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Desyrel Side Effects

Generic name: trazodone

Medically reviewed by Last updated on Oct 20, 2022.

Note: This document contains side effect information about trazodone. Some dosage forms listed on this page may not apply to the brand name Desyrel.

Applies to trazodone: oral tablet, oral tablet extended release.


Oral route (Tablet, Extended Release; Tablet)

Antidepressants increased the risk compared to placebo of suicidal thinking and behavior in children, adolescents, and young adults with major depressive disorder (MDD) and other psychiatric disorders in short-term studies. Short-term studies did not show an increase in the risk of suicidality with antidepressants compared with placebo in adults beyond age 24, and there was a reduction in risk with antidepressants compared with placebo in adults aged 65 or older. The use of trazodone hydrochloride or any other antidepressant in a child, adolescent, or young adult must balance this risk with the clinical need. Closely monitor patients of all ages for clinical worsening, suicidality, or unusual changes in behavior. Families and caregivers should be advised of the need for close observation and communication with the prescriber. Not approved for pediatric use.

Serious side effects of Desyrel

Along with its needed effects, trazodone (the active ingredient contained in Desyrel) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking trazodone:

More common

Less common


Other side effects of Desyrel

Some side effects of trazodone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common

For Healthcare Professionals

Applies to trazodone: compounding powder, oral tablet, oral tablet extended release.


The most commonly reported side effects included drowsiness, dry mouth, dizziness, and lightheadedness.[Ref]

Nervous system

Drowsiness has occurred during the first few days of treatment, and usually disappeared with continue administration.[Ref]

Very common (10% or more): Drowsiness (up to 41%), dizziness (up to 28%), lightheadedness (up to 28%), headache (up to 20%)

Common (1% to 10%): Decreased concentration, head full-heavy, incoordination, syncope, tremor

Frequency not reported: Akathisia, altered taste, convulsion, decreased alertness, dystonia, expressive aphasia, impaired memory, impaired speech, memory disturbance, motor impairment, neuroleptic malignant syndrome, numbness, paresthesia, serotonin syndrome, vertigo

Postmarketing reports: Aphasia, ataxia, cerebrovascular accident, extrapyramidal symptoms, grand mal seizures, stupor, tardive dyskinesia[Ref]


Very common (10% or more): Dry mouth (up to 34%), nausea (up to 13%), vomiting (up to 13%)

Common (1% to 10%): Abdominal disorder, constipation, diarrhea, gastric disorder

Frequency not reported: Dyspepsia, flatulence, gastroenteritis, hypersalivation, increased salivation, paralytic ileus, stomach pain

Postmarketing reports: Increased amylase[Ref]


Very common (10% or more): Hypertension (up to 20%)

Common (1% to 10%): Edema, hypotension

Frequency not reported: Bradycardia, cardiac arrhythmias, chest pain, ECG abnormalities, increased risk of bleeding, orthostatic hypotension, palpitations, premature ventricular beats, QT prolongation, sinus bradycardia, tachycardia, Torsade de pointes, ventricular couplets, ventricular tachycardia

Postmarketing reports: Atrial fibrillation, cardiac arrest, cardiospasm, conduction block, congestive heart failure, myocardial infarction, vasodilation, ventricular ectopic activity[Ref]

QT prolongation, Torsade de pointes, and ventricular tachycardia have been reported in patients with doses up to 100 mg/day.[Ref]


Very common (10% or more): Blurred vision (up to 15%)

Common (1% to 10%): Itching eyes, red eyes, tired eyes

Frequency not reported: Angle-closure glaucoma, myoclonus

Postmarketing reports: Diplopia[Ref]


Very common (10% or more): Nervousness (up to 15%)

Common (1% to 10%): Confusion

Frequency not reported: Activation of mania/hypomania, aggressive reaction, agitation (sometimes exacerbating to delirium), anxiety, cognitive impairment, confusional state, delusions, discontinuation syndrome, hallucinations, hypomania, increased libido, insomnia, libido decreased, mania, nightmares, restlessness, suicidal behavior, suicidal ideation, suicidal thoughts, withdrawal syndrome

Postmarketing reports: Abnormal dreams, paranoid reaction, psychoses[Ref]


Very common (10% or more): Fatigue (up to 11%)

Common (1% to 10%): Aches, malaise, pain

Frequency not reported: Fever, weakness

Postmarketing reports: Chills, unexplained death[Ref]


Common (1% to 10%): Weight gain, weight loss

Frequency not reported: Anorexia, hyponatremia, increased appetite[Ref]


Common (1% to 10%): Nasal congestion, sinus congestion

Frequency not reported: Dyspnea, shortness of breath

Postmarketing reports: Apnea[Ref]


Common (1% to 10%): Skin condition

Frequency not reported: Hyperhidrosis, pruritus, skin rash

Postmarketing reports: Alopecia, hirsutism, leuconychia, psoriasis, urticaria[Ref]


Frequency not reported: Delayed urine flow, early menses, hematuria, impotence, increased urinary frequency, micturition disorders, missed periods, priapism, retrograde ejaculation

Postmarketing reports: Breast engorgement, breast enlargement, clitorism, lactation, urinary incontinence, urinary retention[Ref]


Frequency not reported: Cholestasis intrahepatic, elevated liver enzymes, fulminant hepatitis, hepatic failure with potentially fatal outcome, hepatic function abnormalities, hepatitis, hepatocellular damage, jaundice, severe hepatic disorders

Postmarketing reports: Cholestasis, hyperbilirubinemia, liver enzyme alterations[Ref]


Frequency not reported: Agranulocytosis, anemia, blood dyscrasias, eosinophilia, leukopenia, thrombocytopenia

Postmarketing reports: Hemolytic anemia, leukocytosis, methemoglobinemia[Ref]


Frequency not reported: Arthralgia, back pain, limb pain, muscle twitches, myalgia[Ref]


Frequency not reported: Allergic reactions[Ref]


Frequency not reported: Influenza-like symptoms[Ref]


Frequency not reported: Syndrome of inappropriate antidiuretic hormone (SIADH) secretion[Ref]

Frequently asked questions


1. (2001) "Product Information. Desyrel (trazodone)." Bristol-Myers Squibb

2. Cerner Multum, Inc. "UK Summary of Product Characteristics."

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.