GlipiZIDE XL Side Effects

Generic Name: glipizide

Note: This page contains information about the side effects of glipizide. Some of the dosage forms included on this document may not apply to the brand name GlipiZIDE XL.

For the Consumer

Applies to glipizide: oral tablet, oral tablet extended release

In addition to its needed effects, some unwanted effects may be caused by glipizide (the active ingredient contained in GlipiZIDE XL). In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking glipizide:

• Anxiety
• blurred vision
• burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
• chills
• cold sweats
• coma
• confusion
• cool, pale skin
• depression
• difficulty with moving
• dizziness
• fainting
• fast heartbeat
• headache
• increased hunger
• joint pain
• leg cramps
• muscle aching or cramping
• muscle pain or stiffness
• nausea
• nervousness
• nightmares
• pain in the joints
• problems in urination or increase in the amount of urine
• seizures
• shakiness
• slurred speech
• sweating
• swollen joints
• unusual tiredness or weakness

• Abdominal or stomach pain
• bloating
• bloody or black, tarry stools
• body aches or pain
• burning, dry, or itching eyes
• clay-colored stools
• congestion
• constipation
• cough
• dark urine
• decreased vision or other changes in vision
• diarrhea
• difficult or labored breathing
• difficult or painful urination
• dryness or soreness of the throat
• excessive tearing
• fainting
• fast, slow, or irregular heartbeat
• feeling of warmth
• fever
• heartburn
• hoarseness
• indigestion
• itching
• loss of appetite
• pain in the eye
• pounding in the ears
• rash
• redness of the face, neck, arms and occasionally, upper chest
• redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
• runny nose
• severe stomach pain
• shortness of breath
• tender, swollen glands in the neck
• tightness in the chest
• trouble in swallowing
• unpleasant breath odor
• voice changes
• vomiting of blood or material that looks like coffee grounds
• wheezing
• yellow eyes or skin

• Agitation
• back or leg pains
• bleeding gums
• blood in the urine or stools
• chest pain
• convulsions
• decreased urine output
• fluid-filled skin blisters
• general body swelling
• general feeling of tiredness or weakness
• high fever
• hostility
• increased thirst
• irritability
• lethargy
• light-colored stools
• lower back or side pain
• muscle twitching
• nosebleeds
• pinpoint red pots on the skin
• rapid weight gain
• sensitivity to the sun
• skin thinness
• sores, ulcers, or white spots on the lips or in the mouth
• stupor
• swelling of the face, ankles, or hands
• unusual bleeding or bruising

Minor Side Effects

Some of the side effects that can occur with glipizide may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

• Indigestion
• passing of gas

• Acid or sour stomach
• belching
• excess air or gas in the stomach or intestines
• full feeling
• pain
• sleeplessness
• sneezing
• stuffy nose
• trouble sleeping
• unable to sleep

• Decreased interest in sexual intercourse
• dizziness or lightheadedness
• excessive muscle tone
• feeling of constant movement of self or surroundings
• flushing or redness of the skin
• headache, severe and throbbing
• hives or welts
• inability to have or keep an erection
• loss in sexual ability, desire, drive, or performance
• mood or mental changes
• muscle stiffness
• muscle tension or tightness
• sensation of spinning
• skin rash, encrusted, scaly, and oozing
• sleepiness or unusual drowsiness
• unusually warm skin
• walking in unusual manner
• weight loss

• Increased sensitivity of the skin to sunlight
• severe sunburn

For Healthcare Professionals

Applies to glipizide: compounding powder, oral tablet, oral tablet extended release

General

The majority of side effects have been dose related, transient, and have responded to dose reduction or withdrawal of the drug. As with other sulfonylureas, some side effects associated with hypersensitivity may be severe and deaths have been reported in some instances.^[Ref]

Cardiovascular

Common (1% to 10%): Syncope
Uncommon (less than 1%): Arrhythmia, flushing, hypertension^[Ref]

Dermatologic

Common (1% to 10%): Sweating, pruritus
Uncommon (less than 1%): Rash, urticaria
Frequency not reported: Rash, erythema, morbilliform or maculopapular eruptions, urticaria, pruritus, eczema^[Ref]

Dermatologic side effects frequently disappear with continued therapy. Photosensitivity has been reported with other sulfonylureas.^[Ref]

Gastrointestinal

Gastrointestinal side effects appear to be dose-related and may disappear on division or reduction of dosage.^[Ref]

Common (1% to 10%): Nausea, diarrhea, constipation, gastralgia, vomiting, flatulence, dyspepsia
Uncommon (less than 1%): Anorexia, trace blood in stool
Frequency not reported: Gastrointestinal irritation, gastrointestinal bleeding
Postmarketing reports: Abdominal pain^[Ref]

Genitourinary

Common (1% to 10%): Polyuria
Uncommon (less than 1%): Dysuria^[Ref]

Metabolic

Common (1% to 10%): Hypoglycemia
Uncommon (less than 1%): Thirst
Frequency not reported: Disulfiram like reactions, hepatic porphyria, hyponatremia, syndrome of inappropriate antidiuretic hormone (SIADH), elevation of LDH^[Ref]

Musculoskeletal

Common (1% to 10%): Arthralgia, leg cramps, myalgia^[Ref]

Nervous system

Common (1% to 10%): Headache, dizziness, nervousness, tremors, paresthesia, hypesthesia
Uncommon (less than 1%): Migraine
Frequency not reported: Drowsiness^[Ref]

Ocular

Common (1% to 10%): Blurred vision
Uncommon (less than 1%): Pain in the eye, conjunctivitis, retinal hemorrhage
Frequency not reported: Diplopia, abnormal vision, visual impairment, decreased vision^[Ref]

Other

Common (1% to 10%): Asthenia, pain
Uncommon (less than 1%): Chills, edema
Frequency not reported: Vertigo, malaise^[Ref]

Psychiatric

Common (1% to 10%): Insomnia, anxiety, depression
Frequency not reported: Confusion^[Ref]

Respiratory

Common (1% to 10%): Rhinitis
Uncommon (less than 1%): Pharyngitis, dyspnea^[Ref]

Hematologic

Frequency not reported: Leucopenia, agranulocytosis, thrombocytopenia, aplastic anemia, hemolytic anemia, pancytopenia, elevation of alkaline phosphatase, BUN, and creatinine^[Ref]

Hepatic

Frequency not reported: Impaired hepatic function, hepatitis, jaundice, elevation of SGOT
Postmarketing reports: Cholestatic and hepatocellular forms of liver injury accompanied by jaundice^[Ref]

Not all side effects for GlipiZIDE XL may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

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