GlipiZIDE XL Side Effects
Generic name: glipizide
Medically reviewed by Drugs.com. Last updated on Jun 21, 2021.
Note: This document contains side effect information about glipizide. Some dosage forms listed on this page may not apply to the brand name GlipiZIDE XL.
Applies to glipizide: oral tablets.
Side effects include:
Glipizide (the active ingredient contained in GlipiZIDE XL) metformin hydrochloride fixed combination: Upper respiratory tract infection, diarrhea, dizziness, hypertension, nausea/vomiting, musculoskeletal pain, headache, abdominal pain, urinary tract infection.
For Healthcare Professionals
Applies to glipizide: compounding powder, oral tablet, oral tablet extended release.
The more commonly reported side effects have included dizziness, diarrhea, nervousness, tremor, hypoglycemia, and flatulence.[Ref]
Common (1% to 10%): Hypoglycemia
Uncommon (less than 1%): Thirst
Common (1% to 10%): Syncope
Frequency not reported: Impaired hepatic function, hepatitis, jaundice, mild to moderate ALT, LDH, alkaline phosphatase elevations
Postmarketing reports: Cholestatic and hepatocellular forms of liver injury accompanied by jaundice[Ref]
Dermatologic side effects frequently disappear with continued therapy. Photosensitivity has been reported with other sulfonylureas.[Ref]
Common (1% to 10%): Sweating, pruritus
Uncommon (less than 1%): Rash, urticaria
Common (1% to 10%): Nausea, diarrhea, constipation, gastralgia, vomiting, flatulence, dyspepsia
Uncommon (less than 1%): Anorexia, trace blood in stool
Frequency not reported: Gastrointestinal irritation, gastrointestinal bleeding
Postmarketing reports: Abdominal pain[Ref]
Gastrointestinal side effects appear to be dose-related and may disappear on division or reduction of dosage.[Ref]
Common (1% to 10%): Polyuria
Common (1% to 10%): Arthralgia, leg cramps, myalgia[Ref]
Common (1% to 10%): Headache, dizziness, nervousness, tremors, paresthesia, hypesthesia
Uncommon (less than 1%): Migraine
Frequency not reported: Drowsiness[Ref]
Common (1% to 10%): Blurred vision
Frequency not reported: Diplopia, abnormal vision, visual impairment, decreased vision[Ref]
Common (1% to 10%): Asthenia, pain
Uncommon (less than 1%): Chills, edema
Frequency not reported: Confusion[Ref]
Common (1% to 10%): Rhinitis
Frequency not reported: Mild to moderate BUN and creatinine elevations
More about GlipiZIDE XL (glipizide)
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- During pregnancy
- Drug class: sulfonylureas
Related treatment guides
1. "Product Information. Glucotrol (glipizide)." Pfizer U.S. Pharmaceuticals (2002):
2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
3. Cerner Multum, Inc. "Australian Product Information." O 0
4. Feinglos MN, Lebovitz HE "Long-term safety and efficacy of glipizide." Am J Med 75 (1983): 60-6
5. Moder KG, Schwenk NM "A coproporphyria-like syndrome induced by glipizide." Mayo Clin Proc 66 (1991): 312-6
6. Asplund K, Wiholm BE, Lundman B "Severe hypoglycaemia during treatment with glipizide." Diabet Med 8 (1991): 726-31
7. Brogden RN, Heel RC, Pakes GE, Speight TM, Avery GS "Glipizide: a review of its pharmacological properties and therapeutic use." Drugs 18 (1979): 329-53
8. Lebovitz HE "Glipizide: a second-generation sulfonylurea hypoglycemic agent. Pharmacology, pharmacokinetics and clinical use." Pharmacotherapy 5 (1985): 63-77
9. Prendergast BD "Glyburide and glipizide, second-generation oral sulfonylurea hypoglycemic agents." Clin Pharm 3 (1984): 473-85
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.