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Olsalazine Side Effects

For the Consumer

Applies to olsalazine: oral capsule

Along with its needed effects, olsalazine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur while taking olsalazine:


Some side effects of olsalazine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More Common

  • Abdominal or stomach pain or upset
  • diarrhea
  • loss of appetite

Less Common

For Healthcare Professionals

Applies to olsalazine: oral capsule


The most common adverse events were diarrhea and abdominal pain or cramps.


Very common (10% or more): Diarrhea (11.1%), abdominal pain/cramps (10.1%)

Common (1% to 10%): Nausea, dyspepsia, bloating, vomiting, stomatitis

Uncommon (0.1% to 1%): Rectal bleeding, heartburn

Postmarketing reports: Abdominal pain upper, diarrhea with dehydration, dry mouth, epigastric discomfort, flare in symptoms, flatulence, increased blood in stool, pancreatitis, rectal bleeding, rectal discomfort[Ref]

Nervous system

Common (1% to 10%): Headache, vertigo/dizziness

Uncommon (0.1% to 1%): Lightheadedness

Postmarketing reports: Insomnia, paresthesia, peripheral neuropathy[Ref]


Postmarketing reports: Chest pains, heart block second degree, myocarditis, palpitations, pericarditis, hot flashes, hypertension, orthostatic hypotension


Common (1% to 10%): Arthralgia/joint pain

Postmarketing reports: Chills, muscle cramps, myalgia[Ref]


Common (1% to 10%): Rash, itching

Postmarketing reports: Erythema nodosum, alopecia, erythema, photosensitivity reaction, angioneurotic edema[Ref]


Common (1% to 10%): Fatigue/drowsiness/lethargy

Postmarketing reports: Peripheral edema, tinnitus, fever, tremors


Postmarketing reports: Interstitial pulmonary disease, bronchospasm, dyspnea


Postmarketing reports: Granulomatous hepatitis, nonspecific reactive hepatitis, mild cholestatic hepatitis, ALT or AST elevated beyond the normal range, hepatic enzyme increased, hepatitis, increased bilirubin


Postmarketing reports: Anemia, eosinophilia, hemolytic anemia, leukopenia, lymphopenia, neutropenia, reticulocytosis, thrombocytopenia, aplastic anemia, pancytopenia[Ref]


Postmarketing reports: Interstitial nephritis, nephrotic syndrome


Common (1% to 10%): Upper respiratory infection


Postmarketing reports: Dysuria, hematuria, proteinuria, urinary frequency


Common (1% to 10%): Depression

Uncommon (0.1% to 1%): Insomnia

Postmarketing reports: Irritability, mood swings


Common (1% to 10%): Anorexia


Postmarketing reports: Dry eyes, vision blurred, watery eyes


1. "Product Information. Dipentum (olsalazine)." Meda Pharmaceuticals, Somerset, NJ.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.