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Eplerenone

Generic Name: eplerenone (ep LER e none)
Brand Name: Inspra

Medically reviewed on Jul 12, 2018

What is eplerenone?

Eplerenone blocks the actions of the hormone aldosterone in the body. Aldosterone is important for the regulation of blood pressure.

Eplerenone is used to treat congestive heart failure after a heart attack. Eplerenone is also used to treat high blood pressure (hypertension).

Eplerenone may also be used for purposes not listed in this medication guide.

Important Information

You may not be able to take eplerenone if you have severe kidney disease, high potassium levels in your blood, or type 2 diabetes with increased levels of albumin (a protein) in your urine.

Serious drug interactions can occur when certain medicines are used together with eplerenone. Tell each of your healthcare providers about all medicines you use now, and any medicine you start or stop using.

Before taking this medicine

You may not be able to take this medicine if you are allergic to eplerenone, or if you have:

  • high potassium levels in your blood (hyperkalemia);

  • severe kidney disease; or

  • type 2 diabetes with increased levels of albumin (a protein) in your urine.

Some medicines can interact with eplerenone and should not be used at the same time. Your doctor may need to change your treatment plan if you use any of the following drugs:

To make sure eplerenone is safe for you, tell your doctor if you have:

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It is not known whether eplerenone passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.

How should I take eplerenone?

Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take eplerenone in larger or smaller amounts or for longer than recommended.

Eplerenone may be taken with or without food.

While using eplerenone, you may need blood tests, and your blood pressure will need to be checked often.

If you are being treated for high blood pressure, keep using this medicine even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking eplerenone?

Do not use potassium supplements or salt substitutes while you are taking eplerenone, unless your doctor has told you to.

This drug side effects

Get emergency medical help if you have signs of an allergic reaction: hives; severe stomach pain; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • a light-headed feeling, like you might pass out;

  • diarrhea, vomiting;

  • little or no urination;

  • fast or uneven heartbeats;

  • trouble breathing;

  • swelling in your feet or lower legs;

  • high potassium--nausea, slow or unusual heart rate, weakness, loss of movement; or

  • low potassium--leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling.

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Eplerenone dosing information

Usual Adult Dose for Congestive Heart Failure:

Initial dose: 25 mg orally once a day; titrate to the target dose preferably within 4 weeks as tolerated.
Target dose: 50 mg orally once a day

Use: To improve survival of stable patients with symptomatic heart failure with reduced ejection fraction (40% or less) after an acute myocardial infarction.

Usual Adult Dose for Hypertension:

Initial dose: 50 mg orally once a day
Maintenance dose: 50 mg orally once or twice a day
Maximum dose: 100 mg/day

Comments:
-Full therapeutic effect is apparent within 4 weeks.
-Patients with inadequate blood pressure response to the initial dose may be increased to 50 mg twice a day.

What other drugs will affect eplerenone?

Many drugs can interact with eplerenone, and some drugs should not be used together. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any you start or stop using, especially:

This list is not complete and many other drugs can interact with eplerenone. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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