tearing
  • eyelid discomfort, swelling, or redness
  • fast heartbeat
  • fever
  • general feeling of discomfort or illness
  • headache
  • hives, itching, skin rash
  • increased sensitivity of the eyes to sunlight
  • joint pain
  • loss of appetite
  • loss of voice
  • nausea
  • painful irritation of the clear front part of the eye
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • runny or stuffy nose
  • shivering
  • sneezing
  • sore throat
  • sweating
  • tightness in the chest
  • trouble sleeping
  • unusual tiredness or weakness
  • vomiting

Other side effects of Rocklatan

Some side effects of latanoprost / netarsudil ophthalmic may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Eye itching
  • pain and discomfort at the instillation site

Less common

  • Increase in brown color in the colored part of the eye
  • redness of the white part of the eyes or the inside of the eyelids


  • Back pain
  • crusting in the corner of the eye
  • difficulty in moving
  • discoloration of the white part of the eye
  • feeling of having something in the eye
  • joint pain or swelling
  • muscle pain, cramps, or stiffness

For Healthcare Professionals

Applies to latanoprost / netarsudil ophthalmic: ophthalmic solution.


The most commonly reported side effects included conjunctival hyperemia, instillation site pain, and corneal verticillata.[Ref]


Very common (10% or more): Conjunctival hyperemia (up to 59%), corneal verticillata (up to 15%), conjunctival hemorrhage (up to 11%)

Common (1% to 10%): Blurred vision, eye pruritus, increased lacrimation, visual acuity reduced


-Frequency not reported: Dry eye, erythema of the eyelid, excessive tearing, eye pain, eyelid discomfort, eyelid edema, eyelid margin crusting, foreign body sensation, increased pigmentation of the iris, photophobia, punctate keratitis


-Frequency not reported: Corneal staining, erythema of eyelid, increased lacrimation[Ref]



-Frequency not reported: Itching, rash[Ref]

Nervous system


-Frequency not reported: Burning[Ref]



-Frequency not reported: Allergic reactions[Ref]



-Frequency not reported: Influenza[Ref]


Very common (10% or more): Instillation site pain (up to 20%)

Common (1% to 10%): Instillation site discomfort


-Frequency not reported: Instillation site erythema[Ref]



-Frequency not reported: Arthralgia, back pain, myalgia[Ref]



-Frequency not reported: Stinging[Ref]



-Frequency not reported: Nasopharyngitis, upper respiratory tract infection[Ref]


1. Product Information. Rocklatan (latanoprost-netarsudil ophthalmic). Aerie Pharmaceuticals. 2019.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.