Plendil Side Effects
Generic name: felodipine
Medically reviewed by Drugs.com. Last updated on Jan 10, 2025.
Note: This document provides detailed information about Plendil Side Effects associated with felodipine. Some dosage forms listed on this page may not apply specifically to the brand name Plendil.
Applies to felodipine: oral tablet extended release.
Precautions
It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly and to check for unwanted effects.
Low blood pressure (hypotension) may occur while taking this medicine. Check with your doctor right away if you have the following symptoms: blurred vision; confusion; severe dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly; sweating; or unusual tiredness or weakness.
This medicine may cause fluid retention (edema) in some patients. Tell your doctor right away if you have bloating or swelling of the face, arms, hands, lower legs, or feet; tingling of the hands or feet; or unusual weight gain or weight loss.
Redness, swelling, or bleeding of the gums may occur while taking this medicine. Brushing and flossing your teeth carefully and regularly, and massaging your gums may help prevent this. Check with your doctor or dentist if you have any questions about how to take care of your teeth and gums, or if you notice any redness, swelling, or bleeding of your gums.
Serious side effects of Plendil
Along with its needed effects, felodipine (the active ingredient contained in Plendil) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking felodipine:
More common side effects
- bloating or swelling of face, arms, hands, lower legs, or feet
- rapid weight gain
- tingling of hands or feet
- unusual weight gain or loss
Less common side effects
- body aches or pain
- chills
- cough
- difficulty in breathing
- ear congestion
- fever
- headache
- loss of voice
- nasal congestion
- runny nose
- sneezing
- sore throat
- unusual tiredness or weakness
Incidence not known
- blurred vision
- chest pain, tightness, or heaviness
- confusion
- congestion
- cough producing mucus
- diarrhea
- dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
- fast, slow, or irregular heartbeat
- general feeling of discomfort or illness
- hoarseness
- joint pain
- large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
- loss of appetite
- muscle aches and pains
- nausea
- pain or discomfort in arms, jaw, back, or neck
- pale skin
- shivering
- shortness of breath
- sweating
- swelling or puffiness of face
- tender or swollen glands in neck
- trouble in swallowing
- trouble sleeping
- troubled breathing with exertion
- unusual bleeding or bruising
- voice changes
- wheezing
Get emergency help immediately if any of the following symptoms of overdose occur while taking felodipine:
Symptoms of overdose
- feeling of warmth
- redness of the face, neck, arms and occasionally, upper chest
Other side effects of Plendil
Some side effects of felodipine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Less common side effects
- acid or sour stomach
- belching
- burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
- constipation
- heartburn
- indigestion
- lack or loss of strength
- skin rash
- stomach discomfort, upset, or pain
Rare side effects
- bleeding gums
- irritation in mouth
- redness and swelling of gums
Incidence not known
- bloated or full feeling
- bloody nose
- burning while urinating
- decreased interest in sexual intercourse
- difficult or painful urination
- difficulty in moving
- discouragement
- disturbed color perception
- double vision
- dry mouth
- excess air or gas in stomach or intestines
- feeling sad or empty
- fear or nervousness
- frequent strong or increased urge to urinate
- halos around lights
- hives or welts
- inability to have or keep an erection
- increased need to urinate
- increased volume of pale or dilute urine
- irritability
- itching
- loss in sexual ability, desire, drive, or performance
- loss of interest or pleasure
- muscle cramps or stiffness
- night blindness
- overbright appearance of lights
- pain or tenderness around eyes and cheekbones
- passing gas
- passing urine more often
- redness of skin
- sleepiness or unusual drowsiness
- sleeplessness
- sores, welting, or blisters
- swelling of the breasts or breast soreness in both females and males
- swollen joints
- tiredness
- trouble concentrating
- tunnel vision
- unable to sleep
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For healthcare professionals
Applies to felodipine: oral tablet extended release.
General adverse events
The most common adverse events were peripheral edema and headache.[Ref]
Other
- Very common (10% or more): Peripheral edema (up to 17.4%)
- Common (1% to 10%): Asthenia, warm sensation
- Frequency not reported: Chest pain, facial edema, flu-like illness, influenza[Ref]
Peripheral edema was generally mild, but it was age and dose related. It resulted in treatment discontinuation in about 3% of patients.[Ref]
Nervous system
- Very common (10% or more): Headache (up to 14.7%)
- Common (1% to 10%): Dizziness, paresthesia
- Frequency not reported: Syncope, somnolence[Ref]
Gastrointestinal
- Common (1% to 10%): Nausea, dyspepsia, constipation
- Frequency not reported: Abdominal pain, diarrhea, vomiting, dry mouth, flatulence, acid regurgitation, gingival hyperplasia[Ref]
Respiratory
- Common (1% to 10%): Cough, rhinorrhea, sneezing
- Frequency not reported: Dyspnea, pharyngitis, bronchitis, sinusitis, epistaxis, respiratory infection[Ref]
Cardiovascular
- Common (1% to 10%): Palpitation, flushing
- Frequency not reported: Myocardial infarction, hypotension, angina pectoris, arrhythmia, tachycardia, premature beats[Ref]
Dermatologic
- Common (1% to 10%): Rash
- Frequency not reported: Angioedema, contusion, erythema, urticaria, leukocytoclastic vasculitis[Ref]
Musculoskeletal
- Frequency not reported: Arthralgia, back pain, leg pain, foot pain, muscle cramps, myalgia, arm pain, knee pain, hip pain[Ref]
Psychiatric
- Frequency not reported: Insomnia, depression, anxiety disorders, irritability, nervousness, libido decreased[Ref]
Genitourinary
Endocrine
- Frequency not reported: Gynecomastia[Ref]
Hematologic
- Frequency not reported: Anemia[Ref]
Hepatic
- Frequency not reported: ALT increased[Ref]
Ocular
- Frequency not reported: Visual disturbances[Ref]
References
1. (2002) "Product Information. Plendil (felodipine)." Merck & Co., Inc
More about Plendil (felodipine)
- Check interactions
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- Drug images
- Dosage information
- During pregnancy
- Drug class: calcium channel blockers
- Breastfeeding
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Further information
Plendil side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.
