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Eplerenone Side Effects

Medically reviewed by Last updated on Nov 2, 2023.

Applies to eplerenone: oral tablet.

Serious side effects of Eplerenone

Along with its needed effects, eplerenone may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking eplerenone:

Less common

  • Excess of cholesterol in the blood
  • excess of triglycerides in the blood

Incidence not known

  • Abdominal or stomach pain
  • arm, back, or jaw pain
  • chest pain or discomfort
  • chest tightness or heaviness
  • confusion
  • difficulty with breathing
  • dizziness
  • fast or irregular heartbeat
  • headache
  • irregular heartbeat
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • nausea
  • nervousness
  • numbness or tingling in the hands, feet, or lips
  • pain or discomfort in the arms, jaw, back, or neck
  • rash
  • shortness of breath
  • sweating
  • vomiting
  • weakness or heaviness of the legs

Other side effects of Eplerenone

Some side effects of eplerenone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Abnormal vaginal bleeding
  • breast pain
  • chills
  • cloudy urine
  • cough
  • diarrhea
  • fever
  • general feeling of discomfort or illness
  • joint pain
  • loss of appetite
  • muscle aches and pains
  • swelling of the breasts or breast soreness in both females and males
  • unusual tiredness or weakness

For Healthcare Professionals

Applies to eplerenone: oral tablet.


Adverse reactions that occurred more frequently in patients treated with this drug compared to placebo were hyperkalemia and increased creatinine.[Ref]


Very common (10% or more): Potassium greater than 5.5 mEq/L (up to 15.6%)

Common (1% to 10%): Potassium less than 3.5 mEq/L, potassium 6 mEq/L or greater[Ref]


Common (1% to 10%): Creatinine increased

Frequency not reported: Renal function abnormal[Ref]


Frequency not reported: Myocardial infarction, angina pectoris[Ref]

Nervous system

Frequency not reported: Headache, dizziness[Ref]


Frequency not reported: Gynecomastia[Ref]


Frequency not reported: Gamma-glutamyltransferase increased[Ref]


Postmarketing reports: Angioneurotic edema, rash[Ref]


Frequency not reported: Abnormal vaginal bleeding[Ref]


1. Product Information. Inspra (eplerenone). Searle. 2002.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.