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Generic name: eplerenoneep-LER-e-none ]
Drug classes: Aldosterone receptor antagonists, Potassium-sparing diuretics

Medically reviewed by on Mar 8, 2024. Written by Cerner Multum.

What is Inspra?

Inspra is used to lower the risk of death from heart failure after a heart attack.

Inspra is also used to treat high blood pressure (hypertension).

Inspra may also be used for purposes not listed in this medication guide.

This drug side effects

Get emergency medical help if you have signs of an allergic reaction: hives; severe stomach pain; difficulty breathing; swelling of your face, lips, tongue, or throat.

Inspra may cause serious side effects. Call your doctor at once if you have:

Common side effects of Inspra may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


You may not be able to take Inspra if you have severe kidney disease, high potassium levels in your blood, or type 2 diabetes with increased levels of albumin (a protein) in your urine.

Tell your doctor about all your current medicines and any you start or stop using. Many drugs can interact, and some drugs should not be used together.

Before taking this medicine

You may not be able to take this medicine if you are allergic to Inspra, or if you have:

Some medicines can cause unwanted or dangerous effects when used with Inspra. Your doctor may change your treatment plan if you also use:

Tell your doctor if you have ever had:

Tell your doctor if you are pregnant or breastfeeding.

It is not known whether Inspra will harm an unborn baby. However, having high blood pressure during pregnancy may cause complications such as diabetes or eclampsia (dangerously high blood pressure that can lead to medical problems in both mother and baby). Heart failure can get worse during pregnancy and may cause complications such as premature birth. The benefit of treating hypertension or heart failure may outweigh any risks to the baby.

This medicine may affect fertility (ability to have children) in men.

How should I take Inspra?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Inspra may be taken with or without food.

You may need blood tests, and your blood pressure will need to be checked often.

If you have high blood pressure, keep using Inspra even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medicine for the rest of your life.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking Inspra?

Do not use potassium supplements or salt substitutes, unless your doctor has told you to.

What other drugs will affect Inspra?

Tell your doctor about all your current medicines. Many drugs can affect Inspra, especially:

This list is not complete and many other drugs may affect Inspra. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.