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Quinapril Side Effects

For the Consumer

Applies to quinapril: oral tablet

Along with its needed effects, quinapril may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking quinapril:

Less common
  • Blurred vision
  • chest pain
  • confusion
  • diarrhea
  • difficult or labored breathing
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • nausea
  • stomach pain
  • sweating
  • tightness in the chest
  • unusual tiredness or weakness
  • vomiting
Rare
  • Bleeding gums
  • cold, clammy skin
  • enlarged pupils
  • fast or slow heartbeat
  • increased sensitivity of the skin or eyes to sunlight
  • stiff or sore neck

Some side effects of quinapril may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Headache
Less common
  • Back pain
  • coughing
  • difficulty with moving
  • joint pain
  • muscle aching or cramping
  • muscle pains or stiffness
  • rash
  • swollen joints

For Healthcare Professionals

Applies to quinapril: oral tablet

General

The most commonly reported side effects were dizziness, increased serum creatinine, increased blood urea nitrogen, cough, dyspnea, nausea, vomiting, and diarrhea.[Ref]

Cardiovascular

Uncommon (0.1% to 1%): Chest pain, hypotension, palpitations, vasodilation, tachycardia, heart failure, myocardial infarction, hypertensive crisis, angina pectoris, orthostatic hypotension, cardiac rhythm disturbances, cardiogenic shock[Ref]

Renal

Common (1% to 10%): Increased serum creatinine, increased blood urea nitrogen
Uncommon (0.1% to 1%): Urinary tract infection, acute renal failure/dysfunction, worsening renal failure, proteinuria
Frequency not reported: Increases in blood urea nitrogen and serum creatinine[Ref]

Metabolic

Uncommon (0.1% to 1%): Hyperkalemia, hyponatremia[Ref]

Hematologic

Uncommon (0.1% to 1%): Hemolytic anemia, agranulocytosis, thrombocytopenia
Frequency not reported: Neutropenia, decreased hemoglobin, decreased hematocrit[Ref]

Hypersensitivity

Uncommon (0.1% to 1%): Angioedema of the head, neck, face, extremities, lips, tongue, glottis and/or larynx, intestines; anaphylactoid reactions[Ref]

Hepatic

Uncommon (0.1% to 1%): Abnormal liver function tests, hepatitis
Rare (less than 0.1%): Hepatic failure (characterized by cholestatic jaundice with progression to fulminant hepatic necrosis and sometimes death)
Frequency not reported: Cholestatic icterus[Ref]

Nervous system

Common (1% to 10%): Dizziness
Uncommon (0.1% to 1%): Headache, cerebrovascular accident/cerebral hemorrhage, somnolence, vertigo, syncope, nervousness, paresthesia, transient ischemic attacks, tinnitus
Rare (less than 0.1%): Balance disorder[Ref]

Gastrointestinal

Common (1% to 10%): Nausea, vomiting, diarrhea, dyspepsia, abdominal pain
Uncommon (0.1% to 1%): Flatulence, dry mouth or throat, constipation, gastrointestinal hemorrhage, pancreatitis
Rare (less than 0.1%): Glossitis
Very rare (less than 0.01%): Ileus[Ref]

Respiratory

Common (1% to 10%): Cough, pharyngitis, dyspnea, rhinitis
Uncommon (0.1% to 1%): Eosinophilic pneumonitis, sinusitis, upper respiratory tract infection, bronchitis
Frequency not reported: Bronchospasm[Ref]

Musculoskeletal

Uncommon (0.1% to 1%): Myalgia, back pain, arthralgia

Genitourinary

Uncommon (0.1% to 1%): Impotence[Ref]

Psychiatric

Uncommon (0.1% to 1%): Depression, insomnia, confusion[Ref]

Other

Common (1% to 10%): Fatigue, asthenia
Uncommon (0.1% to 1%): Fever, malaise, generalized/peripheral edema[Ref]

Immunologic

Uncommon (0.1% to 1%): Viral infection[Ref]

Dermatologic

Uncommon (0.1% to 1%): Rash, alopecia, increased sweating, pemphigus, pruritus, exfoliative dermatitis, photosensitivity reaction, dermatopolymyositis
Rare (less than 0.1%): Urticaria, erythema multiforme, pemphigus
Very rare (less than 0.01%): Psoriasis-like efflorescence
Frequency not reported: Stevens Johnson syndrome, epidermal necrolysis[Ref]

Ocular

Uncommon (0.1% to 1): Amblyopia
Very rare (less than 0.01%): Blurred vision[Ref]

References

1. "Product Information. Accupril (quinapril)." Parke-Davis, Morris Plains, NJ.

2. Cerner Multum, Inc. "Australian Product Information." O 0

3. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Some side effects of quinapril may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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