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Pepcid Side Effects

Generic name: famotidine

Medically reviewed by Drugs.com. Last updated on Jul 24, 2023.

Note: This document contains side effect information about famotidine. Some dosage forms listed on this page may not apply to the brand name Pepcid.

Applies to famotidine: oral powder for suspension, oral tablet.

Serious side effects of Pepcid

Along with its needed effects, famotidine (the active ingredient contained in Pepcid) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking famotidine:

Rare

Incidence not known

Other side effects of Pepcid

Some side effects of famotidine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

Rare

For Healthcare Professionals

Applies to famotidine: compounding powder, intravenous solution, oral powder for reconstitution, oral tablet, oral tablet chewable, oral tablet disintegrating.

General

The most commonly reported side effects include headache, dizziness, constipation, and diarrhea.[Ref]

Gastrointestinal

Common (1% to 10%): Constipation, diarrhea

Uncommon (0.1% to 1%): Nausea, vomiting, flatulence, dry mouth, abdominal discomfort or distension[Ref]

Nervous system

Convulsions occurred in patients with renal dysfunction.[Ref]

Common (1% to 10%): Headache, dizziness

Very rare (less than 0.01%): Paresthesia, somnolence, epileptic seizures, convulsion

Frequency not reported: Grand mal seizure, taste disorder[Ref]

Dermatologic

Uncommon (0.1% to 1%): Rash, pruritus

Rare (0.01% to 0.1%): Urticaria, angioneurotic edema

Very rare (less than 0.01%): Alopecia, severe skin reactions, toxic epidermal necrolysis, Stevens-Johnson syndrome, epidermal necrolysis

Frequency not reported: Acne, dry skin, flushing[Ref]

Other

Uncommon (0.1% to 1%): Fatigue

Frequency not reported: Asthenia, fatigue, facial/orbital edema, tinnitus[Ref]

Metabolic

Uncommon (0.1% to 1%): Loss of appetite

Frequency not reported: Anorexia[Ref]

Hematologic

Rare (0.01% to 0.1%): Thrombocytopenia, leukopenia, agranulocytosis, pancytopenia

Frequency not reported: Neutropenia[Ref]

Hepatic

Rare (0.01% to 0.1%): Intrahepatic cholestasis, jaundice, increased liver enzyme abnormalities (transaminases, gamma GT, alkaline phosphatase, bilirubin)

Frequency not reported: Cholestatic jaundice, hepatitis[Ref]

Hypersensitivity

Rare (0.01% to 0.1%): Hypersensitivity reactions, anaphylaxis[Ref]

Respiratory

Rare (0.01% to 0.1%): Bronchospasm

Frequency not reported: Interstitial pneumonia[Ref]

Musculoskeletal

Rare (0.01% to 0.1%): Arthralgia

Very rare (less than 0.01%): Muscle cramps

Frequency not reported: Rhabdomyolysis, musculoskeletal pain[Ref]

Psychiatric

When patients obtained follow-up, psychic disturbances were found to be reversible.[Ref]

Very rare (less than 0.01%): Hallucinations, disorientation, confusion, anxiety, agitation, depression, reduced libido, insomnia

Frequency not reported: Psychic disturbances[Ref]

Cardiovascular

QT interval prolongation occurred in patients with renal dysfunction.[Ref]

Very rare (less than 0.01%): Chest tightness, prolonged QT interval

Frequency not reported: Arrhythmia, atrioventricular block, palpitation[Ref]

Genitourinary

Very rare (less than 0.01%): Impotence[Ref]

Ocular

Frequency not reported: Conjunctival injection[Ref]

Endocrine

Frequency not reported: Gynecomastia[Ref]

Frequently asked questions

References

1. Product Information. Pepcid (famotidine). Merck & Co., Inc. 2002.

2. Product Information. Pepcid AC (famotidine). Johnson and Johnson/Merck. 2001.

3. Cerner Multum, Inc. UK Summary of Product Characteristics.

4. Cerner Multum, Inc. Australian Product Information.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.