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Olsalazine Dosage

Medically reviewed by Last updated on Apr 15, 2021.

Applies to the following strengths: 250 mg

Usual Adult Dose for Ulcerative Colitis - Maintenance

500 mg orally 2 times a day

Use: Maintenance of remission of ulcerative colitis in patients who are intolerant of sulfasalazine

Renal Dose Adjustments

Frequent monitoring recommended.

Liver Dose Adjustments

Frequent monitoring recommended.


-Hypersensitivity to the active component, other salicylates, or any of the ingredients

Safety and efficacy have not been established in pediatric patients.

Consult WARNINGS section for additional precautions.


Data not available

Other Comments

Administration advice:
-Take with food or after meals.
-This drug should be administered in evenly divided doses.

Storage requirements:
-Store in a tightly closed container; protect from moisture.

-HEMATOLOGIC: Signs/symptoms of hematoxicity (e.g., anemia, bruising, fever, mouth ulcers, purpura, sore mouth, unexplained bleeding)
-HYPERSENSITIVITY: Worsening signs/symptoms in patients with severe allergies/asthma
-RENAL: Urinalysis, blood urea nitrogen (BUN), and serum creatinine should be measured every 3 months for the first year, then every 6 months for the next 4 years, and finally once a year for 5 years

Patient advice:
-Inform patients that this drug may cause dizziness or blurred vision, and they should avoid driving or operating machinery if these side effects occur.
-Advise patients to speak to their healthcare provider if they become pregnant, intend to become pregnant, or are breastfeeding.
-Patients should be instructed to contact their healthcare provider if hematoxicity or diarrhea occurs during treatment.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.