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Plendil Side Effects

Generic name: felodipine

Medically reviewed by Last updated on Apr 22, 2024.

Note: This document contains side effect information about felodipine. Some dosage forms listed on this page may not apply to the brand name Plendil.

Applies to felodipine: oral tablet extended release.

Serious side effects of Plendil

Along with its needed effects, felodipine (the active ingredient contained in Plendil) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking felodipine:

More common

Less common

Incidence not known

Get emergency help immediately if any of the following symptoms of overdose occur while taking felodipine:

Symptoms of overdose

Other side effects of Plendil

Some side effects of felodipine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common


Incidence not known

For Healthcare Professionals

Applies to felodipine: oral tablet extended release.


The most common adverse events were peripheral edema and headache.[Ref]


Very common (10% or more): Peripheral edema (up to 17.4%)

Common (1% to 10%): Asthenia, warm sensation

Frequency not reported: Chest pain, facial edema, flu-like illness, influenza[Ref]

Peripheral edema was generally mild, but it was age and dose related. It resulted in treatment discontinuation in about 3% of patients.[Ref]

Nervous system

Very common (10% or more): Headache (up to 14.7%)

Common (1% to 10%): Dizziness, paresthesia

Frequency not reported: Syncope, somnolence[Ref]


Common (1% to 10%): Nausea, dyspepsia, constipation

Frequency not reported: Abdominal pain, diarrhea, vomiting, dry mouth, flatulence, acid regurgitation, gingival hyperplasia[Ref]


Common (1% to 10%): Cough, rhinorrhea, sneezing

Frequency not reported: Dyspnea, pharyngitis, bronchitis, sinusitis, epistaxis, respiratory infection[Ref]


Common (1% to 10%): Palpitation, flushing

Frequency not reported: Myocardial infarction, hypotension, angina pectoris, arrhythmia, tachycardia, premature beats[Ref]


Common (1% to 10%): Rash

Frequency not reported: Angioedema, contusion, erythema, urticaria, leukocytoclastic vasculitis[Ref]


Frequency not reported: Arthralgia, back pain, leg pain, foot pain, muscle cramps, myalgia, arm pain, knee pain, hip pain[Ref]


Frequency not reported: Insomnia, depression, anxiety disorders, irritability, nervousness, libido decreased[Ref]


Frequency not reported: Impotence, urinary frequency, urinary urgency, dysuria, polyuria[Ref]


Frequency not reported: Gynecomastia[Ref]


Frequency not reported: Anemia[Ref]


Frequency not reported: ALT increased[Ref]


Frequency not reported: Visual disturbances[Ref]


1. (2002) "Product Information. Plendil (felodipine)." Merck & Co., Inc

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.