Skip to main content

Glipizide XL Dosage

Medically reviewed by Last updated on Feb 28, 2022.

Generic name: GLIPIZIDE 2.5mg
Dosage form: tablet, extended release

Recommended Dosing

GLIPIZIDE XL should be administered orally with breakfast or the first main meal of the day.

The recommended starting dose of GLIPIZIDE XL is 5 mg once daily. Start patients at increased risk for hypoglycemia (e.g. the elderly or patients with hepatic insufficiency) at 2.5 mg [see Use in Specific Population (8.5, 8.6)].

Dosage adjustment can be made based on the patient's glycemic control. The maximum recommended dose is 20 mg once daily.

Patients receiving immediate release glipizide may be switched to GLIPIZIDE XL once daily at the nearest equivalent total daily dose.

Use with Other Glucose Lowering Agents

When adding GLIPIZIDE XL to other anti-diabetic drugs, initiate GLIPIZIDE XL at 5 mg once daily. Start patients at increased risk for hypoglycemia at a lower dose.

When colesevelam is coadministered with glipizide ER, maximum plasma concentration and total exposure to glipizide is reduced. Therefore, GLIPIZIDE XL should be administered at least 4 hours prior to colesevelam.

More about GlipiZIDE XL (glipizide)

Patient resources

Other brands
Glucotrol, Glucotrol XL

Professional resources

Related treatment guides

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.