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Inspra Side Effects

Generic Name: eplerenone

Note: This document contains side effect information about eplerenone. Some of the dosage forms listed on this page may not apply to the brand name Inspra.

In Summary

Common side effects of Inspra include: cough, diarrhea, fatigue, and flu-like symptoms. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to eplerenone: oral tablet

Along with its needed effects, eplerenone (the active ingredient contained in Inspra) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking eplerenone:

Less Common

  • Excess of cholesterol in the blood
  • excess of triglycerides in the blood

Incidence Not Known

  • Abdominal or stomach pain
  • arm, back, or jaw pain
  • chest pain or discomfort
  • chest tightness or heaviness
  • confusion
  • difficulty with breathing
  • dizziness
  • fast or irregular heartbeat
  • headache
  • irregular heartbeat
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • nausea
  • nervousness
  • numbness or tingling in the hands, feet, or lips
  • pain or discomfort in the arms, jaw, back, or neck
  • rash
  • shortness of breath
  • sweating
  • vomiting
  • weakness or heaviness of the legs

Some side effects of eplerenone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less Common

  • Abnormal vaginal bleeding
  • breast pain
  • chills
  • cloudy urine
  • cough
  • diarrhea
  • fever
  • general feeling of discomfort or illness
  • joint pain
  • loss of appetite
  • muscle aches and pains
  • swelling of the breasts or breast soreness in both females and males
  • unusual tiredness or weakness

For Healthcare Professionals

Applies to eplerenone: oral tablet


Metabolic side effects have included hyperkalemia (>5.5 mEq/L). Hyperkalemia was observed in 2.6% of patients with creatinine clearance greater than 100 mL/min, in 5.6% of patients with creatinine clearance of 70 to 100 mL/min, and in 10.4% of patients with creatinine clearance less than 70 mL/min. The principal risk of eplerenone (the active ingredient contained in Inspra) is hyperkalemia, which can result in serious, sometimes fatal arrhythmias.

Other metabolic side effects have included hypercholesterolemia and hypertriglyceridemia in 1% of patients.[Ref]

Nervous system

Nervous system side effects have included dizziness (3%) and headache. In a pharmacokinetic study, headache was reported in 14% to 63% of patients.[Ref]


General side effects have included fatigue and influenza-like symptoms.[Ref]


Renal side effects have included albuminuria in 1% of patients.[Ref]


Respiratory side effects have included cough in 2% of patients.[Ref]


Gastrointestinal side effects have included diarrhea in 2% and abdominal pain in 1% of patients.[Ref]


Endocrine side effects have included gynecomastia (up to 1%) and mastodynia (up to 1.3%) of male patients. Abnormal vaginal bleeding was reported in 2.5% of female patients.[Ref]


Hepatic side effects have included increases in serum alanine aminotransferase (ALT) and gamma glutamyl transpeptidase (GGT).[Ref]


1. Zillich AJ, Carter BL "Eplerenone - a novel selective aldosterone blocker." Ann Pharmacother 36 (2002): 1567-76

2. "Product Information. Inspra (eplerenone)." Searle, Chicago, IL.

3. Ravis WR, Reid S, Sica DA, Tolbert DS "Pharmacokinetics of eplerenone after single and multiple dosing in subjects with and without renal impairment." J Clin Pharmacol 45 (2005): 810-21

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.