Inspra Side Effects
Generic name: eplerenone
Medically reviewed by Drugs.com. Last updated on Mar 11, 2025.
Note: This document provides detailed information about Inspra.
Applies to eplerenone: oral tablet Side Effects associated with eplerenone. Some dosage forms listed on this page may not apply specifically to the brand name Inspra.
Applies to eplerenone: oral tablet.
Precautions
It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly and to decide if you should continue to take it. Blood tests may be needed to check for unwanted effects.
Do not take the following medicines if you are using eplerenone (the active ingredient contained in Inspra)
- Amiloride (e.g., Midamor®) or
- Clarithromycin (e.g., Biaxin®) or
- Itraconazole (e.g., Sporanox®) or
- Ketoconazole (e.g., Nizoral®) or
- Nefazodone (e.g., Serzone®) or
- Nelfinavir (e.g., Viracept®) or
- Ritonavir (e.g., Norvir®) or
- Spironolactone (e.g., Aldactone®) or
- Triamterene (e.g., Dyrenium®) or
- Troleandomycin (e.g., Tao®).
Do not take other medicines unless they have been discussed with your doctor. This especially includes potassium supplements or salt substitutes containing potassium.
This medicine may increase the amount of potassium in your blood. Check with your doctor right away if you are having abdominal or stomach pain; confusion; difficulty with breathing; irregular heartbeats; nausea or vomiting; nervousness; numbness or tingling in the hands, feet, or lips; shortness of breath; or weakness or heaviness of the legs.
Serious side effects of Inspra
Along with its needed effects, eplerenone may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking eplerenone:
Less common side effects
- excess of cholesterol in the blood
- excess of triglycerides in the blood
Incidence not known
- abdominal or stomach pain
- arm, back, or jaw pain
- chest pain or discomfort
- chest tightness or heaviness
- confusion
- difficulty with breathing
- dizziness
- fast or irregular heartbeat
- headache
- irregular heartbeat
- large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
- nausea
- nervousness
- numbness or tingling in the hands, feet, or lips
- pain or discomfort in the arms, jaw, back, or neck
- rash
- shortness of breath
- sweating
- vomiting
- weakness or heaviness of the legs
Other side effects of Inspra
Some side effects of eplerenone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Less common side effects
- abnormal vaginal bleeding
- breast pain
- chills
- cloudy urine
- cough
- diarrhea
- fever
- general feeling of discomfort or illness
- joint pain
- loss of appetite
- muscle aches and pains
- swelling of the breasts or breast soreness in both females and males
- unusual tiredness or weakness
For healthcare professionals
Applies to eplerenone: oral tablet.
General adverse events
Adverse reactions that occurred more frequently in patients treated with this drug compared to placebo were hyperkalemia and increased creatinine.[Ref]
Metabolic
- Very common (10% or more): Potassium greater than 5.5 mEq/L (up to 15.6%)
- Common (1% to 10%): Potassium less than 3.5 mEq/L, potassium 6 mEq/L or greater[Ref]
Renal
- Common (1% to 10%): Creatinine increased
- Frequency not reported: Renal function abnormal[Ref]
Cardiovascular
- Frequency not reported: Myocardial infarction, angina pectoris[Ref]
Nervous system
- Frequency not reported: Headache, dizziness[Ref]
Endocrine
- Frequency not reported: Gynecomastia[Ref]
Hepatic
- Frequency not reported: Gamma-glutamyltransferase increased[Ref]
Dermatologic
- Postmarketing reports: Angioneurotic edema, rash[Ref]
Genitourinary
- Frequency not reported: Abnormal vaginal bleeding[Ref]
See also:
Farxiga
Farxiga (dapagliflozin) is an oral prescription medication that may be given to certain adults with ...
Lasix
Lasix is a loop diuretic used to treat fluid retention from heart, liver, or kidney conditions, and ...
Botox
Botox is used for cosmetic purposes and to treat overactive bladder symptoms, urinary incontinence ...
Valsartan
Valsartan is an angiotensin II receptor blocker (ARB) that may be used to treat high blood pressure ...
Triamcinolone
Triamcinolone is used to treat allergies, skin conditions, ulcerative colitis, and arthritis. Learn ...
Warfarin
Warfarin is an anticoagulant used to prevent heart attacks, strokes, and blood clots. Learn about ...
Diltiazem
Diltiazem is used to treat high blood pressure, angina and certain heart rhythm disorders. Included ...
Atenolol
Atenolol is used to treat angina (chest pain) and hypertension (high blood pressure). Learn about ...
Hydrochlorothiazide
HCTZ (hydrochlorothiazide) used to treat high blood pressure (hypertension) and edema. Includes ...
References
1. (2002) "Product Information. Inspra (eplerenone)." Searle
More about Inspra (eplerenone)
- Check interactions
- Compare alternatives
- Pricing & coupons
- Reviews (2)
- Drug images
- Dosage information
- During pregnancy
- Generic availability
- Drug class: aldosterone receptor antagonists
- Breastfeeding
- En español
Patient resources
Professional resources
Related treatment guides
Further information
Inspra side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.